Kentaro K. Ishii

A cholinergic eligibility trace facilitates amygdala plasticity in flavour avoidance learning

Weston Fleming, Jordan L. Pauli, Kentaro K. Ishii, Marta Trzeciak et autres

Summary When an animal consumes a new food and consequently feels ill, it rapidly and robustly learns to avoid this food in the future, a form of learning termed conditioned flavour avoidance (CFA). Postingestive malaise often occurs long after novel food consumption, …

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Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

Jason Siputro, Omar Ahmad, Mark A. Rossi, Marcus L. Basiri et autres

Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using …

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Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

Koichi Hashikawa, Yoshiko Hashikawa, Brandy A. Briones, Kentaro K. Ishii et autres

Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using …

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Author response: Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

Koichi Hashikawa, Yoshiko Hashikawa, Brandy A. Briones, Kentaro K. Ishii et autres

The authors test the hypothesis that gonadal steroid signaling influences the transcriptional development of specific neurons in the mPOA during adolescence, and that such adolescent development of the mPOA is necessary for mating behaviors.The valuable findings are supported by convincing evidence.This work …

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Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice

Carlie Neiswanger, Lukas K. MacMillen, Alexandria D. Murry, Eric R Szelenyi et autres

Abstract Emergence from general anesthesia, defined by a recovery of consciousness to the wakeful state, is a clinically consequential state transition that remains a passive process dependent on drug clearance. Despite the critical use of anesthesia, the neural circuitry underlying behavioral recovery …

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Author Response: Esr1-Dependent Signaling and Transcriptional Maturation in the Medial Preoptic Area of the Hypothalamus Shapes the Development of Mating Behavior during Adolescence

Koichi Hashikawa, Yoshiko Hashikawa, Brandy A. Briones, Kentaro K. Ishii et autres

Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using …

Hierarchical and Spatial Mapping of Whole-Brain c-Fos Activity Reveals Distinct Opioid and Withdrawal Neuronal Ensembles

Kentaro K. Ishii, Yizhe Y. Zhang, Lynn Y. Ren, Alex De Lecea et autres

Summary How opioid exposure and withdrawal states shape brain activity at the systems and circuit level remains poorly understood. Here, we use whole-brain, cellular-resolution c-Fos mapping to define brain-wide activity patterns and neuronal ensembles associated with morphine administration and withdrawal. To account …

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Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal

Rhiana C. Simon, Weston Fleming, Brandy A. Briones, Marta Trzeciak et autres

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Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

Koichi Hashikawa, Yoshiko Hashikawa, Brandy A. Briones, Kentaro K. Ishii et autres

Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using …

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Esr1-Dependent Signaling and Transcriptional Maturation in the Medial Preoptic Area of the Hypothalamus Shapes the Development of Mating Behavior during Adolescence

Koichi Hashikawa, Yoshiko Hashikawa, Brandy A. Briones, Kentaro K. Ishii et autres

Abstract Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, …

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Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble

Kevin N. Schneider, Minke H.C. Nota, Hallie Lazaro, Daniel Ryskamp Rijsketic et autres

Neural circuits underlying unconsciousness remain poorly defined. We test the hypothesis that unconsciousness arises from specific, distributed circuits using general anesthesia in mice as a reproducible model. We identify a cortical-to-subcortical shift in neural activity during isoflurane anesthesia that is organized into …

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Author response: Post-ejaculatory inhibition of female sexual drive via heterogeneous neuronal ensembles in the medial preoptic area

Kentaro K. Ishii, Koichi Hashikawa, Jane Chea, Shihan Yin et autres

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