Lærke Priskorn

Marginal Changes in Semen Quality Over Three Decades (1996‒2022) Among 8320 Men in the Danish Young Men Study (DYMS): Cohort Profile and Trends

Lærke Priskorn, Cille Baslund‐Storch, Laura S Hansen, Astrid Beck et autres

BACKGROUND: Since the 1990s, declining sperm counts and increasing testicular cancer rates have raised worldwide concern about male reproductive health, including in Denmark. This prompted a prospective population-based study with annual surveillance of semen quality. OBJECTIVE: This paper presents a detailed profile …

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Associations Between Sperm DNA Fragmentation and Lifestyle Factors

Lana Haval Mairof Adams, Lærke Priskorn, Joan‐Carles Arce, Heidi Aasted et autres

BACKGROUND: Sperm DNA fragmentation index (DFI) has been proposed as a supplementary biomarker to traditional semen parameters in the evaluation of male infertility. However, its determinants and clinical relevance remain unclear, particularly regarding modifiable lifestyle factors. This study investigated associations between DFI, …

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Isotretinoin use is associated with persistent alterations in male reproductive function

Fie Bendix, Lærke Priskorn, Niels Jørgensen, Hanne Frederiksen et autres

Abstract Background Isotretinoin (ISO) is a systemic retinoid widely used for the treatment of acne vulgaris , yet its potential effects on male reproductive function remain unclear with previous studies reporting inconsistent findings. Methods and findings We conducted a multi-model study combining …

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Concentrations of 4-hydroxychlorothalonil in serum from pregnant women and the association with risk of testicular germ cell cancer in their male offspring

Cecilie S. Uldbjerg, Christian Lindh, David M. Kristensen, Youn‐Hee Lim et autres

INTRODUCTION: Testicular germ cell cancer (TGCC) is hypothesized to originate from disruptions of fetal testis development, potentially caused by environmental chemicals. One potential risk factor is 4-hydroxychlorothalonil (4-OH-CHT), a primary transformation product of fungicide chlorothalonil, which is banned across the European Union. …

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High Seminal Fluid Calcium Is Associated With Higher Sperm Concentration in Infertile Men and Men From the General Population

Sam Kafai Yahyavi, Frederikke Bay Toft, Benedicte Probst‐Drejer, Ida Marie Boisen et autres

BACKGROUND: The extracellular calcium concentration is important for sperm function, maturation, and survival, however, studies exploring the link between seminal calcium and reproductive function have reported inconsistent findings. OBJECTIVES: To investigate the association between seminal calcium levels and semen quality in both …

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Fetal exposure to paracetamol is associated with altered markers of ovarian development and reduced uterine volume in girls: the COPANA study

Margit Bistrup Fischer, Gylli Mola, Karin Sundberg, Lone Scheel et autres

STUDY QUESTION: Is fetal exposure to paracetamol associated with markers of ovarian function in infancy? SUMMARY ANSWER: Mild to moderate doses of prenatal paracetamol exposure, assessed by detailed maternal reports and urinary measurements, are associated with ovarian morphology and activity as well …

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Evidence that declining human fecundity contributes to the fertility crisis

Rune Lindahl‐Jacobsen, Astrid Beck, Lærke Priskorn, Stine Agergaard Holmboe et autres

Fertility rates have fallen to unprecedentedly low levels worldwide, reflecting a widespread fertility crisis. Although this decline has often been attributed to social and economic shifts, growing evidence suggests that biological factors may also play a role. Markers of decreased fecundity are …

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Health behaviors in women conceiving by medically assisted reproduction vs natural conception: A cross‐sectional study of 23,334 nulliparous women

Ann Holm Hansen, Lærke Priskorn, Niels Jørgensen, Nina Olsén Nathan et autres

INTRODUCTION: Women conceiving by medically assisted reproduction (MAR) have a planned pregnancy, easing adherence to preconception recommendations, which they are expected to be highly motivated to comply with. However, little is known about the actual adherence among these women. Thus, we investigate …

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Exposure to per- and polyfluoroalkyl substances during fetal development and risk of testicular germ cell cancer in adulthood

Cecilie S. Uldbjerg, Youn‐Hee Lim, Astrid Beck, Jørgen Holm Petersen et autres

BACKGROUND: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and …

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Changes in the comprehensive unassisted pregnancy rate as a possible marker of declining human fecundity

Rune Lindahl‐Jacobsen, Astrid Beck, Lærke Priskorn, Stine Agergaard Holmboe et autres

Recent decades have seen declining total fertility rates (TFR) globally, alongside increased use of assisted reproductive technology (ART). However, TFR includes ART births and excludes induced abortions, complicating assessments of population fecundity. Here, we examine trends in cohort total fertility rates (cTFR), …

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Semen Quality and Lifespan: A Study of 78,284 Men Followed for Up to 50 Years

Lærke Priskorn, Rune Lindahl‐Jacobsen, Tina Kold Jensen, Stine Agergaard Holmboe et autres

(Abstracted from Hum Reprod 2025;40(4):730–738 Recent evidence has shown that semen quality may be associated with other key factors in men other than fertility and reproductive health, such as a higher lifetime incidence of disease or a shorter life expectancy. In addition, …

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Human reproduction in crisis: causes unknown

Niels E. Skakkebæk, Lærke Priskorn, Rune Lindahl‐Jacobsen, Anna‐Maria Andersson et autres

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