Aline Ignácio

Lack of mTORC2 signaling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis

Aline Ignácio, Marcella Cipelli, Tatiane Takiishi, Cristhiane Fávero de Aguiar et autres

The mammalian target of rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), we investigated the role of mTOR …

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Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk

Amanda Zaparoli Zucoloto, Jared M. Schlechte, Aline Ignácio, Carolyn A. Thomson et autres

During bloodstream infections, neutrophils home to the liver as part of an intravascular immune response to eradicate blood-borne pathogens, but the mechanisms regulating this crucial response are unknown. Using in vivo imaging of neutrophil trafficking in germ-free and gnotobiotic mice, we demonstrate …

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Lack of mTORC2 signaling in CD11c + myeloid cells inhibits their migration and ameliorates experimental colitis

Aline Ignácio, Marcella Cipelli, Tatiane Takiishi, Cristhiane Fávero de Aguiar et autres

Abstract Mammalian target of rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in tissue-resident CD11c + myeloid cells (CD11cRic Δ/Δ ), this study investigated the role of …

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Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis

Cristiane Naffah de Souza Breda, Leandro Carvalho Dantas Breda, Larissa Anastácio da Costa Carvalho, Mariane Tami Amano et autres

Abstract Sepsis is a complex infectious syndrome in which neutrophil participation is crucial for patient survival. Neutrophils quickly sense and eliminate the pathogen by using different effector mechanisms controlled by metabolic processes. The mammalian target of rapamycin (mTOR) pathway is an important …

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Fecal IgA Levels and Gut Microbiota Composition Are Regulated by Invariant Natural Killer T Cells

Cristhiane Fávero de Aguiar, Ângela Castoldi, Mariane Tami Amano, Aline Ignácio et autres

BACKGROUND: The gut microbiota is a key element to support host homeostasis and the development of the immune system. The relationship between the microbiota and immunity is a 2-way road, in which the microbiota contributes to the development/function of immune cells and …

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Infection: Immunological Barriers

Marcella Cipelli, Aline Ignácio, Niels Olsen Saraiva Câmara

Abstract Microorganisms can infect a host through various portals of entry. The host attempts to counter microbial infection and dissemination using many physical, chemical and immunological strategical barriers. Among them, epithelial cell layer comprises the outer barrier defence of the body being …

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Contributors

Nur Elina Abdul Mutalib, Bianca de Almeida-Pititto, Ana Clara Matoso Montuori de Andrade, José Luiz de Brito Alves et autres

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Mesenchymal stromal cells modulate gut inflammation in experimental colitis

Cristhiane Fávero de Aguiar, Ângela Castoldi, Vinícius Andrade‐Oliveira, Aline Ignácio et autres

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Beneficial effects of Red Light-Emitting Diode treatment in experimental model of acute lung injury induced by sepsis

Silvia Goes Costa, Éric Diego Barioni, Aline Ignácio, Juliana Albuquerque et autres

Sepsis is a severe disease with a high mortality index and it is responsible for the development of acute lung injury (ALI). We evaluated the effects of light-emitting diode (LED) on ALI induced by sepsis. Balb-c mice were injected with lipopolysaccharide or …

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24. Heart health and microorganisms: the unexpected beat

Ângela Castoldi, Aline Ignácio, Tatiana Takiishi, Niels Olsen Saraiva Câmara

The human body is colonized by an extremely complex ecosystem composed of many commensal organisms such as viruses, bacteria and fungi, which together are called microbiota. The microbiota, in particular the gut microbiota, has important metabolic functions which influence the integrity of …

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Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88

Ângela Castoldi, Vinícius Andrade‐Oliveira, Cristhiane Fávero de Aguiar, Mariane Tami Amano et autres

The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose homeostasis, elevated Dectin-1 expression in adipose tissue (AT), …

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Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

Frederico R. C. Costa, Marcela Francozo, Gabriela Gonçalves de Oliveira, Aline Ignácio et autres

Type 1 diabetes (T1D) is an autoimmune disease that is triggered by both genetic and environmental factors, resulting in the destruction of pancreatic β cells. The disruption of the intestinal epithelial barrier and consequent escape of microbial products may be one of …

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