Tim Beaumont

The Palimpsestuous intercultural afterlife of The Orphan of Zhao: ideological rewriting and the reactivation of theatrical musicality

Yuan Li, Tim Beaumont

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Is Mill a Liberal Nationalist?

Tim Beaumont, Yuan Li

Abstract Within nationality studies, the 19 th -century philosopher John Stuart Mill (1806–1873) is typically presented as the founding father of liberal-nationalism because of his warning that liberal democratic institutions need to be embedded within the framework of a mononational state. However, …

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A dynamic activation–memory cycle organizes the human IgG⁺ memory B cell compartment

Laura T. M. Graus, Andreas Chrysostomou, Denise Guerra, Gius Kerster et autres

Abstract B cells underpin durable immunity by generating long-lived memory B cells and antibody-secreting cells (ASCs) that re-engage upon antigen re-encounter. How human IgG⁺ memory B cells are organized to establish, maintain, and reactivate humoral immunity remains incompletely understood. Here, we combine …

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Innovative Single-Cell Sequencing Techniques for B cell Analysis and Their Implications for Rational HIV-1 Vaccine Design

Denise Guerra, Laura T. M. Graus, Tim Beaumont, Mathieu A. F. Claireaux et autres

Single-cell analysis to study the variety of immune cells has long been regarded as challenging. Recently, innovative techniques have emerged and have revolutionized the way immune cells can be explored, offering unprecedented insights into the dynamics of this complex system. In particular, …

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Plant‐produced SARS ‐ CoV ‐2 antibody engineered towards enhanced potency and in vivo efficacy

Steven W. de Taeye, Loic J-Y Faye, Bertrand Larrera de Morel, Angela I. Schriek et autres

Prevention of severe COVID-19 disease by SARS-CoV-2 in high-risk patients, such as immuno-compromised individuals, can be achieved by administration of antibody prophylaxis, but producing antibodies can be costly. Plant expression platforms allow substantial lower production costs compared to traditional bio-manufacturing platforms depending …

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Long-Lasting AML-Specific Antibody Responses after Allogeneic Hematopoietic Progenitor Cell Transplantation

Etsuko Yasuda, Nienke J.E. Haverkate, Hergen Spits, Tim Beaumont et autres

Background: Allogeneic hematopoietic progenitor cell transplantation (HCT) can cure patients with hematologic malignancies such as acute myeloid leukemia (AML) by inducing durable graft versus leukemia (GvL) immune responses. However, this procedure is often complicated by graft versus host disease and opportunistic infections. …

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Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses

Philip J. M. Brouwer, Hailee R. Perrett, Tim Beaumont, Haye Nijhuis et autres

Lassa fever continues to be a major public health burden in West Africa, yet effective therapies or vaccines are lacking. The isolation of protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the development of vaccines that can elicit strong …

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Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

Denise Guerra, Laura Radić, Mitch Brinkkemper, Meliawati Poniman et autres

Monoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize only a few sarbecovirus strains. Therefore, there is a growing interest in …

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Primary SARS-CoV-2 variant of concern infections elicit broad antibody Fc-mediated effector functions and memory B cell responses

Karlijn van der Straten, Denise Guerra, Gius Kerster, Mathieu A. F. Claireaux et autres

Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by human sera is a strong correlate of protection against symptomatic and severe Coronavirus Disease 2019 (COVID-19). The emergence of antigenically distinct SARS-CoV-2 variants of concern (VOCs) and the relatively rapid waning of …

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John Stuart Mill on the Suez Canal and the limits of self-defence

Tim Beaumont

Abstract Michael Walzer's use of John Stuart Mill's A Few Words on Non-Intervention (1859) helped to inaugurate it as a canonical text of international theory. However, Walzer's use of the text was highly selective because he viewed the first half as a …

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Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

Denise Guerra, Laura Radić, Mitch Brinkkemper, Meliawati Poniman et autres

Monoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize only a few sarbecovirus strains. Therefore, there is a growing interest in …

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A panel of hepatitis C virus glycoproteins for the characterization of antibody responses using antibodies with diverse recognition and neutralization patterns

Ana Chumbe, Marloes Grobben, Joan Capella-Pujol, Sylvie M. Koekkoek et autres

A vaccine against Hepatitis C virus (HCV) is urgently needed to limit the spread of HCV. The large antigenic diversity of the HCV glycoprotein E1E2 makes it difficult to design a vaccine but also to fully understand the antibody response after infection …

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