Caroline Tigoi

Multiomics characterization of acute child illness and mortality in Africa and South Asia

Camilo A. Espinosa, James M. Njunge, Kirkby Daniel Tickell, Abdoulaye Hama Diallo et autres

Childhood illnesses from infectious diseases in low- and middle-income countries contribute substantially to the global under-five mortality. Many hospitalized children experience incomplete recovery, readmission, and post-discharge mortality despite guideline-directed care. However, targeted interventions remain elusive due to limited understanding of underlying mechanisms. …

us, Kenya, Burkina Faso, bd, pk, gb, no, ca, Malawi, nl, cn, Ouganda, kh (code pays fourni par la source)

Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design

Yan Shao, Shuyi Wang, Bonface M. Gichuki, Mark D. Stares et autres

Bifidobacterium longum and B. infantis are pioneer colonizers of the neonatal gut and are widely used as probiotics to support infant growth, development, and disease resistance. However, commercial strains derived largely from high-income countries (HICs) may be suboptimal for infants in low- …

gb, Kenya, bd, Burkina Faso (code pays fourni par la source)

Patterns of Dysglycemia Identified by Continuous Glucose Monitoring among Critically Ill Children in Malawi and Bangladesh

Philliness P Harawa, Celine Bourdon, Farnaz Khoshnevisan, Shafiqul A Sarker et autres

Abstract Dysglycemia is a critical metabolic disturbance associated with mortality in acutely ill children, yet its burden may be underrecognized in low-income settings due to reliance on single point-of-care measurements. Using continuous glucose monitoring (CGM), we aimed to characterize glucose patterns in …

Malawi, Kenya, ca, bd, gb, us, nl (code pays fourni par la source)

ALARUM: Active One Health surveillance in LMICs to monitor and predict Antimicrobial Resistance Using Metagenomics – a cross-sectional study protocol

Marianne A. B. van der Sande, Daniel Valia, Caroline Tigoi, Nicole Stoesser et autres

Background In rural sub-Saharan Africa (sSA), the burden of antimicrobial resistance (AMR) remains high. As AMR continues to rise, there is a strong need for practical, implementable surveillance to monitor and mitigate risks, as well as inform timely, evidence-based clinical decision-making. Emerging …

nl, us, Burkina Faso, Kenya, gb, ch, be, de (code pays fourni par la source)

Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage

Thomas D. Stanton, Shaun P Keegan, Jabir A. Abdulahi, Anne V. Amulele et autres

BACKGROUND: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against ≥70% of K. pneumoniae infections, could avert ~400,000 cases and ~80,000 deaths annually, mostly in Africa and South Asia. Vaccine formulations …

au, gb, Kenya, bd, us, in, pk, Afrique du Sud, Zambie, Tanzanie, Botswana, Malawi, Nigéria, Rwanda, it, Éthiopie, dk, ie, Ghana (code pays fourni par la source)

Pancreatic Enzymes and/or Bile Acids for Acutely Ill Severely Malnourished Children – a Double-Blind Randomized Placebo-Controlled Trial

Robert Bandsma, Mohammod Jobayer Chisti, Wieger P. Voskuijl, Moses Mukaba Ngari et autres

ca, Kenya, bd, nl, Ouganda, kh, Malawi, us (code pays fourni par la source)

Pancreatic enzymes and/or bile acids for acutely ill severely malnourished children – a double-blind randomized placebo-controlled trial

Robert Bandsma, Mohammod Jobayer Chisti, Wieger P. Voskuijl, Moses Mukaba Ngari et autres

Abstract Background Translocation of bacteria across the intestinal barrier has been postulated to contribute to mortality among severely malnourished children. Pancreatic enzymes (PE) and bile acids (BA) have anti-bacterial properties in the small intestine, but severe malnutrition is associated with impaired exocrine …

ca, Kenya, bd, nl, Ouganda, Malawi, Afrique du Sud, us, gb, cn (code pays fourni par la source)

Multiomics characterization of acute child illness and mortality in Africa and South Asia

Camilo Espinosa Bernal, James Mwaura Njunge, Kirkby Daniel Tickell, Abdoulaye Hama Diallo et autres

Childhood illnesses from infectious diseases in low- and middle-income countries contribute substantially to the global under-five mortality. Many hospitalised children experience incomplete recovery, readmission, and post-discharge mortality despite guideline-directed care. However, targeted interventions remain elusive due to a limited understanding of underlying …

us, Kenya, Nigéria, bd, pk, gb, no, ca, kh, Malawi, nl, cn, Ouganda (code pays fourni par la source)

Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia

James M. Njunge, Evans O. Mudibo, Jasper Bogaert, Benedict Orindi et autres

In resource-limited settings, children often experience poor growth following illness, but the mechanisms are poorly understood. This cohort study in six countries in sub-Saharan Africa and south Asia investigates pathways linking inflammation and post-discharge weight gain among children hospitalised with acute illness. …

Kenya, gb, nl, be, ca, Ouganda, us, Malawi, Burkina Faso, bd, pk (code pays fourni par la source)

Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries

Christopher Allen, Arya Ghate, James M. Njunge, Lisa Gartner et autres

Childhood mortality remains high in low-resource settings, where environmental enteric dysfunction (EED) is prevalent. Peripheral blood bacterial lipopolysaccharides (LPS) are potential biomarkers of intestinal microbial translocation and inflammation; however, the effects of LPS translocation on mortality in this context remains unexplored. We …

gb, Kenya, Burkina Faso, us, Ouganda, Malawi, ca, nl, bd, pk (code pays fourni par la source)

Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: analysis of infection clusters inferred from pathogen genomics and temporal data

Erkison Ewomazino Odih, Anne V Amulele, Matthew Bates, Eva Heinz et autres

Abstract Background Klebsiella pneumoniae is the leading cause of sepsis among neonates in low- and middle-income countries (LMICs) in Africa and Asia, contributing substantially to the overall burden of antimicrobial resistant (AMR) infections and mortality among neonates globally. Pathogen sequencing has been …

gb, Kenya, us, in, Afrique du Sud, Zambie, Tanzanie, Botswana, Malawi, au, Nigéria, Rwanda, it, Éthiopie, dk, pk, ie, Ghana (code pays fourni par la source)

Genomic epidemiology of Klebsiella pneumoniae neonatal and infant sepsis in Kenyan hospitals

Anne V Amulele, Benedict Orindi, Moreka L Ndumba, Caroline Tigoi et autres

Abstract Background Klebsiella pneumoniae ( Kpn ) is a leading cause of sepsis among hospitalised neonates and commonly causes outbreaks. Lack of surveillance data from low- and middle-income countries hampers development of vaccines and new measures to control infections. We describe the …

Kenya, gb (code pays fourni par la source)