Dhiraj Indana

BPS2026 – Nuclear deformations and epigenomic remodeling during maturation of a human epiblast model

Alex Esclamado, Dhiraj Indana, Junqin Zhu, Michael Bassik et autres

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BPS2026 – Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

Kolade Adebowale, Cole Allan, Byunghang Ha, Aashrith Saraswathibhatla et autres

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

Kolade Adebowale, Cole Allan, Byung Hang Ha, Aashrith Saraswathibhatla et autres

Circulating monocytes are recruited to the tumor microenvironment, where they can differentiate into macrophages that mediate tumor progression. To reach the tumor microenvironment, monocytes must first extravasate and migrate through the type-1 collagen rich stromal matrix. The viscoelastic stromal matrix around tumors …

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Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model

Dhiraj Indana, A. P. Zakharov, Youngbin Lim, Alexander R. Dunn et autres

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Cell volume expansion and local contractility drive collective invasion of the basement membrane in breast cancer

Julie Chang, Aashrith Saraswathibhatla, Zhaoqiang Song, Sushama Varma et autres

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Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

Kolade Adebowale, Byung Hang Ha, Aashrith Saraswathibhatla, Dhiraj Indana et autres

Abstract Circulating monocytes are recruited to the tumor microenvironment, where they can differentiate into macrophages that mediate tumor progression. To reach the tumor microenvironment, monocytes must first extravasate and migrate through the type-1 collagen rich stromal matrix. The viscoelastic stromal matrix around …

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Actin polymerization drives lumen formation in a human epiblast model

Dhiraj Indana, A. P. Zakharov, Youngbin Lim, Alexander R. Dunn et autres

Summary Lumens or fluid-filled cavities are a ubiquitous feature of mammals and are often evolutionarily linked to the origin of body-plan complexity. Post-implantation, the pluripotent epiblast in a human embryo forms a central lumen, paving the way for gastrulation. While osmotic pressure …

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Cell–extracellular matrix mechanotransduction in 3D

Aashrith Saraswathibhatla, Dhiraj Indana, Ovijit Chaudhuri

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Viscoelasticity and Adhesion Signaling in Biomaterials Control Human Pluripotent Stem Cell Morphogenesis in 3D Culture

Dhiraj Indana, Pranay Agarwal, Nidhi Bhutani, Ovijit Chaudhuri

Organoids are lumen-containing multicellular structures that recapitulate key features of the organs, and are increasingly used in models of disease, drug testing, and regenerative medicine. Recent work has used 3D culture models to form organoids from human induced pluripotent stem cells (hiPSCs) …

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Tuning Viscoelasticity in Alginate Hydrogels for 3D Cell Culture Studies

Frank W. Charbonier, Dhiraj Indana, Ovijit Chaudhuri

Physical properties of the extracellular matrix (ECM) affect cell behaviors ranging from cell adhesion and migration to differentiation and gene expression, a process known as mechanotransduction. While most studies have focused on the impact of ECM stiffness, using linearly elastic materials such …

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Magnetic probe-based microrheology reveals local softening and stiffening of 3D collagen matrices by fibroblasts

Juho Pokki, Iliana Zisi, Ester Schulman, Dhiraj Indana et autres

Changes in extracellular matrix stiffness impact a variety of biological processes including cancer progression. However, cells also actively remodel the matrices they interact with, dynamically altering the matrix mechanics they respond to. Further, cells not only react to matrix stiffness, but also …

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Cells under pressure

Dhiraj Indana, Ovijit Chaudhuri

A new method for applying solid stress to aggregates of cells is shedding light on the impact of mechanical forces on cancer cells.

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