Fernanda Fernandes Terra

Combinational BET and mTOR inhibition unveils EGR1 as acute myeloid leukemia prognostic biomarker

Marcela Teatin Latância, Wellington Fernandes da Silva, Elayne Bragança-Jardim, Fernanda Fernandes Terra et autres

This study investigated the anti-leukemic potential of BET inhibitors in combination with mTOR inhibitors, focusing on both BET-resistant and BET-sensitive AML cell lines. Our findings reveal a significant suppression of proliferation and induction of apoptosis across all tested cell lines following combined …

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Lack of mTORC2 signaling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis

Aline Ignácio, Marcella Cipelli, Tatiane Takiishi, Cristhiane Fávero de Aguiar et autres

The mammalian target of rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), we investigated the role of mTOR …

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Lack of mTORC2 signaling in CD11c + myeloid cells inhibits their migration and ameliorates experimental colitis

Aline Ignácio, Marcella Cipelli, Tatiane Takiishi, Cristhiane Fávero de Aguiar et autres

Abstract Mammalian target of rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in tissue-resident CD11c + myeloid cells (CD11cRic Δ/Δ ), this study investigated the role of …

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Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury

Cristhiane Fávero de Aguiar, Felipe Corrêa‐da‐Silva, Michelangelo Bauwelz Gonzatti, Monara Kaélle Sérvulo Cruz Angelim et autres

Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized by their reactivity to glycolipids presented by CD1d. iNKT cells are found throughout the body, and little is known about their tissue-specific metabolic regulation. Here, we show that splenic …

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Aplicação da modelagem com o uso das novas tecnologias no ensino médio e a sua interrelação com a vivência em laboratórios de Engenharia de Volta Redonda

Ingrid Russoni e Lima, bonifácio de Oliveira Fialho, Leonardo Martins da silva, Fernanda Fernandes Terra et autres

Anais do Simpósio de Engenharia Metalúrgica e de Materiais Sul Fluminense (978-85-5722-634-0) - Aplicação Da Modelagem Com O Uso Das Novas Tecnologias No Ensino Médio E A Sua Interrelação Com A Vivência Em Laboratórios De Engenharia De Volta Redonda

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Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis

Cristiane Naffah de Souza Breda, Leandro Carvalho Dantas Breda, Larissa Anastácio da Costa Carvalho, Mariane Tami Amano et autres

Abstract Sepsis is a complex infectious syndrome in which neutrophil participation is crucial for patient survival. Neutrophils quickly sense and eliminate the pathogen by using different effector mechanisms controlled by metabolic processes. The mammalian target of rapamycin (mTOR) pathway is an important …

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Host dysbiosis negatively impacts IL-9-producing T-cell differentiation and antitumour immunity

Rafael Ribeiro Almeida, Raquel de Souza Vieira, Ângela Castoldi, Fernanda Fernandes Terra et autres

BACKGROUND: Host-microbiota interactions shape T-cell differentiation and promote tumour immunity. Although IL-9-producing T cells have been described as potent antitumour effectors, their role in microbiota-mediated tumour control remains unclear. METHODS: We analysed the impact of the intestinal microbiota on the differentiation of …

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Interleukin-6 and the Gut Microbiota Influence Melanoma Progression in Obese Mice

Felipe V. Pereira, Amanda Campelo Lima de Melo, Marina Bezerra da Silva, Filipe Menegatti de Melo et autres

mice can stimulate tumor development in lean WT mice. Taken together, our data show that in some conditions IL-6 and the gut microbiota are key mediators that link obesity and melanoma.

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Using Precisely Defined in vivo Microbiotas to Understand Microbial Regulation of IgE

Madeleine Wyss, Kirsty Brown, Carolyn A. Thomson, Mia Koegler et autres

Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum IgE levels. An increase in microbial richness, providing it occurs in a critical developmental window early in …

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Papel da obesidade na rejeição ao transplante de pele experimental

Fernanda Fernandes Terra

calma necessária para seguir em frente.

Fecal IgA Levels and Gut Microbiota Composition Are Regulated by Invariant Natural Killer T Cells

Cristhiane Fávero de Aguiar, Ângela Castoldi, Mariane Tami Amano, Aline Ignácio et autres

BACKGROUND: The gut microbiota is a key element to support host homeostasis and the development of the immune system. The relationship between the microbiota and immunity is a 2-way road, in which the microbiota contributes to the development/function of immune cells and …

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NLRP3 gain-of-function in CD4+ T lymphocytes ameliorates experimental autoimmune encephalomyelitis

Tárcio Teodoro Braga, Wesley Nogueira Brandão, Hatylas F. Z de Azevedo, Fernanda Fernandes Terra et autres

Abstract NLRP3 inflammasome [NLR (nucleotide-binding domain, leucine-rich repeat containing protein) Pyrin-domain-containing 3 ] functions as an innate sensor of several PAMPs and DAMPs (pathogen- and damage-associated molecular patterns). It has been also reported as a transcription factor related to Th2 pattern, although …

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