Chiaki Sato

Clinical and Prognostic Impacts of Heme Oxygenase-1 Expression in Esophageal Squamous Cell Carcinoma Following Neoadjuvant Chemotherapy

Atsushi Kunimitsu, Hirotaka Ishida, Hironobu Sasano, Hiroyuki Oshikiri et autres

Esophageal squamous cell carcinoma (ESCC) is highly aggressive malignancy.Neoadjuvant chemotherapy (NAC) followed by surgery is the standard therapeutic strategy for patients with cStage II/III ESCC; however, chemoresistance remains challenging.The nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has been implicated …

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Correlation of growth differentiation factor 15 level in esophageal cancer with cachectic indicators and postoperative infectious complication

Yohei Ozawa, Hiroshi Okamoto, Yusuke Taniyama, Chiaki Sato et autres

BACKGROUND: Patients with esophageal cancer (EC) usually have multiple comorbidities, particularly, high cachexia incidence, which may lead to increased postoperative complications. A novel inflammatory marker, growth differentiation factor 15 (GDF15), was recently reported to be associated with cancer cachexia. This study evaluated …

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A Novel Approach for Cisplatin‐Resistant Esophageal Squamous Cell Carcinoma via Amino Acid Transporter LAT1 Inhibition

Takeru Mozumi, Narumi Harada‐Shoji, Yohei Ozawa, Yuto Yamazaki et autres

ABSTRACT Background Esophageal squamous cell carcinoma (ESCC) represents an aggressive cancer type associated with poor prognosis, often treated with neoadjuvant chemotherapy (NAC) using cisplatin‐based regimens. However, cisplatin resistance limits therapeutic efficacy, necessitating a deeper understanding of resistance mechanisms. L‐type amino acid transporter …

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450. HUMAN PAPILLOMAVIRUS STATUS BEFORE AND AFTER NEOADJUVANT CHEMOTHERAPY AND ITS ASSOCIATION WITH TREATMENT SENSITIVITY IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Kaiyuan Jiang, Hirotaka Ishida, Yusuke Taniyama, Chiaki Sato et autres

Abstract Background Our previous study confirmed that p16 is considered a reliable surrogate marker for Human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC). Since neoadjuvant chemotherapy (NAC) followed by esophagectomy is the standard treatment, p16 expression may be affected by …

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071. MICROVASCULAR ARCHITECTURE IN ESOPHAGEAL CANCER OBSERVED BY STEREOMICROSCOPY

Chyo Kobayashi, Fumiyoshi Fujishima, Hirotaka Ishida, I Sasaki et autres

Abstract Background Observation of microvascular structures using magnifying endoscopy is useful for distinguishing between tumor and non-tumor areas, as well as for diagnosing wall invasion depth in esophageal cancer. However, while magnifying endoscopy findings are often compared with histological vascular structures, the …

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215. OUTCOMES OF PERORAL ENDOSCOPIC MYOTOMY (POEM) FOR ESOPHAGEAL ACHALASIA IN PATIENTS UNDER 20 YEARS OLD

Chiaki Sato, I Sasaki, Jun Takahashi, Atsushi Kunimitsu et autres

Abstract Background Esophageal achalasia is a motility disorder characterized by impaired relaxation of the lower esophageal sphincter and loss of esophageal peristalsis. While the peak age of diagnosis is reported to be in the 40s to 50s, it can also occur during …

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030. PROGNOSTIC SIGNIFICANCE OF LOW HER2 EXPRESSION IN ADENOCARCINOMA OF THE ESOPHAGOGASTRIC JUNCTION: A RETROSPECTIVE ANALYSIS

Yusuke Gokon, Yohei Ozawa, Hirofumi Ichikawa, Yusuke Taniyama et autres

Abstract Background Human epidermal growth factor receptor 2 (HER2) is a key oncogene implicated in several cancers, including breast cancer, gastric cancer, and adenocarcinoma of the esophagogastric junction (AEG). While HER2-positive tumors benefit from established therapies like trastuzumab, the clinical significance of …

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Peroral Endoscopic Myotomy for Esophageal Achalasia : Introduction and Treatment Outcomes

Chiaki Sato, Takashi Kamei

Clinical Characteristics and Long‐Term Efficacy of Peroral Endoscopic Myotomy in Pediatric Achalasia

Yuto Shimamura, Hiroki Sato, Ryusuke Yagi, Hirofumi Abe et autres

BACKGROUND AND AIMS: Pediatric achalasia and peroral endoscopic myotomy (POEM) are not well investigated. This study aimed to examine the clinical characteristics of pediatric achalasia and evaluate the long-term outcomes of POEM. METHODS: We conducted a multicenter study across 14 high-volume centers, …

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Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer

Seji Asamitsu, Yohei Ozawa, Hiroshi Okamoto, Seiryo Ogata et autres

Early detection of esophageal cancer is essential for esophagogastroduodenoscopy and histopathological diagnosis. However, endoscopic examinations are sometimes invasive, which limits their clinical application and compliance, and traditional blood tumor markers are unsuitable for cancer screening. The current study aimed to evaluate the …

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Multimodal deep-learning model using pre-treatment endoscopic images and clinical information to predict efficacy of neoadjuvant chemotherapy in esophageal squamous cell carcinoma

Takuma Miura, Eichi Takaya, Yusuke Taniyama, Chiaki Sato et autres

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Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer

Iku Sasaki‐Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama et autres

Fusobacterium nucleatum is implicated in esophageal cancer; however, its distribution in esophageal cancer tissues remains unknown. This study aimed to clarify the presence and distribution of F. nucleatum in esophageal cancer tissues using fluorescence in situ hybridization (FISH). Tissues collected from 70 …

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