Michael Goddard

The Impacts of Knowledge Management and Information Technology Advances on Public Health Decision-Making in 2010

Michael Goddard, David L. Mowat, Christopher Corbett, Cordell Neudorf et autres

Population and public health programs in Canada in local/regional, provincial/ territorial and federal governments have been working together to adopt and to adapt modern information and communication technologies (ICTs) to improve program effectiveness. Effective public health is information intensive and the impact …

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Two stage model for carcinogenesis: number and size distributions of premalignant clones in longitudinal studies

Anjana Dewanji, Michael Goddard, Daniel Krewski, Suresh H. Moolgavkar

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Evolving Statistical Issues in Carcinogenicity Studies

Michael Goddard

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Empirical and Biologically Based Models for Cancer Risk Assessment

Jan M. Zielinski, Daniel Krewski, Michael Goddard, Y. Wang

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The future of mechanistic research in risk assessment: Where are we going and can we get there from here?

Michael Goddard, Daniel Krewski

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A 60-Hz magnetic field increases the incidence of squamous cell carcinomas in mice previously exposed to chemical carcinogens

J. R. N. McLean, A. Thansandote, D. W. Lecuyer, Michael Goddard et autres

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Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures

Robert L. Lipnick, Joseph A. Cotruvo, Richard N. Hill, R. Douglas Bruce et autres

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Temporal Aspects of Risk Characterization

Michael Goddard, D. Murdoch, Daniel Krewski

Although many laboratory studies are conducted with the dose level held constant for the duration of the experimental period, human exposure to toxic substances can vary widely over time. In this article we discuss methods for toxicologic risk assessment with time-dependent exposure …

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Case-Control Study of Residential Radon and Lung Cancer in Winnipeg, Manitoba, Canada

E.G. Létourneau, Daniel Krewski, N. W. Choi, Michael Goddard et autres

A case-control study of lung cancer in relation to exposure to radon in homes in Winnipeg, Manitoba, Canada, was conducted during 1983-1990. In total, 738 individuals with histologically confirmed incident cases of lung cancer were interviewed, along with 738 controls matched on …

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A Weibull Model for the Estimation of Tumorigenic Potency

Anjana Dewanji, Daniel Krewski, Michael Goddard

In this paper, a new method of estimating tumorigenic potency is proposed that takes into account information on survival and, when available, the underlying cause of death. Specifically, Weibull distributions are used to describe the time to tumor occurrence (X), the time …

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Modification of tumor promotion in the mouse skin by exposure to an alternating magnetic field

M.A. Stuchly, J. R. N. McLean, Richard T. Burnett, Michael Goddard et autres

ca (code pays fourni par la source)

Interspecies Extrapolation of Toxicity Data1

Michael Goddard, Daniel Krewski

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