Shanzhong Tan

Icariin Mitigated Non-Alcoholic Fatty Liver Disease Progression via miR-185-3P/CX3CL1 Axis

Wenwen Hong, Ruomei Zhang, Shanzhong Tan

Non-alcoholic fatty liver disease (NAFLD) ranks among the most prevalent liver diseases globally. Icariin (ICA) has been shown to improve NAFLD, but the specific molecular mechanisms remain unclear. The study was to probe the underlying mechanisms of ICA in NAFLD. Quantitative real-time …

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Yi-Qi-Jian-Pi formula alleviates hepatic fibrosis in acute-on-chronic liver failure by regulating ferritinophagy-mediated hepatic stellate cell senescence

Jing Chen, Xiangxiang Tang, Sijia Hu, Juan Wang et autres

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Atractylodin Enhances the Efficacy of Fluconazole Against Fluconazole-Resistant C. albicans by Promoting ROS Accumulation and Synergizes with Fluconazole Against C. albicans Biofilm

Jinyun Song, Juan Wang, Sijia Hu, Jinghan Gao et autres

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Huangjia Ruangan granules with entecavir for fibrosis regression in Chroinc Hepatitis B: A multicenter, randomized, double-blind, phase II trial

Xiaojun Zhu, Jinghao Zhang, Zhijia Zhou, Suthat Liangpunsakul et autres

BACKGROUND: Huangjia Ruangan Granules (HRG) has shown promising therapeutic effects in treating hepatic fibrosis in China. This study aimed to assess its specific efficacy. METHODS: This 48-week phase II study was a multicenter, randomized, double-blind, placebo-controlled trial conducted at 14 centers in …

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Magnolol mitigates morphine-induced analgesic tolerance via EGFR-mediated inhibition of microglial activation and neuroinflammatory reduction

Weixin Lin, Yuxuan Wang, Qisheng Wang, Jiamin Moran Huang et autres

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Expanding insights on immune cells and insomnia: A Mendelian randomization study using updated data

Xu Zhang, Shasha Zhang, Shanzhong Tan, Lizhong Guo

Insomnia is a prevalent sleep disorder associated with cognitive impairments, mood disturbances, and increased risks of cardiovascular and psychiatric conditions. Emerging evidence suggests that immune dysregulation contributes significantly to insomnia pathogenesis; however, the causal roles of specific immune cell phenotypes remain unclear. …

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Corrigendum to “pPB peptide-modified nanostructured lipid carriers loaded with astragaloside IV as a potential strategy for enhanced antifibrosis therapy” [Int. J. Biol. Macromol. 319 (2025) 145221]

Shasha Zhang, Xu Zhang, Min Wang, Lizhong Guo et autres

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pPB peptide-modified nanostructured lipid carriers loaded with astragaloside IV as a potential strategy for enhanced antifibrosis therapy

Shasha Zhang, Xu Zhang, Min Wang, Lizhong Guo et autres

Activated hepatic stellate cells (HSCs) are central to hepatic fibrosis pathogenesis, driving excessive extracellular matrix deposition and pathological angiogenesis. Despite their therapeutic potential, conventional antifibrotic agents face challenges in selectively targeting HSCs, limiting efficacy and increasing off-target toxicity. Here, we address this …

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Salidroside attenuates the acquisition of morphine‐induced conditioned place preference in mice via improving neurosynaptic plasticity in the ventral tegmental area

Zhonghao Li, Xinru Mu, Qisheng Wang, Ziting Zhou et autres

BACKGROUND AND PURPOSE: Rhodiola rosea has therapeutic effects in several neurological disease models and its ethanolic extract prevents the acquisition of morphine-induced conditioned place preference (CPP). We investigate the potential mechanism by which the active component of R. rosea attenuates the acquisition …

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Integrative systems biology in insomnia: Bridging traditional Chinese medicine and modern science

Xu Zhang, Shasha Zhang, Shanzhong Tan

This article is interested in the applications and technological innovations of systems biology to insomnia research within an integrative framework of Traditional Chinese Medicine (TCM) and modern science. Insomnia, a common sleep disorder, is a significant global health threat and has emerged …

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Chinese herbal decoction, Yi-Qi-Jian-Pi formula exerts anti-hepatic fibrosis effects in mouse models of CCl4-induced liver fibrosis

Shiyan Yang, Yajun Cheng, Xiaolong Wang, Suyang Yue et autres

Background: Yi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that is used to treat patients with liver failure. However, scientific evidence supporting the treatment of hepatic fibrosis with YQJPF has not been forthcoming. The present study aimed to determine the mechanisms underlying the …

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Yi-Qi-Jian-Pi formula inhibits hepatocyte pyroptosis through the IDH2-driven tricarboxylic acid cycle to reduce liver injury in acute-on-chronic liver failure

Rong Zhao, Qiang Zhao, Xi Wang, Xiaomei Chen et autres

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