Tiancong Zhao

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu et autres

ABSTRACT Catheter‐related bloodstream infection (CRBSI) is an important clinical problem that causes significant mortality and excess economic cost. Recent epidemiological trends indicate a shift in CRBSI pathogens from Gram‐positive to Gram‐negative bacilli, among which Pseudomonas aeruginosa , Klebsiella pneumoniae , and Acinetobacter …

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Molecular-interfacial-electronic triple design for enhanced cooperative adsorption and SERS detection of perfluorooctanoic acid

Fanglei Liu, Yang Jin, 白洪海, Yufang Kou et autres

Abstract Perfluorooctanoic acid (PFOA), the most environmentally ubiquitous representative of per- and polyfluoroalkyl substances (PFAS), has posed global environmental and health risks due to its persistence. To address the challenges of insufficient adsorption, low intrinsic Raman activity and poor specific recognition of …

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AI‐Optimized 3D‐Printed Dual‐Layer Implant: Resolving Chemo‐Immunotherapy Sequential Administration Dilemma for Colorectal Cancer Peritoneal Metastasis

W T Tang, Bing Liu, Ye Liu, Shuai Wang et autres

The synergistic integration of chemotherapy and immunotherapy represents the most promising strategy for enhancing therapeutic efficacy in cancer treatment. Chemotherapy initiates the therapeutic cascade by inducing immunogenic cell death (ICD), thereby releasing tumor antigens and prime immune sensitization. Subsequently, immunotherapy blocks immune …

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Mechanochemically Coupled Multidimensional Modulation of Calcium Overload

Yating Zhan, Hao Xing, Minchao Liu, Yufang Kou et autres

Disruption of calcium ion (Ca 2+ ) homeostasis has emerged as a promising strategy for tumor therapy. However, the intricate regulation of Ca 2+ signaling and the limitations of single-dimensional modulation often hinder therapeutic efficacy. Here, we developed a Janus nanomotor platform …

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An inflammation-modulating ferroptotic nanoplatform for immune-compatible cancer therapy

Qing Chen, Shanyou Tong, Minchao Liu, Yating Zhan et autres

Chronic tumor-associated inflammation can impair dendritic-cell (DC) antigen presentation and limit immune engagement, posing a barrier to ferroptosis-based therapeutic strategies that often intensify oxidative stress. Here we develop an inflammation-compatible ferroptosis-inducing therapeutic platform by co-integrating an NF-κB-modulating small molecule, celastrol, with an …

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Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Junfeng Song, Yang Song, Xirui Huang, Xingjin Li et autres

Chronic diabetic foot infections are severely hindered by tough biofilms and a self-fueling hyperinflammatory microenvironment, primarily orchestrated by the synergistic interplay between extracellular DNA (eDNA) and lipopolysaccharides (LPS) which facilitates the assembly of impenetrable biofilm architectures while inducing cross-inflammatory activation through the …

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Antimicrobial/Anti-Inflammatory Peptidomimetic-Polyphenol Co-Assemblies with pH-Triggered Activation for S. aureus Abscess Therapy

Junfeng Song, Anming Yang, Yang Song, X S Huang et autres

The treatment of Staphylococcus aureus subcutaneous abscesses is hindered by the protective abscess microenvironment and persistent bacterial colonization. Herein, we present a pH-responsive supramolecular nanoplatform fabricated via single-step coassembly of cationic arginine-derived antimicrobial peptidomimetics ( AMPM -1) and natural polyphenols. This process, …

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Medicinal and Edible Plants: Naturally Nano-Ready Medicine

Jifeng Wang, Yu Zhao, Tiancong Zhao

Abstract For millennia, “medicine–food homology” has identified numerous plants possessing both nutritional and therapeutic value. Modern research reveals that these medicinal and edible plants (MEPs) harbor bioactive constituents with an innate capacity for nanoscale self-organization, enabled by structural features such as π-conjugated …

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Synthesis of Hollow Polyaniline Nanospheres via Surface Tension‐Guided Double Emulsion System for Zn Carriers in Aqueous Batteries

Jie Zhang, Gaoyang Li, Jiahao Chen, Xingjin Li et autres

ABSTRACT Hollow mesoporous architectures present new opportunities for electrode design, yet conventional syntheses remain hampered by tedious hard‐template or unstable soft‐templates. Herein, a surface tension‐guided double‐emulsion template strategy is reported for the one‐step synthesis of uniform hollow polyaniline (PANI) nanospheres. Distinct from …

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Correction to “Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence”

Kun Zhang, Yuhan Lin, Ling Dong, Yuting Niu et autres

sponsorship: Fudan University|25TQ011, National Natural Science Foundation of China|82574236, Fudan University|21TQ1400100, National Natural Science Foundation of China|82304297, National Key Research and Development Program of China|2025YFE0205700, Shanghai Pujiang Programme|23PJD005

Trimodule Synergistic Janus Mesoporous Nanomotor for Photothermally-Enhanced Chemodynamic Therapy

Yanming Ma, Jia Jia, Yating Zhan, Minchao Liu et autres

Chemodynamic therapy (CDT) holds great promise for specific tumor ablation by in situ catalyzing endogenous H 2 O 2 into highly reactive ·OH radicals that induce oxidative stress and trigger cell apoptosis. However, the intrinsically low H 2 O 2 level in …

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Designing metal-organic frameworks (MOFs) for advanced per- and polyfluoroalkyl substances (PFAS) management: Adsorption, detection, and degradation

Jun Cheng, Yahui Guo, Weirong Yao, He Qian et autres

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