Sun K. Kim

PolyQ-Expansion of Ataxin-2 Disrupts Microtubule Stability and Impairs Axon Outgrowth

Sun K. Kim, Vladimir I. Gelfand

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by mislocalization and aggregation of proteins in motor neurons. Ataxin-2 (ATXN2), an RNA-binding protein harboring 22-polyglutamine (polyQ) repeats, is a risk factor for ALS, when its polyQ repeats are expanded to 27–33 …

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AI-driven Automation of End-to-end Assessment of Suturing Expertise

Atharva Deo, Nicholas Matsumoto, Sun K. Kim, Peter Wager et autres

We present an AI based approach to automate the End-to-end Assessment of Suturing Expertise (EASE), a suturing skills assessment tool that comprehensively defines criteria around relevant sub-skills.1 While EASE provides granular skills assessment related to suturing to provide trainees with an objective …

Taxonomy and Analysis of Sensitive User Queries in Generative AI Search System

Hwiyeol Jo, Taiwoo Park, Hyunwoo Lee, Nayoung Choi et autres

Hwiyeol Jo, Taiwoo Park, Hyunwoo Lee, Nayoung Choi, Changbong Kim, Ohjoon Kwon, Donghyeon Jeon, Eui-Hyeon Lee, Kyoungho Shin, Sun Suk Lim, Kyungmi Kim, Jihye Lee, Sun Kim. Findings of the Association for Computational Linguistics: NAACL 2025. 2025.

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Ataxin-2–mediated regulation of microtubule stability and its disruption by polyQ expansion

Sun K. Kim

EB-SUN, a New Microtubule Plus-End Tracking Protein in Drosophila.

Wen Lü, Stephen L. Rogers, Vladimir I. Gelfand, Sun K. Kim et autres

Microtubule (MT) regulation is essential for oocyte development. In

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α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure

Yuou Wang, Alex Yemelyanov, Christopher Go, Sun K. Kim et autres

Epithelial cells can become polyploid upon tissue injury, but mechanosensitive cues that trigger this state are poorly understood. Using an Madin Darby Canine Kidney (MDCK) cell knock-out/reconstitution system, we show that α-catenin mutants that alter force-sensitive binding to F-actin or middle (M)-domain …

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EB-SUN, a new microtubule plus-end tracking protein in Drosophila

Sun K. Kim, Stephen L. Rogers, Wen Lü, Brad S. Lee et autres

Microtubule (MT) regulation is essential for oocyte development. In Drosophila, MT stability, polarity, abundance, and orientation undergo dynamic changes across developmental stages. In our effort to identify novel microtubule-associated proteins that regulate MTs in the Drosophila ovary, we identified a previously uncharacterized …

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EB-SUN, a New Microtubule Plus-End Tracking Protein in Drosophila

Sun K. Kim, S. Rogers, Wen Lü, Brad S. Lee et autres

Abstract Microtubule (MT) regulation is essential for oocyte development. In Drosophila , MT stability, polarity, abundance, and orientation undergo dynamic changes across developmental stages. In our effort to identify novel microtubule-associated proteins (MAPs) that regulate MTs in the Drosophila ovary, we identified …

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The Psychological Characteristics of Children in the Rewriting of the Folktale “Saekki Soe Bal” For Fifth Graders in Elementary School

Sun K. Kim, Eun Sang Joe

이 연구는 초등학교 5학년이 작성한 <새끼 서 발> 다시쓰기 178편의 서사적 특성을 확인하고 양상에 따른 심리적 의미를 탐색하여 대상 아동을 보다 포괄적으로 이해하는 것을 목적으로 한다. 이를 위해 경기도 Y시의 A 초등학교와 경기도 U시의 B 초등학교의 7개 학급을 대상으로 동일한 프로그램을 반복 …

Taxonomy and Analysis of Sensitive User Queries in Generative AI Search

Hwiyeol Jo, Taiwoo Park, Hyunwoo Lee, Nayoung Choi et autres

Although there has been a growing interest among industries in integrating generative LLMs into their services, limited experience and scarcity of resources act as a barrier in launching and servicing large-scale LLM-based services. In this paper, we share our experiences in developing …

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

Yuou Wang, Alex Yemelyanov, Christopher D. Go, Sun K. Kim et autres

ABSTRACT Epithelial cells can become polyploid upon tissue injury, but mechanosensitive cues that trigger this state are poorly understood. Using α-catenin (α-cat) knock-out Madin Darby Canine Kidney (MDCK) cells reconstituted with wild-type and mutant forms of α-cat as a model system, we …

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Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion

Rosa Ventrella, Sun K. Kim, Jennifer G. Sheridan, Aline Grata et autres

Xenopus embryos are covered with a complex epithelium containing numerous multiciliated cells (MCCs). During late-stage development, there is a dramatic remodeling of the epithelium that involves the complete loss of MCCs. Cell extrusion is a well-characterized process for driving cell loss while …

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