Qian‐Wei Luo

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m 6 A‐IGF2BP1 for Ischemic Stroke Rescue

Ling Li, Xiaowen Zhang, Zhiyong Du, Yi Wang et autres

Abstract Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) mediates stress granules (SGs) via phase separation. However, there is limited understanding of the allosteric mechanism and the identification of regulatory molecules. Here, we identify icariin (ICA), a small‐molecule inducer that promotes G3BP1‐driven biomolecular …

cn (code pays fourni par la source)

Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023)

Zhuo Yang, Xiaowen Zhang, Fang‐Fang Zhuo, Tingting Liu et autres

Allosteric Activation of Transglutaminase 2 Transglutaminase 2 (TGM2) serves as a cellular target of small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy-induced osteoporosis. Forskolin binds to TGM2 on a previously undisclosed allosteric site to activate TGM2 by inducing an “open” …

Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation

Zhuo Yang, Xiaowen Zhang, Fang‐Fang Zhuo, Tingting Liu et autres

Osteoblasts play an important role in the regulation of bone homeostasis throughout life. Thus, the damage of osteoblasts can lead to serious skeletal diseases, highlighting the urgent need for novel pharmacological targets. This study introduces chemical genetics strategy by using small molecule …

cn (code pays fourni par la source)

Inherent Capability of Self‐Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis (Small 9/2023)

Qian‐Wei Luo, Yao Lü, Ling Li, Zhuo Yang et autres

Cancer Cell Pyroptosis In article number 2205531, Ke-Wu Zeng and co-workers describe the natural product oleanolic acid-based self-assembling nanostructures specially bind to proteasome subunit alpha 6 (PSMA6) to activate proteasome for cancer cell pyroptosis. This study opens up a new direction for …

cn (code pays fourni par la source)

Inherent Capability of Self‐Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis

Qian‐Wei Luo, Yao Lü, Ling Li, Zhuo Yang et autres

Understanding the direct interaction of nanostructures per se with biological systems is important for biomedical applications. However, whether nanostructures regulate biological systems by targeting specific cellular proteins remains largely unknown. In the present work, self-assembling nanomicelles are constructed using small-molecule oleanolic acid …

cn (code pays fourni par la source)