Koji Ohmori

PPARγ activation mitigates glucocorticoid receptor‐induced excessive lipolysis in adipocytes via homeostatic crosstalk

Arif Ul Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori et autres

Proper balance between lipolysis and lipogenesis in adipocytes determines the release of free fatty acids (FFA) and glycerol, which is crucial for whole body lipid homeostasis. Although, dysregulation of lipid homeostasis contributes to various metabolic complications such as insulin resistance, the regulatory …

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GPR120 in adipocytes has differential roles in the production of pro-inflammatory adipocytokines

Arif Ul Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori et autres

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Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes

Arif Ul Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori et autres

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RANKL system in vascular and valve calcification with aging

Ryo Kawakami, Hironori Nakagami, Takahisa Noma, Koji Ohmori et autres

Vascular and cardiac valve calcification is associated with cardiovascular mortality in the general population. Increasing clinical and experimental evidence suggests that inflammation accelerates the progression of calcification, which has molecules in common with bone metabolism. For example, osteopontin (OPN), osteoprotegerin (OPG), receptor …

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A sodium-glucose co-transporter 2 inhibitor empagliflozin prevents abnormality of circadian rhythm of blood pressure in salt-treated obese rats

Yui Takeshige, Yoshihide Fujisawa, Asadur Rahman, Wararat Kittikulsuth et autres

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Effect of Angiotensin II Receptor Blocker on Cardiac Autonomic Activity in Patients with Chronic Heart Failure

S Ishikawa, Takahisa Noma, Keiji Matsunaga, Kaoru Mantani et autres

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Intracoronary administration of nicorandil during primary percutaneous coronary intervention: Impact on restoration of regional myocardial perfusion in reperfused myocardium during the subacute phase of myocardial infarction

Wataru Takabatake, Takahisa Noma, Yasuyoshi Iwado, S Ishikawa et autres

The impact of nicorandil as adjunctive therapy for percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) is controversial. We performed 15O-labeled water positron emission tomography (PET) to quantify regional myocardial perfusion in patients with STEMI who received nicorandil or …

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Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes

Arif Ul Hasan, Koji Ohmori, K. Konishi, Junsuke Igarashi et autres

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Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats

Abu Sufiun, Kazi Rafiq, Yoshihide Fujisawa, Asadur Rahman et autres

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Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity

Arif Ul Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori et autres

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Prognostic Value of Circulating Regulatory T Cells for Worsening Heart Failure in Heart Failure Patients With Reduced Ejection Fraction

Naoko Okamoto, Takahisa Noma, Yasuhiro Ishihara, Yuka Miyauchi et autres

Regulatory T cells (Tregs) play a crucial role in the negative regulation of immune responses. Recent studies suggest that Tregs are involved in the pathogenesis of atherosclerosis and myocarditis. Here, we investigated the involvement of Tregs on worsening heart failure (HF) in …

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The cyclin-dependent kinase inhibitor p21 is essential for the beneficial effects of renal ischemic preconditioning on renal ischemia/reperfusion injury in mice

Satoshi Nishioka, Daisuke Nakano, Kento Kitada, Tadashi Sofue et autres

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