Yuejia Liu

Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

Jason Siputro, Omar Ahmad, Mark A. Rossi, Marcus L. Basiri et autres

Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using …

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Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

Koichi Hashikawa, Yoshiko Hashikawa, Brandy A. Briones, Kentaro K. Ishii et autres

Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using …

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Author response: Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

Koichi Hashikawa, Yoshiko Hashikawa, Brandy A. Briones, Kentaro K. Ishii et autres

The authors test the hypothesis that gonadal steroid signaling influences the transcriptional development of specific neurons in the mPOA during adolescence, and that such adolescent development of the mPOA is necessary for mating behaviors.The valuable findings are supported by convincing evidence.This work …

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Long-term nitrogen addition weakens the CH4 sink in temperate forest soils by inhibiting methane oxidation and promoting methanogenesis

Ziyi Ma, Yuejia Liu, C WANG, Minghua Song et autres

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Warming and N addition amplify alpine peatland N2O emissions via divergent microbial and nutrient pathways

Xiaoqing Liu, Yuejia Liu, Chunmei Wang, Minghua Song et autres

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Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula

Yoshiko Hashikawa, Marcus L. Basiri, Omar R. Ahmad, Garret D. Stuber et autres

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Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area

Garret D. Stuber, Yoon Seok Kim, Yuejia Liu, Koichi Hashikawa et autres

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PIEZO channels link mechanical forces to uterine contractions in parturition

Yunxiao Zhang, Sejal A Kini, Sassan A Mishkanian, Oleg V. Yarishkin et autres

Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. We identified mechanically activated ion channels PIEZO1 and PIEZO2 as key mechanotransducers required for labor progression. Genetic deletion of Piezo1 and Piezo2 in mice …

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Urbanization weakens soil carbon stocks but enhances carbon stability through coupled physicochemical and microbial mechanisms in Beijing urban-rural forests

Dan Liu, Yuejia Liu, Chunmei Wang, Minghua Song et autres

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PIEZO channels link mechanical forces to uterine contractions in parturition

Yunxiao Zhang, Sejal A Kini, Sassan A Mishkanian, Saba Heydari Seradj et autres

Abstract Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 and PIEZO2 as key mechanotransducers required for labor progression. Genetic deletion of Piezo1 and Piezo2 …

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Long-term nitrogen addition enhanced soil carbon sequestration through coupled physicochemical and microbial mechanisms in a temperate forest

Yuejia Liu, Xiaomin Dou, Chunmei Wang, Minghua Song et autres

As critical carbon (C) sinks in terrestrial ecosystems, temperate forests exhibit complex responses to atmospheric nitrogen (N) deposition. Through a 13-year controlled field experiment, we systematically investigated the effects of three N forms (NO 3 − -N, NH 4 + -N, NH …

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A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy

Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu et autres

Chemotherapy remains the primary treatment for pancreatic ductal adenocarcinoma (PDAC), but most patients ultimately develop resistance. Here, we established 260 pancreatic cancer organoid lines, followed by extensive multi-omics profiling and therapeutic sensitivity assessments. Integrated analyses uncovered 6 novel coding and 35 noncoding …

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