Sriram Yandrapally

Immunologically Optimized Zmp1 Peptides Reveal a Translational Serological Biomarker Platform for Tuberculosis Diagnosis Across Disease Manifestations

Omkar Shriram Zade, Sriram Yandrapally, Keerthana Choudhari, Akshay Vaijinath Gaikwad et autres

Abstract Tuberculosis (TB) diagnosis remains challenging, particularly for extrapulmonary TB (EPTB), where invasive sampling, low bacillary burden, and suboptimal sensitivity of nucleic acid-based tests in peripheral specimens hinder timely detection. Here, we report an immunology-driven strategy for biomarker discovery and development of …

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Riluzole Enhances Latency Reversal Agent Efficacy in ART-Suppressed PWH by Relieving hnRNPA1-Mediated HIV-RNA Nuclear Export Block

Satarupa Sarkar, Sriram Yandrapally, V. V. Ramprasad Eadara, Venkata Sanjeev Kumar Neela et autres

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Virion Associated Importin Subunit Beta‐1 Augments Nuclear Import of HIV ‐1 Pre‐Integration Complex

Sriram Yandrapally, Satarupa Sarkar, Venkateshwarlu Naik, Carsten Münk et autres

Import of proviral genome from the cytoplasm to the nucleus is a decisive step in the HIV-1 infection cycle, regulating which can decide the fate of HIV-1 infectivity. Exploring the heterogeneity in the replication potential of viruses emerging from various producer cells, …

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Monitoring the mitochondrial localization of mycobacterial proteins

Krishnaveni Mohareer, Jayashankar Medikonda, Sriram Yandrapally, Anushka Agarwal et autres

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Rv0547c, a functional oxidoreductase, supports Mycobacterium tuberculosis persistence by reprogramming host mitochondrial fatty acid metabolism

Jayashankar Medikonda, Nandini Wankar, Suman Asalla, Sufi Oasim Raja et autres

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The stage-specific regulation imposed by Importinβ-1 on HIV-1 propagation and infectivity dynamics

Sriram Yandrapally, Satarupa Sarkar, Shalini Saxena, Venkateshwarlu Naik et autres

Abstract Dynamics of intra-host molecular evolution of viruses depend on the complexities of the cellular environments through which they transit. HIV infects several cell types in an infected human host, especially during chronic stages, which impose differential regulations on HIV persistence, driving …

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Confronting Tuberculosis: A Synthetic Quinoline-Isonicotinic Acid Hydrazide Hybrid Compound as a Potent Lead Molecule Against Mycobacterium tuberculosis

Govinda Raju Vadankula, Vipul V. Nilkanth, Arshad Rizvi, Sriram Yandrapally et autres

The current tuberculosis (TB) treatment is challenged by a complex first-line treatment for drug-sensitive (DS) TB. Additionally, the prevalence of multidrug (MDR)- and extensively drug (XDR)-resistant TB necessitates the search for new drug prototypes. We synthesized and screened 30 hybrid compounds containing …

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The nuclear pore protein NUP98 impedes LTR-driven basal gene expression of HIV-1, viral propagation, and infectivity

Kumaraswami Chintala, Sriram Yandrapally, Warisha Faiz, Chhaya Rani Kispotta et autres

Nucleoporins (NUPs) are cellular effectors of human immunodeficiency virus-1 (HIV-1) replication that support nucleocytoplasmic trafficking of viral components. However, these also non-canonically function as positive effectors, promoting proviral DNA integration into the host genome and viral gene transcription, or as negative effectors …

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HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing

Sriram Yandrapally, Satarupa Sarkar, Sharmistha Banerjee

ABSTRACT Proliferation of HIV in astrocytes is limited when compared to CD4+ T lymphocytes, but the molecular mechanisms behind the disparity in cell-specific HIV propagations are unclear. In this study, we show that HIV-1 Tat determined nuclear export of Rev-viral RNA complex …

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Mycobacterium tuberculosis EspR modulates Th1-Th2 shift by transcriptionally regulating IL-4, steering increased mycobacterial persistence and HIV propagation during co-infection

Sriram Yandrapally, Anushka Agarwal, Archismita Chatterjee, Satarupa Sarkar et autres

Mycobacterium tuberculosis (Mtb) and HIV are known to mutually support each other during co-infection by multiple mechanisms. This synergistic influence could be either by direct interactions or indirectly through secreted host or pathogen factors that work in trans. Mtb secretes several virulence …

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Nucleoporin NUP98 suppresses the basal HIV-1 gene expression through its N-terminal domain

Kumaraswami Chintala, Sriram Yandrapally, Warisha Faiz, Chhaya Rani Kispotta et autres

Abstract Background: Nucleoporins (NUPs) are cellular effectors of HIV-1 replication that support nucleocytoplasmic trafficking of viral components, and non-canonically promote viral DNA integration into the host genome and proviral DNA transcription. However, some of the NUPs were also shown to aid the …

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HIV co-receptor-tropism: cellular and molecular events behind the enigmatic co-receptor switching

Sriram Yandrapally, Krishnaveni Mohareer, Geethika Arekuti, Govinda Raju Vadankula et autres

Recognition of cell-surface receptors and co-receptors is a crucial molecular event towards the establishment of HIV infection. HIV exists as several variants that differentially recognize the principal co-receptors, CCR5 and CXCR4, in different cell types, known as HIV co-receptor-tropism. The relative levels …

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