Zhaowenbin Zhang

Fe-MOF@Quercetin complex with light-controlled redox modulation for tumor wound repair

Yuze Xu, Lan Chang, Zhaowenbin Zhang, Jiang Chang

After the excision of tumor such as melanoma, the wound site often suffers from tumor recurrence and poor healing. A major clinical dilemma associated with photodynamic therapy is that the tumor excision site requires high reactive oxygen species (ROS) to inhibit tumor …

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Hybrid manufacturing of carbon fiber reinforced thermoplastic composites: Synergistic strategies and performance breakthroughs

Chen Qin, Qiwei Wu, Shengde Huang, Meiyin Xin et autres

Carbon fiber reinforced thermoplastic composites (CFRTP) have gained immense interest across multiple industrial sectors owing to their high specific strength, recyclability, and potential for rapid processing. However, standalone manufacturing processes are frequently hindered by intrinsic limitations. While additive manufacturing (AM) affords high …

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Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction

Yiming Zhong, Zhaowenbin Zhang, Shixing Huang, Ao Shen et autres

Myocardial infarction (MI) can induce an imbalance in the trace element ion microenvironment within the human body. This study preliminarily explored the changing patterns of zinc (Zn) and copper (Cu) ions after MI, revealing the dynamic changes of these two ions in …

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Doping-Engineered Pro-Angiogenic Nanozymes Orchestrate Ischemic Tissue Regeneration via Cytoprotection and Revascularization

Hongxia Li, Xiaosheng Sheng, Chuandong Qiu, Dongmin Chen et autres

Effective therapy for ischemic diseases requires not only timely restoration of perfusion but also protection of ischemic tissues from secondary insults, particularly oxidative-stress-induced injury. Here, we propose the concept of "proangiogenic nanozymes" and develop an efficient screening platform by doping angiogenic elements …

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Osteogenic Nanozymes for Diabetic Bone Regeneration via Synergistic Antioxidant and Osteoinductive Functions

Zhaoxu Meng, Zhen Zeng, Zhaowenbin Zhang, Lefeng Su et autres

Bone regeneration under diabetic conditions remains a formidable challenge, predominantly due to persistent oxidative stress, chronic inflammation, and impaired osteogenic potential of stem cells. Nanozymes have been widely employed to modulate oxidative stress and inflammation, and are considered promising candidates for diabetic …

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A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

Chen Yang, C Q Dong, Lefeng Su, Zhiqiang Liu et autres

Under metabolic disorders such as diabetes, the regenerative capacity of bone tissue is compromised, characterized by hyperglycemia-induced oxidative stress, impaired osteogenesis, and dysregulated angiogenesis. These complications undermine the efficacy of conventional bone repair materials, limiting their capacity to promote effective healing. Herein, …

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Silicified strontium-curcumin chelated nanospheres mitigate inflammatory vicious cycles to accelerate diabetic wound healing

Zhiwei Zhao, Youjun Ding, Guangbin Gao, Yepeng Zhang et autres

In diabetic wounds, the overexpression of reactive oxygen species (ROS) and the imbalance of the immune microenvironment surrounding immune cells, such as macrophages, can trigger a vicious cycle of inflammation in the wound area, a key factor contributing to impaired wound healing. …

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Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long‐Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells (Adv. Sci. 38/2025)

Qiangfei Su, Jian Wang, Yu Song, Zhaowenbin Zhang et autres

Bioactive Silk Sericin In article number 2507241, Zheng Wang, Jiang Chang, Lin Wang, and co-workers develop a novel artificial nerve guidance conduit that integrates silk sericin and bioceramics for long-gap peripheral nerve repair. This work highlights the synergistic effect of silk sericin …

Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long‐Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells

Qiangfei Su, Jian Wang, Yu Song, Zhaowenbin Zhang et autres

Schwann cells are pivotal in generating a pro-regenerative microenvironment for long-gap peripheral nerve injury (PNI) repair via their orchestrated behaviors, including cell migration, proliferation, and secretion. Bioceramics can release bioactive ions to regulate "repair" cells for regenerating damaged tissues. Herein, bioceramic akermanite …

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Extracellular vesicles derived from silicate‐stimulated antler reserve mesenchymal cells alleviate kidney damage in diabetic nephropathy through inhibiting abnormal angiogenesis and apoptosis

Pengfei Hu, Zhaowenbin Zhang, Dongxu Wang, Xiuying Li et autres

Abstract Extracellular vesicles (EVs) facilitate the intercellular transfer of bioactive macromolecules and are capable of traversing physiological barriers and demonstrate considerable promise as innovative cell‐free therapies for treating a variety of diseases. Here, we showed a novel approach to use silicate ions …

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Therapeutic silicate biomaterials for sarcopenia treatment by inhibiting inflammation and enhancing muscle regeneration through regulation of Sarcolipin/SIRT signaling pathway

Zhaowenbin Zhang, Lan Chang, Hanjiao Chen, Long Ren et autres

Based on the observation of silicon content decrease in the muscles and serum with aging, this study proposes a silicate bioactive material based therapy for treating sarcopenia. Two therapeutic strategies were designed. One utilizes calcium silicate (CS) hydrogel for localized intramuscular treatment, …

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3D-printed titanium dioxide-reinforced calcium silicate composite scaffold promotes efficient bone defect repair through activation of osteogenic and angiogenic differentiation

Zhiqiang Huang, Xinyi Wang, Zhaowenbin Zhang, Bin Yu et autres

Addressing the challenges of insufficient mechanical strength, high fragility, and rapid degradation in calcium silicate (CS) 3D-printed bone regeneration scaffolds and acknowledging the necessity to enhance performance of CS in bone and vascular regeneration, this study innovatively presents a titanium dioxide (TiO …

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