Thomas S. Klitzner

Preventing respiratory illness in cerebral palsy: Results of a pilot randomized controlled trial

Ryan J. Coller, Kristina Devi Singh‐Verdeflor, Jens C. Eickhoff, Paul J. Chung et autres

BACKGROUND: Respiratory illness is consistently the leading cause of death and hospitalization in severe cerebral palsy (CP). Respiratory Exacerbations-Plan for Action and Care Transitions (RE-PACT) is a just-in-time adaptive intervention to prevent respiratory illness in severe CP. RE-PACT combines early illness detection …

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Adaptive Intervention to Prevent Respiratory Illness in Cerebral Palsy: Protocol for a Feasibility Pilot Randomized Controlled Trial

Alyssa Fleischman, Carlos F. Lerner, Heidi M. Kloster, Paul J. Chung et autres

BACKGROUND: This study will pilot-test an innovative just-in-time adaptive intervention to reduce severe respiratory illness among children with severe cerebral palsy (CP). Our intervention program, Respiratory Exacerbation-Plans for Action and Care Transitions (RE-PACT), delivers timely customized action planning and rapid clinical response …

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Barriers to and facilitators of a just-in-time adaptive intervention for respiratory illness in cerebral palsy: a qualitative study

Kristina Devi Singh‐Verdeflor, Heidi M. Kloster, Carlos F. Lerner, Thomas S. Klitzner et autres

OBJECTIVE: To understand caregiver, healthcare professional and national expert perspectives on implementation of a just-in-time adaptive intervention, RE-PACT (Respiratory Exacerbation-Plans for Action and Care Transitions) to prevent respiratory crises in severe cerebral palsy. DESIGN: Qualitative research study. SETTING: Paediatric complex care programmes …

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Adaptive Intervention to Prevent Respiratory Illness in Cerebral Palsy: Protocol for a Feasibility Pilot Randomized Controlled Trial (Preprint)

Alyssa Fleischman, Carlos F. Lerner, Heidi M. Kloster, Paul J. Chung et autres

BACKGROUND This study will pilot-test an innovative just-in-time adaptive intervention to reduce severe respiratory illness among children with severe cerebral palsy (CP). Our intervention program, Respiratory Exacerbation–Plans for Action and Care Transitions (RE-PACT), delivers timely customized action planning and rapid clinical response …

Caregiving and Confidence to Avoid Hospitalization for Children with Medical Complexity

Ryan J. Coller, Carlos F. Lerner, Paul J. Chung, Thomas S. Klitzner et autres

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Linking Parent Confidence and Hospitalization through Mobile Health: A Multisite Pilot Study

Ryan J. Coller, Carlos F. Lerner, Jay G. Berry, Thomas S. Klitzner et autres

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Key Population Health Outcomes for Children with Medical Complexity: A Systematic Review

Elizabeth S. Barnert, Ryan J. Coller, Bergen Ballard Nelson, Lindsey R. Thompson et autres

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Excitation-Contraction Coupling in Neonatal Myocardium: Effects of Halothane and Isoflurane

Victor C. Baum, Thomas S. Klitzner

We evaluated the effects of halothane and isoflurane on force, action potential, and staircase, an indicator of sarcoplasmic reticulum function, in right ventricular papillary muscles from 4- to 8-day rabbits using a single sucrose gap myograph at a low baseline stimulating frequency …

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Health-Related Quality of Life in Children and Young Adults with Marfan Syndrome

Jill Handisides, Danielle Hollenbeck-Pringle, Karen C. Uzark, Felicia L. Trachtenberg et autres

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A Healthy Life for a Child With Medical Complexity: 10 Domains for Conceptualizing Health

Elizabeth S. Barnert, Ryan J. Coller, Bergen Ballard Nelson, Lindsey R. Thompson et autres

BACKGROUND AND OBJECTIVES: Defining and measuring health for children with medical complexity (CMC) is poorly understood. We engaged a diverse national sample of stakeholder experts to generate and then synthesize a comprehensive list of health outcomes for CMC. METHODS: = 125) first …

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Complex Care Hospital Use and Postdischarge Coaching: A Randomized Controlled Trial

Ryan J. Coller, Thomas S. Klitzner, Carlos F. Lerner, Bergen Ballard Nelson et autres

OBJECTIVES: We sought to examine the effect of a caregiver coaching intervention, Plans for Action and Care Transitions (PACT), on hospital use among children with medical complexity (CMC) within a complex care medical home at an urban tertiary medical center. METHODS: PACT …

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Acute Effects of Amiodarone on Sodium Currents in Isolated Neonatal Ventricular Myocytes: Comparison with Procainamide

F Chen, Glenn T. Wetzel, Thomas S. Klitzner

Recent studies suggest that amiodarone's acute clinical effects in infants and children are related predominantly to its class I antiarrhythmic activity. However, the effects of amiodarone on Na+ currents have not been investigated directly in immature cardiac cells. Accordingly, the tight seal …

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