Zhuo Yang

Triptolide induces ferroptosis in lung adenocarcinoma cell by modulating lipid metabolism pathways

Zhuo Yang, Ziyi Zhou, Lanlan Yang, Xiangyu Ren et autres

To investigate the mechanism by which Triptolide (TPL) regulates ferroptosis in lung cancer cells through a comprehensive approach integrating network pharmacology, molecular docking, molecular dynamics simulations, and in vitro validation. The CCK-8 assay was initially used to examine the inhibitory effects of …

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A prognostic model integrating systemic inflammation and clinical features for overall survival in lung cancer: development, internal validation, and external evaluation

Lingge Yang, Wei Liu, Quan Xie, Xiaofang Wang et autres

Conventional clinicopathological factors do not fully capture host-related influences on lung cancer survival. We developed and externally evaluated a prognostic model integrating systemic inflammatory markers with routine clinical characteristics for overall survival (OS). The development cohort comprised 272 single-center patients with pathologically …

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Modified cardiovascular-kidney-metabolic stages and stroke-death transitions in middle-aged and older Chinese adults: a multistate Markov analysis of CHARLS

Shikun Li, Xu Chen, Rudong Chen, Zhuo Yang et autres

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Global and individual-level inequalities in cardiometabolic risk and stroke burden: evidence from GBD 2023, CHARLS, HRS, and NHANES

Shikun Li, Xu Chen, Rudong Chen, Zhuo Yang et autres

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Altered eating experience during GLP-1 receptor agonist therapy: a sensory–liking–wanting framework for food preference and nutritional behaviour

Jiayi Du, Zhuo Yang, Yan Chen

Eating experience is shaped not only by oral sensory input, but also by hedonic evaluation, interoceptive state, and cue-driven motivation. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), widely used for obesity treatment, offer a clinically relevant model for examining how these processes interact during …

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Predicting the risk of unplanned cesarean delivery at admission to guide labor process management: a retrospective cohort study in Southwest China

Zhuo Yang, Huicong Zhang, Yue Zheng, Shufang Chang et autres

BACKGROUND: Following the implementation of the three-child policy in China, an increasing number of pregnant people prefer vaginal delivery over cesarean delivery. However, concerns about unplanned cesarean delivery during labor have increased the demand for a quantitative risk assessment tool. Therefore, developing …

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MTHFR rs1801131 GG Genotype Combined with Serum LDH Level Predicts Lung Adenocarcinoma Susceptibility and Poor Prognosis in Guangxi Zhuang Population

Chao Zuo, Yuanyuan Wang, Dongli Yang, Jing Cheng et autres

Introduction Methylenetetrahydrofolate reductase (MTHFR) polymorphisms modulate folate metabolism and carcinogenesis, yet their role in lung adenocarcinoma (LUAD) susceptibility and prognosis, particularly in underrepresented populations, remains unclear. Methods We conducted a retrospective case-control study of 306 lung cancer (LC) patients (predominantly LUAD) and …

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Molecular glue neferine induces BAP31 homodimerisation to disrupt endoplasmic reticulum–mitochondria crosstalk for anti‐neuroinflammation in ischaemic stroke

Ya‐Xuan Zhu, Zhuo Yang, Ling Li, Fang‐Fang Zhuo et autres

BACKGROUND AND PURPOSE: B-cell receptor-associated protein 31 (BAP31), an endoplasmic reticulum (ER)-resident transmembrane protein, has emerged as a critical regulator of immune cell activation, yet its role in neuroinflammation remains unexplored. Here, we uncovered the natural compound neferine (Nef) as a pharmacological …

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Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m 6 A‐IGF2BP1 for Ischemic Stroke Rescue

Ling Li, Xiaowen Zhang, Zhiyong Du, Yi Wang et autres

Abstract Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) mediates stress granules (SGs) via phase separation. However, there is limited understanding of the allosteric mechanism and the identification of regulatory molecules. Here, we identify icariin (ICA), a small‐molecule inducer that promotes G3BP1‐driven biomolecular …

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Cost-effectiveness of edaravone dexborneol sublingual tablet versus concentrated solution for injection for the treatment of acute ischemic stroke in China

Fan Xie, Yuqiong Lu, Zhuo Yang, Yanlei Zhang et autres

Background: Edaravone dexborneol sublingual tablet (EDSL) is a novel therapy for acute ischemic stroke (AIS), proven effective and safe. Its convenient dosage form also provides an alternative administration option, helping to enhance treatment accessibility. This study evaluates the cost-effectiveness of EDSL versus …

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VEGFA ‐centric angiogenic genetic variants drive hypertension and dyslipidaemia susceptibility in type 2 diabetes mellitus: A multilocus synergistic cohort study

Chao Zuo, Hailian Chen, Xiang Lu, Jing Cheng et autres

BACKGROUND: The interplay between angiogenic genetic variants and metabolic-vascular comorbidities in type 2 diabetes mellitus (T2DM) remains poorly elucidated. This cohort study investigated the synergistic effects of VEGFA-centric polymorphisms on hypertension (HTN) and dyslipidaemia (DYS) susceptibility in T2DM. METHODS: We enrolled 440 …

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202 CER-1236, an investigational T cell product targeting TIM-4 Ligand, exhibits sustained effector function and resistance to exhaustion

Ankit Bhatta, Bi Yu, Zhuo Yang, Edson Oliveira et autres

Background A major hurdle for effective engineered T cell therapies for solid tumors indications is the identification and targeting of a tumor-associated antigen that is expressed across heterogeneous tumor sub-types but not in healthy tissue. Disruption of the lipid bilayer asymmetry is …

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