Kristina D. Rinker

Cost-effectiveness of Biennial Breast Screening in Women With Dense Breasts: Exploratory Analysis of Pathways Incorporating an Emerging Blood RNA Test

Jacie T. Cooper, Alan Hollingsworth, Randy D. Moore, Cheryl Croft et autres

BACKGROUND: Emerging blood-based tests have potential to complement current breast imaging to increase early-stage detection for women with dense breasts. This analysis examines the cost-effectiveness of potential pathways using preliminary data from an emerging blood test to inform future research. MATERIALS AND …

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Abstract 3520: New role for CDK6 activation in tumor-induced monocyte and platelet reprogramming in breast cancer

Karen Norek, Jacob Kennard, Kenneth Fu, Robert D. Shepherd et autres

Abstract Background: Tumor-derived signals can reprogram immune cells and platelets to support cancer progression. However, the regulatory mechanisms underlying this systemic education are not well understood. Methods: RNA sequencing was performed on isolated platelet and white blood cell fractions from breast cancer …

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Tumor–Immune Cell Crosstalk Drives Immune Cell Reprogramming Towards a Pro-Tumor Proliferative State Involving STAT3 Activation

Karen Norek, Jacob Kennard, Kenneth F. Fuh, Robert D. Shepherd et autres

Background/Objectives: Tumor-induced immune reprogramming is increasingly recognized as a key mechanism by which cancers evade surveillance and promote disease progression. The interaction between cancer and immune cells within the tumor microenvironment (TME) can drive phenotypic and functional changes in immune populations, facilitating …

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Blood vessel wall shear stress determines regions of liposome accumulation in angiogenic vasculature

Marta Gómez-Garcı́a, Mahmoud Abdelkarim, David T. Cramb, Sarah J. Childs et autres

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Blood Vessel Wall Shear Stress Determines Regions of Liposome Accumulation in Angiogenic Vasculature

Marta Gómez-Garcı́a, Mahmoud Abdelkarim, David T. Cramb, Sarah J. Childs et autres

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Status of breast cancer detection in young women and potential of liquid biopsy

Maya Stibbards-Lyle, Julia Malinovska, Seleem Badawy, Pepper S. Schedin et autres

Young onset breast cancer (YOBC) is an increasing demographic with unique biology, limited screening, and poor outcomes. Further, women with postpartum breast cancers (PPBCs), cancers occurring up to 10 years after childbirth, have worse outcomes than other young breast cancer patients matched …

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Abstract PO4-24-05: Fluid forces and hormone levels during mammary gland development drive changes in breast epithelium that are relevant to the progression of postpartum breast cancer

Maya Stibbards-Lyle, Kristina D. Rinker, Laura Marie Hall, Seleem Badawy et autres

Abstract Postpartum breast cancer (PPBC), diagnosed in the 5-10 years after childbirth, has an elevated risk of metastasis and death. Poor outcomes are thought to be due to factors involved in mammary gland involution, an important stage of mammary gland development. Involution …

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Abstract PO5-25-02: Microenvironment based co-culture dependence of breast cancer and immune cell interactions on functional outcomes

Karen Norek, Jacob Kennard, Kenneth F. Fuh, Robert K. Shepherd et autres

Abstract The tumour microenvironment (TME) includes physical forces from interstitial fluid flow and cell-cell interactions that modulate cancer development and progression through activation of multiple oncogenic pathways leading to tumor growth and metastatic spreading. We previously reported on the role of physical …

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Abstract 5567: Breast cancer cell alteration of immune cell transcriptome through indirect communication

Jacob Kennard, Karen Norek, Kenneth F. Fuh, Robert D. Shepherd et autres

Abstract Crosstalk between tumor and non-tumor cells plays an important role in cancer progression and metastasis often leading to a modification of non-malignant cells into pro-oncogenic phenotypes. Understanding this process is important for diagnostic and therapeutic advances. We previously reported clinical validation …

Vessel Metrics: A software tool for automated analysis of vascular structure in confocal imaging

Sean D. McGarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong et autres

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rasa1 -related arteriovenous malformation is driven by aberrant venous signalling

Jasper Greysson-Wong, Rachael Rode, Jae‐Ryeon Ryu, Jo Li Chan et autres

Arteriovenous malformations (AVMs) develop where abnormal endothelial signalling allows direct connections between arteries and veins. Mutations in RASA1, a Ras GTPase activating protein, lead to AVMs in humans and, as we show, in zebrafish rasa1 mutants. rasa1 mutants develop cavernous AVMs that …

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The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activationin vitroand in a mouse model of systemic inflammation

Sylwia Wasiak, Li Fu, Emily Daze, Dean Gilham et autres

Abstract Brain vascular inflammation is characterized by endothelial activation and immune cell recruitment to the blood vessel wall, potentially causing a breach in the blood – brain barrier, brain parenchyma inflammation, and a decline of cognitive function. The clinical-stage small molecule, apabetalone, …

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