Chaitra Parthiban

Immunogenicity of SARS-CoV-2 vaccines BBV152 (COVAXIN®) and ChAdOx1 nCoV-19 (COVISHIELD™) in seronegative and seropositive individuals in India: a multicentre, nonrandomised observational study

Mangaiarkarasi Asokan, Roshni Florina Joan, Sudhir Babji, Girish Dayma et autres

Background: There are limited global data on head-to-head comparisons of vaccine platforms assessing both humoral and cellular immune responses, stratified by pre-vaccination serostatus. The COVID-19 vaccination drive for the Indian population in the age group 18-45 years began in April 2021 when …

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More time to kill: A longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria

Naveen Yadav, Chaitra Parthiban, Zachary P. Billman, Brad Stone et autres

Liver stage (LS) Plasmodia mature in 2–2.5 days in rodents compared to 5–6 days in humans. Plasmodium -specific CD8 + T cell expansion differs across these varied timespans. To mimic the kinetics of CD8 + T cells of human Plasmodium infection, a …

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Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians

Srabanti Rakshit, Sudhir Babji, Chaitra Parthiban, Ramya Madhavan et autres

(CS) and COVAXIN® (CO) in a pre-exposed population is only recently being discovered. We addressed this issue in subjects who received their primary series of vaccination between November 2021 and January 2022. Both vaccines are capable of strongly boosting Wuhan Spike-specific neutralising …

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BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways

Asma Ahmed, Himanshu Tripathi, Krista E. van Meijgaarden, Nirutha Chetan Kumar et autres

This study characterized mechanisms of Bacille Calmette-Guérin (BCG) revaccination-induced trained immunity (TI) in India. Adults, BCG vaccinated at birth, were sampled longitudinally before and after a second BCG dose. BCG revaccination significantly elevated tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 …

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Preliminary studies on the immunogenicity of a prime-and-trap malaria vaccine in nonhuman primates

Melanie J. Shears, Felicia Watson, Brad Stone, Irene Cruz Talavera et autres

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Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic

Büsra Geckin, Martijn Zoodsma, Gizem Kılıç, Priya A. Debisarun et autres

In this study, we assessed the differences in immune responses in individuals from India and Europe. This aspect is of great relevance, because of the described differences in morbidity and mortality between India and Europe during the pandemic. We found a significant …

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Interim results from comparison of immune responses elicited by an inactivated and a vectored SARS-CoV-2 vaccine in seronegative and seropositive participants in India

Mangaiarkarasi Asokan, Roshni Florina Joan, Sudhir Babji, Girish Dayma et autres

Abstract Background There are limited global data on head-to-head comparisons of vaccine platforms assessing both humoral and cellular immune responses, stratified by pre-vaccination serostatus. The COVID-19 vaccination drive for the Indian population in the 18 to 45-year age-group began in April 2021 …

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More Time to Kill: The Effect of Liver Stage Duration on CD8 T Cell-Mediated Protection Against Pre-Erythrocytic Malaria

Naveen Yadav, Chaitra Parthiban, Zachary P. Billman, Brad Stone et autres

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BCG Revaccination of Young Indian Adults Enhances Pro-Inflammatory Markers of Trained Immunity with Concomitant Induction of Major Anti-Inflammatory Pathways

Asma Ahmed, Himanshu Tripathi, Krista E. van Meijgaarden, Nirutha Chetan et autres

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Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Srabanti Rakshit, Vasista Adiga, Asma Ahmed, Chaitra Parthiban et autres

This proof-of-concept study tested if prior BCG revaccination can qualitatively and quantitively enhance antibody and T-cell responses induced by Oxford/AstraZeneca ChAdOx1nCoV-19 or COVISHIELD™, an efficacious and the most widely distributed vaccine in India. We compared COVISHIELD™ induced longitudinal immune responses in 21 …

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Needle-free, spirulina-produced Plasmodium falciparum circumsporozoite vaccination provides sterile protection against pre-erythrocytic malaria in mice

Tracy Saveria, Chaitra Parthiban, Annette M. Seilie, Colin Brady et autres

Abstract Antibodies against the Plasmodium falciparum circumsporozoite protein (PfCSP) can block hepatocyte infection by sporozoites and protect against malaria. Needle-free vaccination strategies are desirable, yet most PfCSP-targeted vaccines like RTS,S require needle-based administration. Here, we evaluated the edible algae, Arthrospira platensis (commonly …

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Differences in anti-viral immune responses in individuals of Indian and European origin: relevance for the COVID-19 pandemic

Büsra Geckin, Martijn Zoodsma, Gizem Kılıç, Priya A. Debisarun et autres

Abstract During the COVID-19 pandemic, large differences in susceptibility and mortality due to SARS-CoV-2 infection have been reported between populations in Europe and South Asia. While both host and environmental factors (including BCG vaccination) have been proposed to explain this, the potential …

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