Marawan A. Elbaset

Design, Synthesis, and Molecular Docking of Benzimidazole Derivatives as Angiotensin II AT1‐Receptor Antagonists in a Hypertensive Rat Models

Alaadin E. Sarhan, Hanaa S. Mohamed, Mohamed F. Abdelhameed, Ahmed M. Nagy et autres

High blood pressure is a major risk factor of cardiovascular disorders. Experimental models of hypertension play a critical role in elucidating its pathophysiological mechanisms and in evaluating novel therapeutic agents. In this study, a series of benzimidazole-based derivatives (I- XIIIa-d) were designed …

Égypte, us (code pays fourni par la source)

Ziziphus spina-christi leaves mitigates oxidative stress-provoked pulmonary dysfunction via targeting TGF-β1/NOX-4/p-Smad 3 signalling and in-silico validation

Marwa M. Elbatanony, Marawan A. Elbaset, Marwa E. Shabana, Ahmed F. El-Sayed et autres

Protective Role of Linagliptin in Cisplatin‐Mediated Liver Injury: Involvement of STAT3 and AMPK/SIRT1/PGC‐1alpha Mitochondrial Energy Sensing Networks

Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Yosra A Hussien et autres

Cisplatin (Cis), a commonly used chemotherapy drug, is associated with liver toxicity, which restricts its broader clinical use. This study investigated the potential protective effects of linagliptin (Lina), a DPP-4 inhibitor, in preventing liver damage induced by Cis in rats. There were …

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Apigenin: a Promising Therapeutic Agent for Combating Obesity and Metabolic Dysfunction in Obese Rats

Marawan A. Elbaset, Hany Moawad Fayed, Samir A. E. Bashandy, Osama A. El‐Shabrawy et autres

HIGHLIGHTS Induction of obesity in rats was done using a high-fat diet (HFD) and tap water containing 25% sucrose for a duration of 16 weeks. Obese control group exhibited significant increases in body weight, body mass index, waist circumference, dyslipidemia. Increase in …

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Unveiling phytoconstituents and the anti-inflammatory potential of Crassula tetragona L. in ulcerative colitis: A focus on the PPARγ/SIRT1 axis

Mona A. Raslan, Rehab F. Abdel‐Rahman, Hany M. Fayed, Marawan A. Elbaset et autres

Crassula species are traditionally used and possess anti-inflammatory properties, but Crassula tetragona L. remains largely unexplored. This study intended to characterize C. tetragona aerial parts' phytoconstituents and assess its anti-ulcerative potential via the PPARγ/SIRT1 pathway. Aerial parts of C. tetragona were extracted …

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Linagliptin attenuates kidney cancer in rats via AMPK activation and suppression of YAP/TAZ/HIF-1α signaling

Tahani Saeedi, Mohannad A. Almikhlafi, Hossein M. Elbadawy, Muayad Albadrani et autres

This study investigated the renoprotective action of linagliptin compared to doxorubicin against thioacetamide (TAA) and diethyl nitrosamine (DEN)-induced renocarcinogenesis in a rat model. Male Wistar rats were divided into control, renocarcinogenesis (RCC), doxorubicin group (7.5 mg/kg, i.p., once weekly), and linagliptin (Lina) …

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Dielectric Spectroscopy as a Novel Diagnostic and Therapeutic Monitoring Tool in Apigenin-Mediated Reversal of Obesity-Associated Hepatic Dysfunction

Sherif A. Abdelmottaleb Moussa, Samir W. Aziz, Rehab F. Abdel‐Rahman, Marawan A. Elbaset et autres

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Evaluation of the collagen enhancing capability of a novel cosmeceutical hesperidin methyl chalcone nano-formulation: A preclinical appraisal in rats

Riham I. El-Gogary, Hend Abd-Allah, Rania F. Ahmed, Marawan A. Elbaset et autres

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Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation

Rehab F. Abdel‐Rahman, Mahdi H. Alsugoor, Naif Alsuhaymi, Hany M. Fayed et autres

A novel class of antidiabetic drugs known as sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) prevents the renal proximal tubules from reabsorbing glucose. While a recent study showed that SGLT2-Is may be able to slow the proliferation of cancer cells that express SGLT2, limited …

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Short-term effects of sertraline against depressive-like behaviors in a rat model of neonatal hypoxic encephalopathy

Marie-Michèle Serghani, Sondos Kassem-Moussa, Rawan Makki, Abdallah Kurdi et autres

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Cilostazol ameliorates Cisplatin-induced nephrotoxicity via modulation of PI3K/AKT/mTOR signaling pathway and autophagy in rats

Salma A. El‐Marasy, Nesma M E Abo El-Nasr, Dina E. ElMosbah, Marawan A. Elbaset

This study aimed to evaluate the nephroprotective effect of Cilostazol on Cisplatin-induced nephrotoxicity. Female Wistar albino rats were divided into four groups: normal, Cis (8 mg/kg), and two Cilostazol treatment groups (30 and 60 mg/kg) with cisplatin. Cisplatin application significantly deteriorated renal …

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Design, Synthesis, Biological Evaluation, and Computational Studies of Novel 1,4‐Diketopiperazines as GABA Agonist

Mostafa Abd El‐Mohsen Anwar, Eman R. Mohammed, Samir M. El Moghazy, Nesma M.E. Abo El- Nasr et autres

A novel series of 1,1-disubstituted cyclohexane 7a-e, 8a-e, and 9a-e were designed, synthesized, and evaluated for their anticonvulsant activities. Compounds 7c, 8c, 8d, and 9a displayed significant anticonvulsant activity in both maximum electroshock seizure (MES) and pentylenetetrazol (PTZ) induced seizure during the …

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