Peipei Miao

The mechanism of ncRNA in trastuzumab resistance in HER2-positive tumors

Huan Zhao, Huihui Hu, Zhifei Li, Ming Xu et autres

cn (code pays fourni par la source)

Inhibition of Skp2 enhances anti-tumor immunity of macrophages by regulating CD47 in gastric cancer

Kaizhao Hu, Lidan Zhao, Peipei Miao, Wenhui Qiu et autres

cn, nz (code pays fourni par la source)

Molecular hybridization strategy - discovery of 2,3-diarylpyrazine derivatives as potent Skp2 inhibitors with improved anti-tumor activity and enhanced cisplatin sensitivity

Kaizhao Hu, Kun Zhang, Rui-Hao Chui, Wenhui Qiu et autres

nz, cn (code pays fourni par la source)

PKLR-Modulating Compounds Show Promising Effects for the Treatment of Hepatocellular Carcinoma

Woonghee Kim, Han Young Jin, Peipei Miao, Mehmet Özcan et autres

se, cn, tr, Kenya (code pays fourni par la source)

PKLR-modulating compounds show promising effects for the treatment of hepatocellular carcinoma

Adil Mardinoğlu, Woonghee Kim, Han Young Jin, Peipei Miao et autres

se, cn, tr, gb, Maroc (code pays fourni par la source)

Discovery of Novel [1,2,4]Triazolo[1,5-a]pyrimidine Derivatives as Novel Potent S-Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer

Kaizhao Hu, Yong‐Qiang Luo, Peipei Miao, Lidan Zhao et autres

Skp1-CUL1-ROC1-F-box E3 ubiquitin ligases’ main component S-phase kinase-associated protein 2 (Skp2) is responsible for specifically recognizing ubiquitination-modified substrates to be degraded such as p27 and p21 in the case of binding with adaptor protein Cks1. Pharmacological inhibition of Skp2 has exhibited promising …

cn (code pays fourni par la source)

Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway

Ying Lei, Na Li, Zhengyue He, Xueqin Zeng et autres

Endothelial dysfunction initiates and exacerbates hypertension, atherosclerosis and other cardiovascular complications in diabetic mellitus. FGF21 is a hormone that mediates a number of beneficial effects relevant to metabolic disorders and their associated complications. Nevertheless, it remains unclear as to whether FGF21 ameliorates …

cn (code pays fourni par la source)

In vitro effects of Genkwa Flos chloroform extract on activity of human liver microsomes UGTs and UGT1A1

Ning Chen, Peipei Miao, Chang‐E Guo, Hongying Chen et autres

To predict the mechanism of liver injury induced by Genkwa Flos, we investigated the effect of chloroform extract on UGTs and UGT1A1 activities of the liver microsomes in rat and human. In the present study, 4-nitrophenol(4-NP) and β-estradiol were elected as substrates …

cn (code pays fourni par la source)

In Vitro Intestinal Absorption and Metabolism of Magnoflorine and its Potential Interaction in Coptidis Rhizoma Decoction in Rat

Bao-Juan Xue, Yuan-Yuan Zhao, Jin Su, Qing Miao et autres

cn (code pays fourni par la source)

Inhibitory effect of different species of hydroxygenkwanin on UGTs and UGT1A1 activities

Peipei Miao, Yuan-Yuan Zhao, Qing Miao, Chang‐E Guo et autres

To predit the mechanism of metabolic drug-drug interactions of hydroxygenkwanin with other drugs, we investigated the inhibition inhibitory effect of hydroxygenkwanin on UGTs and UGT1A1 activities of different liver microsomes. In the present study, 4-nitrophenol (4-NP) and β-estradiol were elected as substrates …

cn (code pays fourni par la source)

In vitropotential modulation of baicalin and baicalein on P-glycoprotein activity and expression in Caco-2 cells and rat gut sacs

Qing Miao, Zhiyong Wang, Yuanyuan Zhang, Peipei Miao et autres

Context Previous studies have shown that Scutellariae Radix, the dried root of Scutellaria baicalensis Georgi (Labiatae), has a certain inhibitory effect on P-glycoprotein (P-gp), but the effects of its main active constituents on P-gp are still ambiguous. Objectives In vitro studies were …

cn (code pays fourni par la source)

In vitro and In vivo effects of six Coptidis alkaloids on liver microsomes UGTs and UGT1A1 activities in rats and mice

Yuan-Yuan Zhao, Peipei Miao, Qing Miao, Chang‐E Guo et autres

In the present study, the effects of six Coptidis alkaloids (berberine, epiberberine, coptisine, jatrorrhizine, palmatine and magnoflorine) on liver microsomes UGTs and UGT1A1 activities in rats and mice were investigated in vitro and in vivo to study the mechanism of metabolic drug-drug …

cn (code pays fourni par la source)