ABCA4-mutant human retinal organoids sequencing reveals organoids application in inherited retinal diseases
Yourong Bao, Jean Li, Zhen Zuo, Salma Ferdous et autres
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Yourong Bao, Jean Li, Zhen Zuo, Salma Ferdous et autres
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Yourong Bao, Jean Li, Zhen Zuo, Salma Ferdous et autres
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Shanu Markand, Somin Kim, Micah A. Chrenek, Salma Ferdous et autres
Purpose Myopia is a complex disorder with etiology involving an interplay between several genetic and environmental factors. Interphotoreceptor retinoid-binding protein (IRBP) is found in the subretinal space and is crucial in the visual cycle. The interphotoreceptor retinoid-binding protein knockout mouse (IRBP KO) …
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Zhen Zuo, Xuesen Cheng, Salma Ferdous, Jianming Shao et autres
The development of the retina is under tight temporal and spatial control. To gain insights into the molecular basis of this process, we generate a single-nuclei dual-omic atlas of the human developing retina with approximately 220,000 nuclei from 14 human embryos and …
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Debresha Shelton, Isabelle Gefke, Vivian Summers, Yong‐Kyu Kim et autres
Purpose: This study provides a systematic evaluation of age-related changes in RPE cell structure and function using a morphometric approach. We aim to better capture nuanced predictive changes in cell heterogeneity that reflect loss of RPE integrity during normal aging. Using C57BL6/J …
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Rui Chen, Zhen Zuo, Xuesen Cheng, Salma Ferdous et autres
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Jongsu Choi, Jin Li, Salma Ferdous, Qingnan Liang et autres
In this article, Jongsu Choi and Jin Li should have been denoted as equally contributing authors. The original article has been corrected.
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Jongsu Choi, Jin Li, Salma Ferdous, Qingnan Liang et autres
The visual signal processing in the retina requires the precise organization of diverse neuronal types working in concert. While single-cell omics studies have identified more than 120 different neuronal subtypes in the mouse retina, little is known about their spatial organization. Here, …
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Jiaxiong Lu, Renae Bertrand, Joseph J. Quinlan, Salma Ferdous et autres
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Jongsu Choi, Jin Li, Salma Ferdous, Qingnan Liang et autres
Abstract: The visual signal processing in the retina requires the precise organization of diverse neuronal types working in concert. While single-cell omics studies have identified more than 120 different neuronal subtypes in the mouse retina1, little is known about their spatial organization. …
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Jongsu Choi, Jin Li, Salma Ferdous, Qingnan Liang et autres
Abstract: The visual signal processing in the retina requires the precise organization of diverse neuronal types working in concert. While single-cell omics studies have identified more than 120 different neuronal subtypes in the mouse retina1, little is known about their spatial organization. …
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Salma Ferdous, Debresha Shelton, Tatiana E. Getz, Micah A. Chrenek et autres
Purpose The purpose of this study was to investigate the role of Lysine specific demethylase 1 (Lsd1) in murine retinal development. LSD1 is a histone demethylase that can demethylate mono- and di-methyl groups on H3K4 and H3K9. Using Chx10-Cre and Rho-iCre75 driver …
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