Alaaeldin Shablak

Comparison of survival between liver-only metastasis and other metastatic sites in patients with de novo stage 4 gastric cancer: Nationwide data from a single institute.

Alaaeldin Shablak, Lubna A. Zar, Ahmed M. Abdalhadi, Mohamed Serr et autres

e16044 Background: Although recent studies have shown a steady decline in the incidence and mortality over the past several decades, Gastric cancer (GC) remains the fourth major cause of cancer related mortality. Stage 4 GC is an advanced stage of disease, as …

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173P Gastric adenocarcinoma: Does the location matter? A retrospective study from a single oncology center

Ahmed M. Abdalhadi, M. Sir Elkhatim, S. Abdelrahim, Nabil Elhadi Omar et autres

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Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review

Ahmed M. Abdalhadi, Mouhammad J Alawad, Nabil Elhadi Omar, Muhammed Hajmusa et autres

Ramucirumab is an anti-angiogenic drug that received Food and Drug Administration (FDA)-approvals for treatments of many cancers. Gastrointestinal fistulas and perforations are recognized side effects of anti-angiogenic therapies, however, there are very few reported cases of these conditions in patients managed with …

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Gemcitabine-based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score-matched cohort study

Alma L. Moekotte, Giuseppe Malleo, Stijn van Roessel, Morgan Bonds et autres

BACKGROUND: Whether patients who undergo resection of ampullary adenocarcinoma have a survival benefit from adjuvant chemotherapy is currently unknown. The aim of this study was to compare survival between patients with and without adjuvant chemotherapy after resection of ampullary adenocarcinoma in a …

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Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma: International multicenter cohort study

Alma L. Moekotte, Sanne Lof, Stijn van Roessel, Michele Fontana et autres

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Histopathologic Predictors of Survival and Recurrence in Resected Ampullary Adenocarcinoma

Alma L. Moekotte, Sanne Lof, Stijn van Roessel, Martina Fontana et autres

OBJECTIVE: The aim of the study was to define histopathologic characteristics that independently predict overall survival (OS) and disease-free survival (DFS), in patients who underwent resection of an ampullary adenocarcinoma with curative intent. SUMMARY BACKGROUND DATA: A broad range of survival rates …

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High-dose interleukin2 – a 10-year single-site experience in the treatment of metastatic renal cell carcinoma: careful selection of patients gives an excellent outcome

Shien Chow, Victoria Galvis, Manon Rhys Pillai, Robin J. Leach et autres

Background VEGF-targeted therapy has become the mainstay of treatment for majority of mRCC patients. For most patients, benefit is short-lived and therefore treatment remains palliative in intent. HD IL2 is an effective immunotherapy treatment capable of durable remission in some patients but …

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High dose Interleukin 2 (HD IL2) as 1st line treatment in metastatic renal cell carcinoma (mRCC): A 10-year single centre experience.

Shien Chow, Victoria Galvis, Manon Rhys Pillai, R. H. Leach et autres

4555 Background: Targeted therapy has become the treatment of choice for majority of mRCC cases in recently. For most, treatment benefit is short-lived and given with palliative intent. HD IL2 is an effective treatment capable of durable remission but its unselected use …

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Evaluating the Place of Interleukin-2 in the Management of Metastatic Renal Cell Cancer (MRCC) in the Era of Targeted Therapy

Manon Evans, Shien Chow, Victoria Galvis, Robin J. Leach et autres

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High-Dose Interleukin-2 (Hd Il2) Armed with Pathology-Based Selection Criteria: a Real Option in Treatment of Metastatic Renal Cell Carcinoma (Mrcc) After Targeted Therapy

Shien Chow, Victoria Galvis, Manon Evans, Kitty Chan et autres

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In vitroeffect of IL-2 in combination with pazopanib or sunitinib on lymphocytes function and apoptosis of RCC cells

Alaaeldin Shablak, David Edward Gilham, Robert E. Hawkins, Eyad Elkord

OBJECTIVE: Combination of immunotherapy with tyrosine kinase inhibitors (TKIs) has been used with some success for the treatment of metastatic renal cell carcinoma. Herein we evaluate the in vitro effect of high-dose interleukin-2 (HDIL-2) and pazopanib or sunitinib on the lymphocyte function …

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A case of fatal cetuximab-induced interstitial lung disease during the first weeks of treatment

Alaaeldin Shablak, Andrew Conn

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