Mohamed F. Abdelhameed

Design, Synthesis, and Molecular Docking of Benzimidazole Derivatives as Angiotensin II AT1‐Receptor Antagonists in a Hypertensive Rat Models

Alaadin E. Sarhan, Hanaa S. Mohamed, Mohamed F. Abdelhameed, Ahmed M. Nagy et autres

High blood pressure is a major risk factor of cardiovascular disorders. Experimental models of hypertension play a critical role in elucidating its pathophysiological mechanisms and in evaluating novel therapeutic agents. In this study, a series of benzimidazole-based derivatives (I- XIIIa-d) were designed …

Égypte, us (code pays fourni par la source)

Phytochemical Constituents and Biological Activities of Brachychiton Genus: A Comprehensive Review

Aya A. Wafaey, Seham S. El Hawary, Farid N. Kirollos, Mohamed A. El-Raey et autres

Integrated metabolomics and network pharmacology reveal multi-target phytotherapeutic activities of Frankenia hirsuta against inflammation and diabetic neuropathy with cytotoxic potential

amaal helmy zokalih, Seham El Hawary, Abeer M. El Sayed, Mohamed A. El Raey et autres

OBJECTIVES: Frankenia hirsuta (FH) is an underexplored halophytic plant used for managing inflammatory and metabolic disorders. However, its phytochemical composition and pharmacological mechanisms remain largely uncharacterized. Thus, this study aimed to comprehensively elucidate the phytochemical profile, molecular mechanisms, and pharmacological efficacy of …

Égypte (code pays fourni par la source)

Topical cream loaded with upcycled citrus bioactive chitosan-pectin nanoparticle protects skin from UV-induced photoaging

Faten M. Ibrahim, Mohamed F. Abdelhameed, Eman Samy Shalaby, Nermin A. Ragab et autres

Égypte, pt, vn (code pays fourni par la source)

Novel Repurposing of Empagliflozin-Loaded Buccal Composite (Chitosan/Silk Fibroin/Poly(lactic acid)) Nanofibers for Alzheimer’s Disease Management via Modulation of Aβ–AGER–p-tau Pathway

Walaa A. El‐Dakroury, Samar A. Salim, Abdelrahman R. Said, Gihan F. Asaad et autres

Background/Objectives: Empagliflozin (EMPA) was repurposed for Alzheimer’s disease (AD) treatment via buccal delivery, exploiting novel nanofibers (NFs) integrating chitosan (Cs), silk fibroin (Fb), and poly(lactic acid) (PLA). Methods: EMPA-loaded Cs/Fb/PLA NFs were electrospun in different formulations to optimize the formulation parameters. The …

Égypte (code pays fourni par la source)

Integrative network pharmacology and experimental validation of rubus ulmifolius leaf extract in a rat model of MRSA-infected wounds

Essam M Alharshani, Seham S. El‐Hawary, Mohamed F. Abdelhameed, Shaymaa A. Ismail et autres

Égypte, sa (code pays fourni par la source)

Bioactive-rich Mangifera indica leaf extracts alleviate inflammation, pain, and fever via suppression of pro-inflammatory cytokines and activation of Nrf2 pathways

Mai M. Elghonemy, Amira R. Khattab, Mohamed F. Abdelhameed, Alaa M. Ali et autres

Égypte, de, jp (code pays fourni par la source)

Enhanced Wound Healing, Anti-Inflammatory, and Anti-Oxidative Effects of Vitamin C-Loaded Hyaluronic Acid–Collagen Scaffolds in Preclinical Rat Models

A. Salem, Samah El‐Ghlban, Ahmed S. Montaser, Mohamed F. Abdelhameed et autres

Wound healing is a complex biological process critical for restoring skin integrity after injury. However, chronic wounds present significant clinical challenges due to persistent inflammation, oxidative stress, disrupted collagen synthesis, and susceptibility to infection. Bioactive scaffolds have emerged as promising therapeutic strategies …

by, Égypte, us (code pays fourni par la source)

Phyto-Mediated Zinc Oxide Nanoparticles from Raphanus sativus (L.): Metabolomic Insights, Gastroprotective Potential, and Docking-Supported Evidence

doaa kamel Alsayed, Seham S. El‐Hawary, Mohamed A. El Raey, Gihan Fouad et autres

(L.) root extract and evaluate their gastroprotective effect against ethanol-induced gastric injury in rats. ZnO-NPs were characterized through UV-Vis spectroscopy, FT-IR, TEM, zeta potential analysis, and XRD. LC- MS-coupled metabolic profiling was employed to identify different phytochemical compounds in the plant. Oxidative …

Égypte, sa (code pays fourni par la source)

UHPLC-QTOF-MS/MS metabolomic profiling and in silico-in vivo evaluation of Gliricidia sepium leaves for renoprotection in diabetic nephropathy

Aya A Wafaey, Seham S. El‐Hawary, Mohamed A. El Raey, Sahar S. Abdelrahman et autres

Égypte, gb (code pays fourni par la source)

High‐Integrity Nanoformulation of Resiquimod (R848) for Dual Autophagy Activation and PD‐L1 Modulation in Triple‐Negative Breast Cancer

Ahmed F. Salem, Sara Aly Attia, Samah El‐Ghlban, Ahmed S. Montaser et autres

Triple-negative breast cancer (TNBC) remains a formidable clinical challenge due to its molecular heterogeneity and resistance to conventional therapies. This study presents a high-integrity nanoemulsion (NE) formulation designed to enhance the delivery and stability of the Toll-like receptor 7/8 (TLR7/8) agonist resiquimod …

Égypte, us (code pays fourni par la source)

Chrysin matodextrin cationized guar complex nanoparticles modulates lung aging induced by D-galactose in mice: Forkhead box proteins impact in cell longevity and apoptosis

Abeer Salama, Eman Samy Shalaby, Noha N. Yassen, Mohamed F. Abdelhameed

Égypte (code pays fourni par la source)