Robert Hammond

A novel diagnostic technology rapidly detects the presence of infection and defines antimicrobial sensitivities in organisms typical for joint infection

Isabelle L. Cochrane, Roselline Gabriella Gunarto, Frank Alexander Schildberg, Dieter Christian Wirtz et autres

Aims Infective arthritis is rare, but serious. Timely treatment with appropriate antimicrobial therapy is potentially life- and limb-saving, but our ability to deliver this is limited by current laboratory practices, which confer a delay of several days before antimicrobial sensitivities are available. …

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Novel optical measurement technique for antimicrobial photodynamic therapy using Scattered Light Integrating Collector (SLIC)

Marianna Leite De Avellar, Hassan Hafeez, Robert Hammond, Ifor D. W. Samuel

Abstract Advancing new treatment modalities for microbial infections is a priority, given the threat of antimicrobial resistance. Current work includes the development of new non-traditional treatments, including antimicrobial photodynamic therapy (aPDT). Improvements in the field include innovative technologies that allow screening and …

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A Novel Approach for Tissue Analysis in Joint Infections Using the Scattered Light Integrating Collector (SLIC)

Elio Assaf, Cosmea F. Amerschläger, Vincent B. Nessler, Robert Ossendorff et autres

Total joint arthroplasty is among the most common surgical procedures performed worldwide, with frequency increasing due to demographic changes. Accelerating the diagnostic process using new techniques is crucial for effective therapy. This pilot study aims to test such innovative technology in the …

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Draft Genome Sequence of a non-tuberculous Mycobacterium Strain Isolated from a Clinical Urine Sample.

Joanna E. Rivas Ramos, Paul R. Johnston, Robert Hammond, Matthew T. G. Holden et autres

Here we report the draft sequence of a rapid-growing nontuberculous Mycobacterium isolated from a urine sample at the Scottish Mycobacteria Reference Laboratory (SMRL), Royal Infirmary of Edinburgh, UK. The reported Mycobacterium genome has a length of 6,749,454 bp, a GC content of …

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USE OF A SCATTERED LIGHT INTEGRATING COLLECTOR FOR POINT-OF-CARE TESTING TO DETECT BACTERIA IN FLUID SAMPLES FROM PROSTHETIC JOINT INFECTIONS OF THE HIP

Isabelle Cochrane, Adeel Akhtar, Robert Hammond, P. Walmsley

Infection complicates 0.5–1% of the 72,000 total hip replacements (THRs) undertaken annually in the UK. Early targeted antibiotic therapy has an impact on patient outcomes, however rapid treatment with narrow spectrum antibiotics is currently limited by the available methods of confirming infection …

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Photodynamic therapy for infection treatment through novel laminar flow fibre optics

Marianna L. De Avellar, Robert Hammond

Novel Method for the Rapid Establishment of Antibiotic Susceptibility Profiles in Bacterial Strains Linked to Musculoskeletal Infections Using Scattered Light Integrated Collector Technology

Damien Bertheloot, Vincent B. Nessler, Elio Assaf, Cosmea F. Amerschläger et autres

Bacterial antibiotic resistance is an important challenge that the healthcare system is continually battling and a major problem in the treatment of musculoskeletal infections such as periprosthetic joint infections. Current methods to identify infectious microbes and define susceptibility to antibiotics require two …

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Investigating the time to blood culture positivity: why does it take so long?

Kerry Falconer, Robert Hammond, Benjamin J. Parcell, Stephen H. Gillespie

Introduction. Bloodstream infections (BSIs) are one of the most serious infections investigated by microbiologists. However, the time to detect a BSI fails to meet the rapidity required to inform clinical decisions in real time. Gap Statement. Blood culture (BC) is considered the …

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COVID-19 Pathophysiology: Inflammation to Cardiac Injury

Robert Hammond, Peter Donnelly, Anthony R. M. Coates, Alexander Liu

Coronavirus disease 19 (COVID-19) is responsible for one of the worst pandemics in human history. The causative virus, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), can invade host cells in multiple organs by binding the angiotensin-converting enzyme (ACE) II expressed on …

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Innovative approaches to rapid antibiotic resistance testing

Robert Hammond

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An investigation of scattered light integrating collector technology for rapid blood culture sensitivity testing

Leila White, Robert Hammond, Robert John Shorten, Jeremy P. Derrick

Introduction. Sepsis rates are increasing, with Gram-negative organisms representing a large proportion of bloodstream infections. Rapid antibiotic administration, alongside diagnostic investigations, is required for the effective management of these patients. Gap statement. Current diagnostics take ~48 h for a final report; therefore, …

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The appropriateness of empirical antibiotic therapy in the management of symptomatic urinary tract infection patients—a cross-sectional study in Nairobi County, Kenya

Hellen A. Onyango, Derek James Sloan, Katherine Lisa Keenan, Mike Kesby et autres

Background: In low- and middle-income countries, symptomatic urinary tract infection (UTI) patients are often prescribed antibiotics without microbiological confirmation. UTIs caused by antibiotic-resistant bacteria are increasingly common, and this heightens the risk of empirical treatment failure. This study evaluates the appropriateness of …

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