Hélène Gingras

On the role of choline in natural DNA transformation in Streptococcus pneumoniae

Flora Peillard-Fiorente, Chantal Godin, Hélène Gingras, Joanna Lecka et autres

Background Under laboratory conditions, DNA transformation of Streptococcus pneumoniae is facilitated by the addition of the Competence Stimulating Peptide (CSP). We recently showed that CSP can be dispensable for natural transformation but this depends on both the strains and the growth medium. …

fr (code pays fourni par la source)

Culturomics unveils species and expands bacterial and fungal diversity in Inuit oropharyngeal microbiota

Mathilde Flahaut, Philippe Leprohon, nguyen-phuong Pham, Hélène Gingras et autres

Abstract Recent advances in high-throughput sequencing and novel culture techniques have revolutionized our understanding of the human microbiota. However, most studies primarily focused on bacterial communities, often overlooking the fungal component. Building upon our previous metagenomic analysis of the Inuit oropharyngeal microbiome …

fr, ca (code pays fourni par la source)

Antimicrobial Activity of a Synthetic Brevibacillin Analog Against Multidrug-Resistant Campylobacter spp.

Khaled M. Abdallah, Omar Fliss, Nguyen-Phuong Pham, Louis-David Guay et autres

Campylobacter spp. is one of the most prevalent causes of zoonotic foodborne infections associated with diarrhea in humans. The growing threat of antibiotic resistance calls for innovative approaches. The antimicrobial lipopeptide brevibacillin produced by Brevibacillus laterosporus and its synthetic analog brevibacillin Thr1 …

Tunisie, ca (code pays fourni par la source)

Point mutations in functionally diverse genes are associated with increased natural DNA transformation in multidrug resistant Streptococcus pneumoniae

Flora Peillard-Fiorente, Nguyen-Phuong Pham, Hélène Gingras, Chantal Godin et autres

DNA transformation is key for phenotypic diversity and adaptation of Streptococcus pneumoniae including in the emergence of multidrug resistance (MDR). Under laboratory conditions, DNA transformation is facilitated by the artificial triggering of competence by the competence stimulating peptide (CSP). In ongoing DNA …

ca, cn, cz (code pays fourni par la source)

Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning

Nguyen-Phuong Pham, Hélène Gingras, Chantal Godin, Jie Feng et autres

ABSTRACT Antimicrobial resistance (AMR) is a public health threat worldwide. Next-generation sequencing (NGS) has opened unprecedented opportunities to accelerate AMR mechanism discovery and diagnostics. Here, we present an integrative approach to investigate trimethoprim (TMP) resistance in the key pathogen Streptococcus pneumoniae . …

ca, cn, fr (code pays fourni par la source)

Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 (Nrf1) in pancreatic β-cells

Fionnuala M. Morrish, Hélène Gingras, Joanna Noonan, Li Huang et autres

us, Afrique du Sud (code pays fourni par la source)

Distinctive features of the oropharyngeal microbiome in Inuit of Nunavik and correlations of mild to moderate bronchial obstruction with dysbiosis

Mathilde Flahaut, Philippe Leprohon, Nguyen-Phuong Pham, Hélène Gingras et autres

Inuit of Nunavik are coping with living conditions that can influence respiratory health. Our objective was to investigate associations between respiratory health in Inuit communities and their airway microbiome. Oropharyngeal samples were collected during the Qanuilirpitaa? 2017 Inuit Health Survey and subjected …

ca (code pays fourni par la source)

New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens

Hélène Gingras, Flora Peillard-Fiorente, Chantal Godin, Kévin Patron et autres

Two strains of Streptococcus pneumoniae , one expressing the methyltransferase Erm(B) and the other negative for erm (B), were selected for solithromycin resistance in vitro either with direct drug selection or with chemical mutagenesis followed by drug selection. We obtained a series …

ca (code pays fourni par la source)

Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 ( Nrf1 ) in pancreatic β-cells

Fionnuala M. Morrish, Hélène Gingras, Joanna Noonan, Li Huang et autres

SUMMARY Genetic polymorphisms in nuclear respiratory factor-1 ( NRF1 ), a key transcriptional regulator of nuclear-encoded mitochondrial proteins, have been linked to diabetes. Homozygous deletion of Nrf1 is embryonic lethal in mice. Our goal was to generate mice with β-cell-specific reduction in …

us (code pays fourni par la source)

Mitochondrial Diabetes in Mice Expressing a Dominant-Negative Allele of Nuclear Respiratory Factor-1 ( Nrf1) in Pancreatic β-Cells

Fionnuala M. Morrish, Hélène Gingras, Joanna Noonan, Li Huang et autres

Afrique du Sud, us (code pays fourni par la source)

Corrigendum: Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli

Hélène Gingras, Bédis Dridi, Philippe Leprohon, Marc Ouellette

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks …

ca (code pays fourni par la source)

Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis

Christelle Morelle, Angana Mukherjee, Jiabao Zhang, Fereshteh Fani et autres

Chemotherapy against the neglected tropical disease visceral leishmaniasis (VL) is suboptimal with only four licensed drugs. Amphotericin B (AmB), despite its toxicity, remained a second line drug for a long time. However, the demonstration that liposomal AmB is highly effective against VL …

ca, us (code pays fourni par la source)