Patterns of Dysglycemia Identified by Continuous Glucose Monitoring among Critically Ill Children in Malawi and Bangladesh
Rattachement africain : Malawi, Kenya, ca, bd, gb, us, nl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Dysglycemia is a critical metabolic disturbance associated with mortality in acutely ill children, yet its burden may be underrecognized in low-income settings due to reliance on single point-of-care measurements. Using continuous glucose monitoring (CGM), we aimed to characterize glucose patterns in acutely ill children of different anthropometric status. Methods Children aged 2-23 months admitted with acute illness were prospectively recruited from two hospitals in Bangladesh and Malawi. Clinical data were collected, and interstitial glucose was monitored for 48 hours using the Dexcom G4 Platinum system. Glucose excursions and variability were analyzed and associated with anthropometric status. Results Of 93 enrolled children, 88 had sufficient CGM data: 21 not wasted (NW), 22 moderately wasted (MW), and 45 with severe malnutrition (SAM; 29 severe wasting [SW], 16 edematous malnutrition [EM]). Low-glucose excursions were detected in 8 (38%) children with NW, 11 (50%) with MW, 12 (41%) with SW, and 10 (63%) with EM. While not confirmed hypoglycemia, these low-glucose excursions were longer and more frequently below severe thresholds in children with EM. Hyperglycemic excursions occurred in 31% of children and were longer in children with SAM compared to NW (median 41 vs. 23 min, p<0.0001). Overall, 35% of children maintained euglycemic profiles, while others exhibited marked glucose variability. Conclusion CGM revealed frequent glucose instability among acutely ill children, with patterns varying across anthropometric groups. When interpreted cautiously, CGM may serve as a research tool to detect dysglycemia and assess response to therapeutic or nutritional interventions in critically ill children in low-resource settings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Patterns of Dysglycemia Identified by Continuous Glucose Monitoring among Critically Ill Children in Malawi and Bangladesh
- Date Crossref
- 01/02/2026
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kamuzu Central Hospital Malawi (code pays fourni par la source)Établissement de santé
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The Childhood Acute Illness and Nutrition Network Kenya (code pays fourni par la source)Institution
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Kamuzu University of Health Sciences Department of Paediatrics and Child Health Blantyre, Malawi (code pays fourni par la source)Université ou école supérieure
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Hospital for Sick Children Translational Medicine Program pays non établi dans la noticeÉtablissement de santé
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University of Toronto pays non établi dans la noticeUniversité ou école supérieure
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International Centre for Diarrhoeal Disease Research pays non établi dans la noticeStructure de recherche
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Kenya Medical Research Institute Kenya (code pays fourni par la source)Structure de recherche
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KEMRI-Wellcome Trust Research Programme Kenya (code pays fourni par la source)Structure de recherche
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University of Oxford Centre for Tropical Medicine and Global Health pays non établi dans la noticeUniversité ou école supérieure
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University of Liverpool pays non établi dans la noticeUniversité ou école supérieure
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Malawi-Liverpool-Wellcome Trust Clinical Research Programme Malawi (code pays fourni par la source)Structure de recherche
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Johns Hopkins University Departments of International Health pays non établi dans la noticeUniversité ou école supérieure
Kamuzu Central Hospital (Malawi), The Childhood Acute Illness and Nutrition Network (Kenya) et Department of Paediatrics and Child Health — Kamuzu University of Health Sciences (Blantyre, Malawi), avec 9 autres affiliations. Pays d’affiliation : Malawi, Kenya.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.