Arshad Rizvi

Biomarkers and Diagnostic and Therapeutic Approaches for Mycobacterial Diseases

Arshad Rizvi, Yash A. Gupta

Mycobacterial diseases, particularly tuberculosis (TB), continue to impose a substantial global health burden, disproportionately affecting populations in low- and middle-income countries [...].

us (code pays fourni par la source)

A metabolite dehydrogenase pathway represses sporulation of Clostridioides difficile

Daniela Wetzel, Arshad Rizvi, Adrianne N. Edwards, Shonna M. McBride

us (code pays fourni par la source)

The Pxp Complex Detoxifies 5‐Oxoproline and Promotes the Growth of Clostridioides difficile

Cheyenne D. Lee, Arshad Rizvi, Zavier A. Carter, Adrianne N. Edwards et autres

Clostridioides difficile is an anaerobic enteric pathogen that disseminates in the environment as a dormant spore. For C. difficile and other sporulating bacteria, the initiation of sporulation is a regulated process that prevents spore formation under favorable growth conditions. In Bacillus subtilis, …

us (code pays fourni par la source)

Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant Mycobacterium tuberculosis Strains

Govinda Raju Vadankula, Arshad Rizvi, Rakhi Khunjamayum, V. V. Ramprasad Eedara et autres

The long regimen of drug therapy, the emergence of drug-resistance (DR), and infections with non-tuberculous mycobacteria (NTMs) are alarming challenges in controlling tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (M.tb), necessitating the pursuit of new, broad-spectrum anti-mycobacterials. With more than two-thirds …

in (code pays fourni par la source)

Confronting Tuberculosis: A Synthetic Quinoline-Isonicotinic Acid Hydrazide Hybrid Compound as a Potent Lead Molecule Against Mycobacterium tuberculosis

Govinda Raju Vadankula, Vipul V. Nilkanth, Arshad Rizvi, Sriram Yandrapally et autres

The current tuberculosis (TB) treatment is challenged by a complex first-line treatment for drug-sensitive (DS) TB. Additionally, the prevalence of multidrug (MDR)- and extensively drug (XDR)-resistant TB necessitates the search for new drug prototypes. We synthesized and screened 30 hybrid compounds containing …

in (code pays fourni par la source)

KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile

Cheyenne D. Lee, Arshad Rizvi, Shonna M. McBride

ABSTRACT Clostridioides difficile is an anaerobic enteric pathogen that disseminates in the environment as a dormant spore. For C. difficile and other sporulating bacteria, the initiation of sporulation is a regulated process that prevents spore formation under favorable growth conditions. In Bacillus …

us (code pays fourni par la source)

Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin

Arshad Rizvi, Germán G. Vargas-Cuebas, Adrianne N. Edwards, Michael A. DiCandia et autres

ABSTRACT Clostridioides difficile is a leading cause of antibiotic-associated diarrheal disease. C. difficile colonization, growth, and toxin production in the intestine is strongly associated with its ability to use amino acids to generate energy, but little is known about the impact of …

us (code pays fourni par la source)

The predicted acetoin dehydrogenase pathway represses sporulation of Clostridioides difficile

Daniela Wetzel, Arshad Rizvi, Adrianne N. Edwards, Shonna M. McBride

ABSTRACT Clostridioides difficile is a major gastrointestinal pathogen that is transmitted as a dormant spore. As an intestinal pathogen, C. difficile must contend with variable environmental conditions, including fluctuations in pH and nutrient availability. Nutrition and pH both influence growth and spore …

us, de (code pays fourni par la source)

Glycine fermentation by C. difficile promotes virulence, spore formation, and is induced by host cathelicidin

Arshad Rizvi, Germán G. Vargas-Cuebas, Adrianne N. Edwards, Michael A. DiCandia et autres

SUMMARY The amino acid glycine is enriched in the dysbiotic gut and is suspected to contribute to Clostridioides difficile infection. We hypothesized that the use of glycine as an energy source contributes to colonization of the intestine and pathogenesis of C. difficile …

us (code pays fourni par la source)

IDF21-0043 Technology Trio: Continuous Glucose Monitoring, Telehealth, and Electronic Messaging for Insulin-Treated Patients

Arshad Rizvi

us (code pays fourni par la source)

Genetic mechanisms governing sporulation initiation in Clostridioides difficile

Cheyenne D. Lee, Arshad Rizvi, Adrianne N. Edwards, Michael A. DiCandia et autres

us (code pays fourni par la source)

Host manipulation by bacterial type III and type IV secretion system effector proteases

Flávia Viana, Shruthi Peringathara, Arshad Rizvi, Gunnar N. Schroeder

Proteases are powerful enzymes, which cleave peptide bonds, leading most of the time to irreversible fragmentation or degradation of their substrates. Therefore they control many critical cell fate decisions in eukaryotes. Bacterial pathogens exploit this power and deliver protease effectors through specialised …

gb (code pays fourni par la source)