Alan Yi-Hui Hsu

Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

Yueh‐Chien Lin, Takahiro Seno, Alan Yi-Hui Hsu, Andréane Cartier et autres

Sphingosine 1-phosphate (S1P), a lipid mediator that signals through five G protein-coupled S1P receptors (S1PRs), regulates T cell trafficking, tissue residency, and inflammatory processes. In contrast to the established roles of S1P signaling in T cell trafficking, its role in neutrophil biology …

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Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

Yueh‐Chien Lin, Takahiro Seno, Alan Yi-Hui Hsu, Andréane Cartier et autres

Sphingosine 1-phosphate (S1P), a lipid mediator that signals through five G protein-coupled S1P receptors (S1PRs), regulates T cell trafficking, tissue residency, and inflammatory processes. In contrast to the established roles of S1P signaling in T cell trafficking, its role in neutrophil biology …

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Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

Yueh‐Chien Lin, Takahiro Seno, Alan Yi-Hui Hsu, Andréane Cartier et autres

ABSTRACT Sphingosine 1-phosphate (S1P), a lipid mediator that signals through five G protein-coupled S1P receptors (S1PRs), regulates T cell trafficking, tissue residency, and inflammatory processes. In contrast to the established roles of S1P signaling in T cell trafficking, its role in neutrophil …

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RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization

Daniel H. Kim, Ramizah Syahirah, Conwy Zheng, Chang Kui Ding et autres

Neutrophils are the first responders of our innate immune system, crucial for defense against various infections. The intricate regulation of neutrophil migration is essential for neutrophil function. However, a complete mechanistic understanding is missing. We previously performed a miRNA overexpression screen and …

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Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution 9058

Alan Yi-Hui Hsu, Hongbo Robert Luo

Abstract Description Although subsets with immunosuppressive properties exist, neutrophils are typically known for their pro-inflammatory role and pathogen clearance capabilities. Here, we reveal that neutrophils can paradoxically aid in resolving inflammation by actively producing anti-inflammatory extracellular vesicles. These large aging neutrophil-derived vesicles …

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258 Functional correction of CFTR-G542X in human bronchial epithelial cells using a Type I CRISPR adenine base editor with a guide-length- tunable editing window

Zhiyong Hou, Martin Grosvenor Myers, Jianshe Chen, Kai Zhao et autres

Neutrophil death-more than meets the eye

Alan Yi-Hui Hsu, Qingxiang Huang, Fei Liu, Arumugam Balasubramanian et autres

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Protocol to isolate and quantify large aging neutrophil-derived vesicles

Alan Yi-Hui Hsu, Qingxiang Huang, Sizhou Feng, Hongbo Robert Luo

Large aging neutrophil-derived vesicles (LAND-Vs) are ∼1 μm ectosomes released by aging neutrophils. Here, we present a protocol to identify and purify murine LAND-Vs from in vitro neutrophil cultures and ex vivo sources, including bone marrow, blood, and bronchoalveolar lavage fluid (BALF), …

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Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution

Alan Yi-Hui Hsu, Qingxiang Huang, Xiong Pi, Jianing Fu et autres

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IQGAP1 Influences Neutrophil Maturation and Its Effector Functions

Lifei Hou, Alan Yi-Hui Hsu, Hongbo Robert Luo, Koichi Yuki

IQ motif containing GTPase activating protein 1 (IQGAP1) is a protein scaffold that integrates signals regulating various cellular functions. Recently, utilizing proteomics as a discovery tool and co-immunoprecipitation as a validation method, we reported IQGAP1 as a potential ligand for CD11c, an …

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Author response for "IQGAP1 Influences Neutrophil Maturation and Its Effector Functions"

Lifei Hou, Alan Yi-Hui Hsu, Hongbo Robert Luo, Koichi Yuki

Re: Hwang et al: Ocular Adverse Events Following COVID-19 Infection: A Self-controlled Case Series Study from the Entire Korean Population

Alan Yi-Hui Hsu, Chun‐Ju Lin, Huan‐Sheng Chen, Yi-Yu Tsai

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