Chan Hee Gil

Multispectral Pulsed Photobiomodulation Enhances Re-Epithelialization via Keratinocyte Activation in Full-Thickness Skin Wounds

Joo-Hyun Kim, D BAATAR, Myung Jin Ban, Ji Won Son et autres

Chronic wound healing is a complex and tightly regulated process requiring coordinated epithelial and stromal regeneration. Photobiomodulation (PBM) using low-level red light-emitting diode (LED) therapy has emerged as a non-invasive approach to enhancing skin repair. In this study, we evaluated the therapeutic …

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Multispectral Pulsed Photobiomodulation Enhances Diabetic Wound Healing via Focal Adhesion-Mediated Cell Migration and Extracellular Matrix Remodeling

Myung Jin Ban, Chan Hee Gil, Sung Sik Hur, Laurensia Danis Anggradita et autres

Chronic diabetic wounds affect 15-20% of patients and are characterized by impaired healing due to disrupted hemostasis, inflammation, proliferation, and extracellular matrix (ECM) remodeling. Low-level light therapy (LLLT) has emerged as a promising noninvasive strategy for enhancing tissue regeneration. Here, we developed …

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NLRP3 inhibition attenuates the allergic rhinitis symptoms in a mouse model

Minhyung Lee, Youngkyung Ko, Sehun Jang, Chan Hee Gil et autres

BACKGROUND: Recent human and animal studies have demonstrated that Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is closely involved in the development of allergic diseases. OBJECTIVE: To identify the mechanism underlying the activation of NLRP3 inflammasome signaling pathway in an ovalbumin …

kr, Éthiopie, cn (code pays fourni par la source)

Inhalation Delivery of Interferon-λ-Loaded Pulmonary Surfactant Nanoparticles Induces Rapid Antiviral Immune Responses in the Lung

Chan Hee Gil, Chanhee Oh, Jeongsoo Lee, Mincheol Jang et autres

The interferon-λ (IFN-λ)-regulated innate immune responses in the airway expand our understanding toward antiviral strategies against influenza A virus (IAV). The application of IFN-λ as mucosal antiviral therapeutic is still challenging, and advanced research will be necessary to achieve more efficient delivery …

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NLRP3 inhibition attenuates the allergic rhinitis symptoms in an mice model

Minhyung Lee, Youngkyung Ko, Chan Hee Gil, Kyoung Mi Eun et autres

Abstract This study aimed to identify the mechanism underlying the activation of Nod-like receptor family, pyrin domain‐containing 3 (NLRP3) inflammasome signaling pathway in an ovalbumin (OVA)-induced allergic rhinitis (AR) mice model and to validate the effect of a specific inhibitor of the …

kr, Éthiopie, pr, cn (code pays fourni par la source)

Correction: Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis

Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo et autres

kr, Éthiopie, pr (code pays fourni par la source)

Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis

Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo et autres

BACKGROUND: Allergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and interleukin (IL)-33 is the potent inducer of Th2 inflammation in allergic nasal epithelium. Staphylococcus epidermidis is one of the most abundant colonizers of the healthy human …

kr, Éthiopie, pr (code pays fourni par la source)

Intranasal inoculation of IFN-λ resolves SARS-CoV-2 lung infection via the rapid reduction of viral burden and improvement of tissue damage

Haeun Shin, Su-Jin Kim, Ara Jo, Jina Won et autres

Introduction: The innate immune responses of upper airway could further our understanding toward antiviral strategies against SARS-CoV-2. We characterize the potential of interferon (IFN)-λ as an innate immune inducer for the rapid clearance of SARS-CoV-2 in the lung and the therapeutic efficacy …

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Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis

Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo et autres

Abstract Background Allergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and interleukin (IL)-33 is the potent inducer of Th2 inflammation in allergic nasal epithelium. Staphylococcus epidermidis is one of the most abundant colonizers of the healthy …

kr, Éthiopie (code pays fourni par la source)

Inhaled delivery of recombinant interferon-lambda restores allergic inflammation after development of asthma by controlling Th2- and Th17-cell-mediated immune responses

Jina Won, Ara Jo, Chan Hee Gil, Su-Jin Kim et autres

Remarkable progress has recently been achieved to identify the biological function and potential value of novel therapeutic targets for the effective control of allergic asthma. Interferon (IFN)-λ has been suggested to restrict chronic inflammation in the lungs of asthmatic mice and we …

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Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium

Ara Jo, Jina Won, Chan Hee Gil, Su Geun Kim et autres

Our recent study presented that human nasal commensal Staphylococcus epidermidis could potentiate antiviral immunity in the nasal mucosa through interferon-related innate responses. Here, we found that human nasal commensal S. epidermidis promoted protease-protease inhibitor balance in favor of the host and prevented …

kr, pr (code pays fourni par la source)

Chronic rhinosinusitis endotypes associate with distinct local cytokine milieus that shape the distribution of innate lymphoid cells

Young Gyun Ko, Min Ho Kim, Joo Yong Park, Chan Hee Gil et autres

The authors declare that they have no competing interests. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author …

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