Panagiotis Kavvadas

Targeted Cx43 deletion in podocytes or endothelial cells protects against experimental glomerulonephritis

Stefanny M. Figueroa, Panagiotis Kavvadas, Ahmed Yaseen Abed, Jessica Madaoui et autres

fr (code pays fourni par la source)

Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury

Magali Genest, Satoshi Kinugasa, Elena Roger, Louis Boutin et autres

BACKGROUND: We have previously reported that the gap junction protein connexin 43 (Cx43) was upregulated in chronic renal disease in humans and rodents and plays a crucial role in the progression of experimental nephropathy. In this study, we investigated its role after …

fr (code pays fourni par la source)

Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis

Lilia Abbad, Maximin Détrait, Panagiotis Kavvadas, Dorian Bergonnier et autres

fr (code pays fourni par la source)

EPAC1-Mediated cAMP Signaling Promotes Cellular Energy Adaptations and Glycolytic Metabolic Shift in Podocytes to Protect from Glomerulonephritis

Lilia Abbad, Maximin Détrait, Panagiotis Kavvadas, Lisa Melis et autres

Background: Many efforts are made to identify new therapeutic targets to slow down, prevent Chronic Kidney Disease (CKD) progression. One of the therapeutic approaches is activating the renoprotective cAMP pathway. The exchange factor directly activated by cAMP 1 (EPAC1) has been identified …

fr (code pays fourni par la source)

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury

Elena Roger, Christos Evangelos Chadjichristos, Panagiotis Kavvadas, Gareth William Price et autres

Abstract Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types. Activated in response to danger associated molecular patterns (DAMPs) …

fr, gb (code pays fourni par la source)

#4904 EPAC1- MEDIATED CAMP SIGNALLING PROMOTES CELLULAR ENERGY ADAPTATIONS IN PODOCYTES TO PROTECT FROM GLOMERULONEPHRITIS

Lilia Abbad, Maximin Détrait, Panagiotis Kavvadas, Lisa Melis et autres

Abstract Background and Aims Many efforts are made to identify new therapeutic targets to slow down, prevent or even reverse Chronic Kidney Disease (CKD) progression. One of the therapeutic approaches is activating the renoprotective cAMP pathway, especially by stimulation of its downstream …

fr (code pays fourni par la source)

Down‐regulation of human long non‐coding RNA LINC01187 is associated with nephropathies

Theodora Manolakou, Valeria Kaltezioti, Niki Prakoura, Panagiotis Kavvadas et autres

Chronic kidney diseases affect a substantial percentage of the adult population worldwide. This observation emphasizes the need for novel insights into the molecular mechanisms that control the onset and progression of renal diseases. Recent advances in genomics have uncovered a previously unanticipated …

gr, fr, de (code pays fourni par la source)

Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca2+ Entry

Frank Helle, Michael Hultström, Panagiotis Kavvadas, Bjarne M. Iversen et autres

Notch3 plays an important role in the differentiation and development of vascular smooth muscle cells. Mice lacking Notch3 show deficient renal autoregulation. The aim of the study was to investigate the mechanisms involved in the Notch3-mediated control of renal vascular response. To …

fr, se, no (code pays fourni par la source)

Notch3 expression in capillary pericytes predicts worse graft outcome in human renal grafts with antibody‐mediated rejection

Yi-Chun Xu-Dubois, Panagiotis Kavvadas, Zela Keuylian, Alexandre Hertig et autres

Microvasculature consisting of endothelial cells and pericytes is the main site of injury during antibody-mediated rejection (ABMR) of renal grafts. Little is known about the mechanisms of activation of pericytes in this pathology. We have found recently that activation of Notch3, a …

fr (code pays fourni par la source)

Activation of Notch3 in Renal Tubular Cells Leads to Progressive Cystic Kidney Disease

Sonja Djudjaj, Panagiotis Kavvadas, Niki Prakoura, Roman David Bülow et autres

BACKGROUND: Polycystic kidney disease (PKD) is a genetic disorder affecting millions of people worldwide that is characterized by fluid-filled cysts and leads to end-stage renal disease (ESRD). The hallmarks of PKD are proliferation and dedifferentiation of tubular epithelial cells, cellular processes known …

de, fr (code pays fourni par la source)

EPAC1-Mediated cAMP Signaling in Podocytes Protects Kidneys from the Progression of Glomerulonephritis

Lilia Abbad, Panagiotis Kavvadas, Maximin Détrait, Niki Prakoura et autres

Background: Many efforts are made to identify new therapeutic targets to slow down, prevent or even reverse Chronic Kidney Disease (CKD) progression. One of the therapeutic approaches is the targeting of the renoprotective cAMP pathway, especially by stimulation of its downstream effector, …

fr (code pays fourni par la source)

Super‐resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement

Florian Tesch, Florian Siegerist, Eleonora Hay, Nadine Artelt et autres

Under healthy conditions, foot processes of neighbouring podocytes are interdigitating and connected by an electron-dense slit diaphragm. Besides slit diaphragm proteins, typical adherens junction proteins are also found to be expressed at this cell-cell junction. It is therefore considered as a highly …

de, it, fr (code pays fourni par la source)