Marika Guercio

CD19 antigen: from tumor target to safety switch in CAR-T cell therapy

Simona Manni, Laura Iaffaldano, Maria Cecilia Quadraccia, Mariasole Aurigemma et autres

Not available.

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Furuncular myiasis by Cordylobia anthropophaga in three Italian children: First case series and implications for non-endemic regions

Livia Mancinelli, Marika Guercio, Gianluca Vrenna, Manuela Onori et autres

Cordylobia anthropophaga, commonly known as the tumbu fly, is a leading cause of cutaneous myiasis in sub-Saharan Africa. This condition is characterized by a papulopustular lesion that evolves in a painful boil-like nodule with central ulceration. Human infestations typically occur on covered …

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Engineering and clinical translation of CD19-CAR T cell therapy for pediatric BCP-ALL: from safety optimization to single-cell dissection of in vivo persistence

Marika Guercio

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common malignancy in childhood and young adulthood. CD19-directed chimeric antigen receptor (CAR) T-cell therapy has transformed outcomes in the relapsed/refractory setting, yet important challenges remain: manufacturing failures and long vein-to-vein times, toxicity management, …

CD19 antigen: From tumor target to safety switch able to improve the safety profile of CAR T cell therapy

Simona Manni, Laura Iaffaldano, Maria Cecilia Quadraccia, Mariasole Aurigemma et autres

Abstract Background Chimeric antigen receptor (CAR) T cell therapy is an innovative immunotherapeutic approach that has shown a potent and durable anti-tumor effect in hematologic malignancies, such as B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin lymphoma, and multiple myeloma.More recently, …

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A novel B7-H3-specific binder enables effective CAR T-cell therapy in an Acute Myeloid Leukemia experimental model

Pamela De Falco, Alessio Ottaviani, Michele Veneruso, Marilena Margiotta et autres

Abstract Background Acute myeloid leukemia (AML) is due to the clonal expansion of myeloid precursor cells driven by recurrent genetic alterations, leading to their uncontrolled proliferation and accumulation. The genomic heterogeneity of AML poses significant therapeutic challenges. Despite advances in treatment and …

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Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial

Franco Locatelli, Daria Pagliara, Maria Antonietta De Ioris, Marco Becilli et autres

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GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial

Franco Locatelli, Daria Pagliara, Maria Antonietta De Ioris, Marco Becilli et autres

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Truncated form of human CD19 antigen as a suicide gene to control T-cell alloreactivity: ΔCD19

Simona Manni, Laura Iaffaldano, Marika Guercio, Pietro Merli et autres

Donor lymphocyte infusion (DLI) is employed to either treat or prevent relapse in patients with hematologic malignancies, as well as to accelerate recovery of adaptive immunity, after allogeneic hematopoietic stem cell transplantation (allo-HSCT). With the increased use of DLI, there is renewed …

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Donor-derived GD2-specific CAR T cells in relapsed or refractory neuroblastoma

Concetta Quintarelli, Francesca Del Bufalo, Maria Antonietta De Ioris, Marika Guercio et autres

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Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells

Michele Pezzella, Concetta Quintarelli, Maria Cecilia Quadraccia, Andrea Sarcinelli et autres

Sarcomas are rare, mesenchymal tumors, representing about 10–15% of all childhood cancers. GD2 is a suitable target for chimeric antigen receptor (CAR) T-cell therapy due to its overexpression in several solid tumors. In this preclinical study, we investigated the potential use of …

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Humoral and cellular immune response after mRNA SARS-CoV-2 vaccine in children on treatment for cancer: A pilot observational study

Angela Mastronuzzi, Rita Carsetti, Maria Antonietta De Ioris, Chiara Agrati et autres

Immunocompromised children are at risk of developing severe COVID-19 infection. We conducted a pilot prospective study to evaluate the impact of cancer treatment and stem cell transplantation on immunogenicity of two doses of BNT162b2 vaccine in pediatric patients. Humoral, B- and T-cell …

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Supplemental Figure 12 from GD2-Targeting CAR T-cell Therapy for Patients with GD2+ Medulloblastoma

Roselia Ciccone, Concetta Quintarelli, Antonio Camera, Michele Pezzella et autres

Supplemental Figure 12. DAOY-GFP tumor bearing-mice treated with Tazemetostat to evaluate GD2 upregulation in vivo.