COVID-19 Pathophysiology: Inflammation to Cardiac Injury
Rattachement africain : gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Coronavirus disease 19 (COVID-19) is responsible for one of the worst pandemics in human history. The causative virus, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), can invade host cells in multiple organs by binding the angiotensin-converting enzyme (ACE) II expressed on the cell surface. Once inside the host cell, viral replication takes place, leading to cellular disruption and the release of signal molecules that are recognised by the innate immune system. Innate immunity activation leads to the release of proinflammatory cytokines and primes the adaptive immune system. The proinflammatory environment defends against further viral entry and replication. SARS-CoV-2 infection is thought to lead to myocardial injury through several mechanisms. Firstly, direct viral-mediated cellular invasion of cardiomyocytes has been shown in in vitro and histological studies, which is related to cellular injury. Secondly, the proinflammatory state during COVID-19 can lead to myocardial injury and the release of protein remnants of the cardiac contractile machinery. Thirdly, the hypercoagulable state of COVID-19 is associated with thromboembolism of coronary arteries and/or other vascular systems. COVID-19 patients can also develop heart failure; however, the underlying mechanism is much less well-characterised than for myocardial injury. Several questions remain regarding COVID-19-related heart failure, including its potential reversibility, the role of anti-viral medications in its prevention, and the mechanisms underlying heart failure pathogenesis in long COVID-19. Further work is required to improve our understanding of the mechanism of cardiac sequelae in COVID-19, which may enable us to target SARS-CoV-2 and protect patients against longer-lasting cardiovascular complications.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- COVID-19 Pathophysiology: Inflammation to Cardiac Injury
- Date Crossref
- 13/12/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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West Middlesex University Hospital pays non établi dans la noticeÉtablissement de santé
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University of St Andrews pays non établi dans la noticeUniversité ou école supérieure
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University of London St George's pays non établi dans la noticeUniversité ou école supérieure
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Royal Sussex County Hospital Sussex Cardiac Centre pays non établi dans la noticeÉtablissement de santé
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University Hospitals Sussex NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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West Middlesex Hospital pays non établi dans la noticeÉtablissement de santé
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School of Medicine pays non établi dans la noticeUniversité ou école supérieure
West Middlesex University Hospital, University of St Andrews et St George's — University of London, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.