Carlos K Virgous

Intermittent Fasting Attenuates Obesity-Induced Triple-Negative Breast Cancer Progression by Disrupting Cell Cycle, Epithelial–Mesenchymal Transition, Immune Contexture, and Proinflammatory Signature

Deok‐Soo Son, Kaitlyn A. Done, Jubin Son, Michael G. Izban et autres

Obesity is associated with one-fifth of cancer deaths, and breast cancer is one of the obesity-related cancers. Triple-negative breast cancer (TNBC) lacks estrogen and progesterone receptors and human epidermal growth factor receptor 2, leading to the absence of these therapeutic targets, followed …

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Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment

Carlos K Virgous, Letitia Lyons, Amos M. Sakwe, Tultul Nayyar et autres

Hydroxyurea (HU), a drug for treating cancers of the blood and the management of sickle cell anemia, induces hypogonadism in males. However, the impact of HU on testicular architecture and function, as well as its effects on the resumption of male fertility …

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How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice?

Longyun Zhang, Carlos K Virgous, Hongwei Si

Ginsenoside Rh2, an intermediate metabolite of ginseng, but not naturally occurring, has recently drawn attention because of its anticancer effect. However, it is not clear if and how Rh2 inhibits preadipocytes differentiation. In the present study, we hypothesized that ginsenoside Rh2 attenuates …

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Combination of curcumin and luteolin synergistically inhibits TNF-α-induced vascular inflammation in human vascular cells and mice

Lijuan Zhang, Xiaoyong Wang, Longyun Zhang, Carlos K Virgous et autres

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Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals

Lijuan Zhang, Carlos K Virgous, Hongwei Si

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Implication of calcium activated RasGRF2 in Annexin A6-mediated breast tumor cell growth and motility

Diva S. Whalen, Sarrah E. Widatalla, Olga Y. Korolkova, Gladys S. Nangami et autres

// Diva S. Whalen 1, * , Sarrah E. Widatalla 1, * , Olga Y. Korolkova 1 , Gladys S. Nangami 1 , Heather K. Beasley 1 , Stephen D. Williams 1 , Carlos Virgous 2 , Brian D. Lehmann 3 , …

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Ginseng and obesity: observations and understanding in cultured cells, animals and humans

Longyun Zhang, Carlos K Virgous, Hongwei Si

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High corn oil dietary intake improves health and longevity of aging mice

Hongwei Si, Longyun Zhang, Siqin Liu, Tanya LeRoith et autres

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Elevated Hepatic Hexose-6-Phosphate Dehydrogenase and Glucose-6-Phosphate Transporter Expression May Contribute to the Development of Diabetic Syndrome in Diabetic Mice.

Yanjun Liu, Ying Wang, Yuichi Nakagawa, Wei Qiang Wang et autres

Activated charcoal and the absorption of ferrous sulfate in rats.

Naomi M. Gades, Peter A. Chyka, Adrianne Y. Butler, Carlos K Virgous et autres

The treatment of iron poisoning has typically not included the administration of activated charcoal due to the lack of evidence supporting its efficacy. Several in vitro studies have demonstrated good adsorption of iron in a variety of pH ranges that were comparable …

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Chronic restraint via tail immobilization of mice: effects on corticosterone levels and other physiologic indices of stress.

Tiffani D. Rogers, Naomi M. Gades, Jeffrey D Kearby, Carlos K Virgous et autres

Chronic venous cannulation in mice is an acceptable and useful technique for repeated blood sampling or continuous intravenous administration of substances, for which mild restraint of the animal may be necessary. Because chronic restraint has drawn considerable attention in the animal welfare …

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