Rui Chen

Segmented poly(A) tails with microRNA target sites confer tissue-specific regulation for mRNA therapeutics

Rui Qian Qi, Rui Chen, Hua Chen, Hui Bao et autres

Abstract Targeted delivery and controlled expression of mRNA-LNPs are critical for the development of safe and effective mRNA medicines. However, efficient post-delivery regulation of mRNA-LNP expression remains challenging. In this study, we engineered segmented poly(A) tail variants that function as gene-specific regulatory …

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An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body

Jinjing Jian, Xuan Bao, Yi-Xiang Wang, Y Zheng et autres

Abstract The trabecular meshwork (TM) and ciliary body (CB) regulate aqueous humor dynamics and intraocular pressure (IOP), and TM/Schlemm’s canal (SC) dysfunction underlies glaucoma. Here, we present a spatially resolved multi-omics atlas of human TM and CB, integrating snRNA-seq, scRNA-seq, and snATAC-seq …

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Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma Pathophysiology

GULAB ZODE, Prakadeeswari Gopalakrishnan, Pei Tan, Sarahi Arguello et autres

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Bi-allelic variants in AP5Z1 and AP5B1 lead to retinal degeneration

Hafiz Muhammad Jafar Hussain, Meng Wang, Paul Yang, Behnoosh Tasharrofi et autres

Inherited retinal diseases (IRDs) comprise a diverse group of disorders that frequently lead to progressive vision impairment and blindness. Despite advances in genetic testing, a significant number of IRD cases remain genetically unsolved, often due to unidentified disease-associated genes or variants. This …

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Author Correction: Single-cell atlas of the transcriptome and chromatin accessibility in the human retina

Jin Li, Yi-Xiang Wang, Ignacio L. Ibarra, Xuesen Cheng et autres

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Single-cell atlas of the transcriptome and chromatin accessibility in the human retina

Jin Li, Jun Wang, Ignacio L. Ibarra, Xuesen Cheng et autres

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Retinol tracing within murine neural retina reveals cell type–specific retinol transport and distribution

Zachary J Engfer, Grażyna Palczewska, Samuel W. Du, Jianye Zhang et autres

11-cis-Retinal is essential for light perception in mammalian photoreceptors (PRs), and aberrations in retinoid transformations cause severe retinal diseases. Understanding these processes is crucial for combating blinding diseases. The visual cycle, operating within PRs and the retinal pigment epithelium (RPE), regenerates 11-cis-retinal …

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Rapamycin and Suramin Effects on TNF‐⍺‐Mediated Mast Cell and Brain Microvascular Endothelial Cell Dysfunction

Katherine A. Ebbert, Rui Chen, Robert A. Culibrk, Daniel J. Yeisley et autres

Chronic blood-brain barrier (BBB) disruption due to impaired function of brain microvascular endothelial cells (BMECs) is commonly observed in neuroinflammatory and neurodegenerative conditions. Current treatment approaches are generally limited in their capacity to reduce this dysfunction, with the Akt/mTOR/GSK pathway modulator rapamycin …

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SFC-GS: A Multi-Objective Optimization Service Function Chain Scheduling Algorithm Based on Matching Game

Shi Kuang, Sunan Wang, Haoran Li, Siyuan Liang et autres

Service Function Chain (SFC) is a framework that dynamically orchestrates Virtual Network Functions (VNFs) and is essential to enhancing resource scheduling efficiency. However, traditional scheduling methods face several limitations, such as low matching efficiency, suboptimal resource utilization, and limited global coordination capabilities. …

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#ECR-Paper-05 Genome-wide insights into the genes and pathways shaping human foveal development

Ha-Jun Yoon, Alvin Lirio, Kayesha Coley, Jun Wang et autres

Background Abnormal foveal pit formation is a hallmark of foveal hypoplasia (FH), a key feature of conditions such as albinism and PAX6-related aniridia. While rare, high-penetrance variants in these disorders are well described, the broader genetic architecture of foveal development, including contributions …

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Semi-Parametric Functional Kriging Regression Model with L1 Penalty

Rui Chen, Zhiyong Zhou

Partial functional linear models are widely studied and applied models, where the response variable is related to both general random variables and functional random variables. However, with the increasing application of data scenarios involving functional and vector-valued covariates and scalar responses in …

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Genome-Wide Insights Into the Genes and Pathways Shaping Human Foveal Development: Redefining the Genetic Landscape of Foveal Hypoplasia

Ha-Jun Yoon, Alvin Lirio, Kayesha Coley, Jun Wang et autres

Purpose: To define the genetic architecture of foveal morphology and explore its relevance to foveal hypoplasia (FH), a hallmark of developmental macular disorders. Methods: We applied deep-learning algorithms to quantify foveal pit depth from central optical coherence tomography (OCT) B-scans in 61,269 …

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