Bridging neurodevelopment and neurodegeneration in genetic frontotemporal dementia and Alzheimer's disease
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Le résumé fourni par la source
BACKGROUND: The current conceptualization of genetic frontotemporal dementia (FTD) and Alzheimer's disease (AD) is that they are neurodegenerative diseases characterized by symptoms that develop late in life. Yet, studies in animal models and humans support the notion that autosomal dominant genes, whose variants cause these diseases, also play critical roles in neurodevelopment. Some studies have identified subtle behavioral, cognitive and neuroanatomical characteristics in asymptomatic adult genetic variant carriers. It remains unknown, however, how early in life these differences emerge and to what extent children and young adults with these variants may exhibit clinical overlap with neurodevelopmental disorders such as autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and language-based learning disabilities (LBLD). METHODS: At the UCSF Dyslexia Center, children and young adults (age range 7 to 25) from families with an autosomal dominant genetic variant for FTD or AD, participants with ASD, ADHD, LBLD, and typically developing children (TDC)/young adult controls, are being recruited for assessment. Our recruitment goals over the five-year period include enrolling 50 participants from families with FTD, 50 participants from families with AD and 30 participants in each neurodevelopmental cohort. Measures collected include a neurological evaluation, neuropsychological testing, academic testing, and MRI brain scan (including T1, diffusion-weighted imaging, resting-state fMRI sequences). For participants from families with autosomal dominant FTD or AD, genetic testing for the variant in the family is performed on saliva specimens. Genetic variant status is not disclosed to participants or their families. RESULTS: To date, we have evaluated 40 participants from families with FTD, seven from families with AD, two with ASD, 15 with ADHD, 33 with LBLD, and 18 TDCs with recruitment ongoing. Planned comparisons will examine the effects of these genetic variants on neuropsychological profiles, academic test scores, brain volume, white matter tract integrity and resting-state functional connectivity networks. CONCLUSION: This study aims to characterize the neurodevelopmental phase of genetic FTD and AD, providing critical insights into their underlying biology and potential phenotypic overlap with neurodevelopmental syndromes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Bridging neurodevelopment and neurodegeneration in genetic frontotemporal dementia and Alzheimer's disease
- Date Crossref
- 01/12/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of California Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Palo Alto University pays non établi dans la noticeUniversité ou école supérieure
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Stanford University pays non établi dans la noticeUniversité ou école supérieure
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University of Oxford pays non établi dans la noticeUniversité ou école supérieure
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Georgia State University pays non établi dans la noticeUniversité ou école supérieure
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Georgia Department of Public Health pays non établi dans la noticeOrganisme public
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University of Southern California pays non établi dans la noticeUniversité ou école supérieure
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University Memory and Aging Center pays non établi dans la noticeUniversité ou école supérieure
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Keck School of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Neurology — University of California, Palo Alto University et Stanford University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.