Gylli Mola

Prenatal antifungal exposure disrupts fetal steroidogenesis and is associated with persistent effects in children

Gylli Mola, Monica Kam Draskau, Anne Jørgensen, Frédéric Chalmel et autres

Exposure to endocrine-disrupting chemicals (EDCs) during fetal life is associated with reproductive disorders in humans. While research has largely focused on environmental EDCs and developmental exposure, some pharmaceuticals, including commonly used antifungal agents, also possess endocrine-disrupting properties. We investigate whether prenatal exposure …

dk, fr, ch (code pays fourni par la source)

Fetal exposure to paracetamol is associated with altered markers of ovarian development and reduced uterine volume in girls: the COPANA study

Margit Bistrup Fischer, Gylli Mola, Karin Sundberg, Lone Scheel et autres

STUDY QUESTION: Is fetal exposure to paracetamol associated with markers of ovarian function in infancy? SUMMARY ANSWER: Mild to moderate doses of prenatal paracetamol exposure, assessed by detailed maternal reports and urinary measurements, are associated with ovarian morphology and activity as well …

dk, gb (code pays fourni par la source)

Corrigendum to “Maternal application of topical antifungal medication is associated with reduced steroid hormone levels during minipuberty and shorter anogenital distance in offspring from 3 months to 9 years of age: Odense Child Cohort” [Reprod. Toxicol. (2025) 109007 137]

Sarah Munk Andreasen, Lars Lund, Margit Bistrup Fischer, Anna‐Maria Andersson et autres

dk (code pays fourni par la source)

Maternal application of tropical antifungal medication is associated with reduced steroid hormone levels during minipuberty and shorter anogenital distance in offspring from 3 months to 9 years of age: Odense Child Cohort

Sarah Munk Andreasen, Lars Lund, Margit Bistrup Fischer, Anna‐Maria Andersson et autres

Vaginal candidiasis affects about 20 % of pregnant women and is usually treated with over-the-counter topical antifungal medication (azoles). Vaginal or transdermal application of azoles are absorbed and detectable in circulation. Azoles inhibit CYP51, which is crucial for the integrity of fungal …

dk (code pays fourni par la source)

Extensive exposure to di-n-hexyl phthalate with significant seasonal variation across infants, children and adults including pregnant women in Denmark

Hanne Frederiksen, Holger M. Koch, Stine Müller, Margit Bistrup Fischer et autres

BACKGROUND: Di-n-hexyl phthalate (DnHxP) is one of the most potent phthalates with adverse effects on the male reproductive system. Despite a European ban on DnHxP since 2020, high urinary excretion of mono-n-hexyl phthalate (MnHxP), the major metabolite of DnHxP, has been observed …

dk, de (code pays fourni par la source)

Maternal urinary paracetamol concentrations and self-reported paracetamol use in mid-gestation: Association to reduced anogenital distance in Offspring from infancy to 9 years

Sarah Munk Andreasen, Lars Lund, Casper P. Hagen, Margit Bistrup Fischer et autres

Studies have found associations between self-reported paracetamol use during pregnancy and shorter anogenital distance (AGD) in male infants, suggesting paracetamol have antiandrogenic properties. We investigated whether self-reported paracetamol use or quantified paracetamol concentration in maternal urine was associated with AGD in offspring …

dk (code pays fourni par la source)

Exposure to phthalates at the masculinization programming window is associated with longer anogenital distance and reduced birth weight in healthy children: A COPANA cohort study of 589 infants

Gylli Mola, Fischer Margit Bistrup, Emilie Zeuthen, Hanne Frederiksen et autres

Paternal use of paracetamol prior to conception is associated with elevated adrenal steroid levels in female infants - a copana study

Emilie Zeuthen, Fischer Margit Bistrup, Gylli Mola, Anna‐Maria Andersson et autres

Delivery mode is associated with persistent changes of steroid hormone levels in boys at three months of age - a COPANA study of 508 healthy infants

Andrea Bogehave, Gylli Mola, Hanne Frederiksen, Karin Sundberg et autres

Maternal urinary paracetamol is associated with reduced uterine size and breast tissue diameter at infancy: a COPANA cohort study of 302 healthy girls

Fischer Margit Bistrup, Gylli Mola, Hanne Frederiksen, Karin Sundberg et autres

Extensive Exposure to Di-N-Hexyl Phthalate with Significant Seasonal Variation Across Infants, Children and Adults Including Pregnant Woman in Denmark

Hanne Frederiksen, Holger M. Koch, Stine Müller, Margit Bistrup Fischer et autres

dk, de (code pays fourni par la source)

Ovarian and Uterine Morphology in Minipuberty: Associations With Reproductive Hormones: a COPANA Study of 302 Girls

Margit Bistrup Fischer, Gylli Mola, Ane Lilleøre Rom, Hanne Frederiksen et autres

CONTEXT: Female minipuberty is characterized by complex dynamics of circulating reproductive hormones, while the relationship between ovarian and uterine morphology and reproductive hormones remains to be elucidated. OBJECTIVE: This work aimed to investigate the association between reproductive hormones and ovarian as well …

dk (code pays fourni par la source)