Sushama Varma

Identification and Characterization of Neoplastic Cells in Keratin-Positive Giant Cell-Rich Tumors

Maarten van der Linde, John S.A. Chrisinger, Elizabeth G. Demicco, Carina A Dehner et autres

Abstract Keratin-positive giant cell-rich tumor (KPGCT) is a newly described bone and soft tissue tumor. The tumor is characterized by scattered keratin-positive cells and the presence of HMGA2::NCOR2 fusions. It is not known if the HMGA2::NCOR2 fusion is located in the keratin-positive …

nl, us, ca (code pays fourni par la source)

SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Stefano Testa, Aastha Pal, Ajay Subramanian, Sushama Varma et autres

BACKGROUND: The FDA approval of T cell receptor-engineered T cells (TCR-T) for synovial sarcoma demonstrates the potential for adoptive T cell therapies (ACTs) in solid tumors. However, the paucity of tumor-associated targets without expression in normal tissues remains a major bottleneck, especially …

us, gb, cn (code pays fourni par la source)

BSBM-12 IDENTIFYING A NOVEL GENE SIGNATURE FOR PREDICTING BRAIN METASTASIS RISK IN BREAST CANCER USING SPATIAL TRANSCRIPTOMICS

Maxine Umeh Garcia, Christine Y. Yeh, Bryanna Godfrey, Pablo Nunez Perez et autres

Abstract BACKGROUND Up to 50% of patients with advanced-stage breast cancer develop brain metastases (BrMets), a diagnosis associated with a median survival of just 10 months and significant neurologic decline. However, BrMet risk is not uniform among breast cancer patients, and despite …

us (code pays fourni par la source)

Supplementary Table 1 from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Patient demographics.

Figure S2 from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Epithelial cell substates

Figure S6 from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Expression of basement membrane genes

Figure S4 from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Cell state analysis

Supplementary Data from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Suppl Figure Legend

Data from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Abstract Ductal carcinoma in situ (DCIS) is a risk factor for subsequent invasive breast cancer (IBC). To identify events in DCIS that lead to invasive cancer, we performed single-cell RNA sequencing on DCIS lesions and matched normal breast tissue. Inferred copy-number variation …

Supplementary Table 2 from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Decision rules for CNV categorization.

Figure S5 from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

Bulk sample analysis

Figure S3 from Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition

Xiaodi Qin, Siri H. Strand, Marissa R. Lee, Aashrith Saraswathibhatla et autres

CNV phylogenetic trees