Maria Carmen Garganese

Italian Association of Nuclear Medicine, Molecular Imaging and Therapy (AIMN) practical guide for radiopharmaceutical imaging in neuroblastoma. The role of nuclear medicine imaging in neuroblastoma management

Priscilla Guglielmo, Michela Allocca, Domenico Albano, Alfredo Campennì et autres

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Peptide receptor radionuclide therapy with 177 Lu-DOTATATE in pediatric, adolescent, and young adult neuroendocrine tumors: A single-center experience from Bambino Gesù Children’s Hospital.

Maria Debora De Pasquale, Evelina Miele, Aurora Castellano, Milena Pizzoferro et autres

10027 Background: Neuroendocrine tumors (NETs) in pediatric, adolescent, and young adult (AYA) patients are rare and often associated with hereditary syndromes such as Von Hippel Lindau (VHL) and type 1 neurofibromatosis (NF1). Peptide receptor radionuclide therapy (PRRT) with ^177Lu-DOTATATE is well established …

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Imaging of High‐Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

Annemieke Simone Littooij, Catia Olianti, Hervé J. Brisse, Pier Luigi Di Paolo et autres

Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty …

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Deep learning for synthetic PET imaging: a systematic mapping review of techniques, metrics, and clinical relevance

Maria Vaccaro, Enrico Rosa, Elisa Placidi, A. Guarnera et autres

BACKGROUND: Synthetic positron emission tomography (PET) imaging, enabled by deep learning, represents a promising approach to minimize radiation exposure while preserving diagnostic accuracy. However, variability in methodologies, performance metrics, and clinical applications needs to be assessed. This systematic mapping review examines the …

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18F-FDG PET/CT: bicuspid aortic valve patients’ underestimated ally. A systematic review

Elizabeth Katherine Anna Triumbari, Emanuele Casciani, Andrea Guarneri, Saadi Sollaku et autres

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Epigenomic characterization and therapeutic challenges of melanoma arising in giant nevi in pediatric patients

Evelina Miele, Sabrina Rossi, Alessandra Stracuzzi, Sara Patrizi et autres

BACKGROUND: Congenital giant melanocytic nevi (CGMN) are rare melanocytic proliferations present at birth, associated with an increased risk of pediatric malignant melanoma (MM). Melanomas arising within CGMN are uncommon but clinically aggressive, with diagnostic challenges due to overlapping histopathological features with benign …

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Optimizing Glomerular Filtration Rate Estimation: A Simplified Method for Improved Accuracy and Efficiency

E. Solfaroli Camillocci, Davide Ciucci, Claudia Polito, Salvatore Donatiello et autres

The glomerular filtration rate (GFR) is a key measure of renal function, typically estimated using creatinine-based equations. More precise clearance measurements are obtained with radiotracers, such as [99mTc]Tc-diethylenetriaminepentaacetic acid (DTPA), and blood samples over several hours. However, standard plasma clearance methods require …

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Donor-derived GD2-specific CAR T cells in relapsed or refractory neuroblastoma

Concetta Quintarelli, Francesca Del Bufalo, Maria Antonietta De Ioris, Marika Guercio et autres

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131I-mIBG therapy in relapsed/refractory neuroblastoma: A weapon from the future past

Francesco Fabozzi, Maria Felicia Villani, Francesca Del Bufalo, Claudio Altini et autres

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18F-FDG PET/CT: The turning point in eosinophilic fasciitis diagnosis in a pediatric patient

Elizabeth Katherine Anna Triumbari, Milena Pizzoferro, Maria Felicia Villani, Claudio Altini et autres

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Congenital Hyperinsulinism of a Large Italian Cohort: A Retrospective Study

Francesco Tagliaferri, Roberta Iannuzzi, Gabriele Canciani, Silvia Maria Bernabei et autres

INTRODUCTION: To evaluate and describe the diagnostic process, medical, nutritional, and surgical approach, and neurological outcome, we report data from a large Italian cohort of patients with congenital hyperinsulinism (CHI). METHODS: We retrospectively analyzed 154 CHI patients admitted to Ospedale Pediatrico Bambino …

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Gastrointestinal radionuclide imaging in pediatric age group

Maria Carmen Garganese, Milena Pizzoferro

Pediatric gastrointestinal imaging plays a crucial role in evaluating and managing digestive system disorders in children. This comprehensive review dives into the nuances of pediatric gastrointestinal imaging techniques, focusing on three specific modalities: gastric emptying scintigraphy (GES), intestinal transit scintigraphy (ITS), and …

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