Saskia-Larissa Jauch-Speer

P01.15.A SINGLE NUCLEUS TRANSCRIPTOMICS OF SPINAL EPENDYMOMA TYPES AND SUBTYPES RECOGNIZES INTRATUMORAL HETEROGENEITY

Kalesha Hack, Saskia-Larissa Jauch-Speer, Catena Kresbach, Christian Thomas et autres

Abstract BACKGROUND The two most prevalent types of spinal ependymal tumors are myxopapillary ependymomas (MPE) and spinal ependymomas (SP-EPN). Based on molecular data from bulk tumor samples, we previously identified clinically relevant subtypes with poor (MPE-A; SP-EPN-A) and favorable progression-free survival (MPE-B; …

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Interleukin-27 Signaling Attenuates Renal Inflammation in Crescentic Glomerulonephritis

Vincent Piegsa, Tobias Neben, Nikhat Shaikh, Malte Hellmig et autres

Background: Glomerulonephritis (GN) is a heterogeneous group of immune-mediated disorders and is a frequent cause for end-stage renal disease. CD4+ T helper cells and particularly Th17 cells have been identified as major drivers of disease, and therapeutical blockade of pro-inflammatory cytokines is …

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Identification of Th17 Cells with Stemness Features in Crescentic Glomerulonephritis

Mingjie Lin, Nikhat Shaikh, Malte Hellmig, Arthur L. Hube et autres

Background: Th17 cells are key drivers of autoimmune diseases, but how they persist in renal autoimmunity remains unclear. The role of stem-like Th17 cells in this context has not been explored so far. Here, we explore Th17 cell heterogeneity, function and differentiation …

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Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh et autres

Rapidly progressive glomerulonephritis (RPGN) is the most aggressive group of autoimmune kidney diseases and is characterized by glomerular crescent formation with proliferation of parietal epithelial cells (PECs). However, the underlying mechanisms of glomerular crescent formation are incompletely understood. Here we provide a …

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Single-nucleus transcriptomics of spinal ependymoma subtypes recognizes intratumoral heterogeneity

Karoline Hack, Saskia-Larissa Jauch-Speer, Catena Kresbach, Melanie Schoof et autres

BACKGROUND: The 2 most prevalent types of spinal ependymal tumors are myxopapillary ependymomas (MPE) and spinal ependymomas (SP-EPN). Based on molecular data from bulk tumor samples, we previously identified clinically relevant subtypes with poor (MPE-A; SP-EPN-A) and favorable progression-free survival (MPE-B; SP-EPN-B). …

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Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice

Jonas Engeßer, Robin Khatri, Darius P. Schaub, Hans‐Joachim Paust et autres

In anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), glomerulonephritis is a severe kidney complication driven by immune cells, including T cells. However, the mechanisms underlying T cell activation in these contexts remain elusive. Here we report that in patients …

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PATH-21. SINGEL CELL TRANSCRIPTOMICS OF SPINAL EPENDYMOMA SUBTYPES IDENTIFIES INTRATUMORAL HETEROGENEITY

Karoline Hack, Saskia-Larissa Jauch-Speer, Ulrich Schüller

Abstract Spinal ependymomas comprise glial neoplasms that are classified by histological and molecular features. Two of the respective types, myxopapillary ependymomas (MPE) and spinal ependymomas (SP-EPN) are largely understudied. For each of these, our group identified clinically relevant subtypes with poorer (MPE-A; …

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Single-Cell Spatial Atlas of Immune and Kidney Cell States in Human Rapidly Progressive Glomerulonephritis

Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh et autres

Background: Rapidly progressive glomerulonephritis (RPGN) represents the most aggressive form of autoimmune kidney disease and is characterized by the formation of glomerular crescents and the infiltration of immune cells. However, a detailed definition of leukocyte composition, cellular localization and the interactions of …

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Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis

Jonas Engeßer, Robin Khatri, Darius P. Schaub, Yu Zhao et autres

Abstract Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (GN). To date, treatment of most patients with ANCA-GN relies on non-specific immunosuppressive agents, which may have serious adverse effects and …

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Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis

Katrin Brockhaus, Isabel Hemsen, Saskia-Larissa Jauch-Speer, Stephan Niland et autres

Introduction: Osteoclasts determine bone tissue turnover. Their increased activity causes osteoporosis, their dysfunction osteopetrosis. Methods and Results: Murine monocytic ER-Hoxb8 cells differentiate into OCs upon treatment with M-CSF and RANKL and upregulate the collagen-binding integrin α2β1 distinctly earlier than other OC markers, …

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STEM-03. A NOVEL MOUSE MODEL OF CHOROID PLEXUS CARCINOMA UNRAVELS SEQUENTIAL DEDIFFERENTIATION OF HINDBRAIN CHOROID PLEXUS TISSUE AND REVEALS NEW THERAPEUTIC PROSPECTS

Levke-Sophie Peter, Lea Altendorf, Karoline Hack, Vanessa Thaden et autres

Abstract BACKGROUND Choroid Plexus tumors constitute 10-20% of brain tumors in the first year of life. Among those, Choroid Plexus Carcinomas (CPC) pose a significant challenge due to their aggressiveness, resulting in poor survival rates and long-term adverse effects stemming from intense …

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Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis

Jonas Engeßer, Robin Khatri, Darius P. Schaub, Yu Zhao et autres

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