2026
preprint
OpenAlex
Pratik Shriwas, Abigail M. Noonchester, Brian T. Scarpitti, Andre Revnew et autres
Abstract Of the cytochrome P450 enzymes, CYP3A4 is the most abundant isoform in the human liver, and this enzyme plays a dominant role in the metabolism of a wide range of clinical drugs and xenobiotics. Previous studies have demonstrated that CYP3A4 participates …
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2026
article
OpenAlex
Sanjun Fan, Ran Cheng, Haonan Lin, Zhewen Luo et autres
Surface-enhanced coherent anti-Stokes Raman scattering (SECARS) is believed to increase the signal intensity and sensitivity by combining the localized surface plasmon resonance and coherent Raman enhancement. However, the realization of SECARS is more complex than for surface-enhanced Raman scattering (SERS) and remains …
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2025
article
OpenAlex
Sanjun Fan, Brian T. Scarpitti, Abigail E. Smith, Zhewen Luo et autres
A facile and novel method to synthesize core/satellite (CS) nanoparticles via a linker-free method is reported. Au spheres on the tips of nanostars can gradually grow bigger and eventually transform into gap-enhanced Raman tags (GERTs) to form stable and ultrabright Au nanostar/GERTs …
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2024
article
OpenAlex
Sanjun Fan, Brian T. Scarpitti, Zhewen Luo, Abigail E. Smith et autres
Hot spot engineering in plasmonic nanostructures plays a significant role in surface enhanced Raman scattering for bioanalysis and cell imaging. However, creating stable, reproducible, and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes …
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2023
article
OpenAlex
Brian T. Scarpitti, Sanjun Fan, Madeleine Lomax-Vogt, Anthony Lutton et autres
Understanding the uptake, distribution, and stability of gold nanoparticles (NPs) in cells is of fundamental importance in nanoparticle sensors and therapeutic development. Single nanoparticle imaging with surface-enhanced Raman spectroscopy (SERS) measurements in cells is complicated by aggregation-dependent SERS signals, particle inhomogeneity, and …
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2022
article
OpenAlex
Deben Shoup, Brian T. Scarpitti, Zachary D. Schultz
High spatial resolution imaging and chemical-specific detection in living organisms is important in a wide range of fields from medicine to catalysis. In this work, we characterize a wide-field surface-enhanced Raman scattering (SERS) imaging approach capable of simultaneously capturing images and SERS …
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2022
article
OpenAlex
Brian T. Scarpitti, Chureeporn Chitchumroonchokchai, Steven K. Clinton, Zachary D. Schultz
The ability to monitor the uptake and distribution of food nutrients in in vitro cell culture models is key to understanding the efficacy of these nutraceuticals to treat and prevent disease. Lycopene is a carotenoid found in chloroplasts and chromoplasts of tomatoes, …
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2022
article
OpenAlex
Courtney J. Morder, Brian T. Scarpitti, Karin M. Balss, Zachary D. Schultz
Lentiviruses are commonly used to deliver genetic code into host cells for biomedical applications, such as gene therapy, pharmaceuticals, and vaccine development. Knowing the infectious titer of these virus particles is critical for development in these areas. Current methods of determining viral …
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2021
article
OpenAlex
Carlos Diego L. de Albuquerque, Chelsea M. Zoltowski, Brian T. Scarpitti, Deben Shoup et autres
High Resolution Image Download MS PowerPoint Slide Challenges investigating molecules on plasmonic nanostructures have limited understanding of these interactions. However, the chemically specific information in the surface-enhanced Raman scattering (SERS) spectrum can identify perturbations in the adsorbed molecules to provide insight relevant …
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2020
article
OpenAlex
Brian T. Scarpitti, Amy M. Morrison, Marina Buyanova, Zachary D. Schultz
Measurements of cellular pH are used to infer information such as stage of cell cycle, presence of cancer and other diseases, as well as delivery or effect of a therapeutic drug. Surface-enhanced Raman spectroscopy (SERS) of nanoparticle-based pH probes have been used …
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2019
article
OpenAlex
Sian Sloan‐Dennison, MaKenzie R. Bevins, Brian T. Scarpitti, Victoria K. Sauvé et autres
Chemical signals are conveyed to cells through ligand-receptor binding, triggering cascades of biochemical reactions and resulting in pivotal cellular functions. These binding events are important in understanding membrane signaling and drug interactions. To probe ligand-receptor binding, surface enhanced Raman scattering (SERS) tags …
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