Karina Guttek

Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults

Matthias Raschick, Anni Richter, Larissa Fischer, Lea Knopf et autres

Abstract Human cognitive abilities, and particularly hippocampus-dependent memory performance typically decline with increasing age. Immunosenescence, the age-related disintegration of the immune system, is increasingly coming into the focus of research as a considerable factor contributing to cognitive decline. In the present study, …

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Zinc aspartate induces proliferation of resting and antigen-stimulated human PBMC under high-density cell culture condition

Karina Guttek, Annegret Reinhold, Kurt Grüngreiff, Burkhart L. Schraven et autres

BACKGROUND: Zinc, one of the most important essential trace elements in the human body, regulates a wide range of cellular functions of immune cells, such as proliferation, differentiation and survival. Zinc deficiency affects both the innate and adaptive immune system. Zinc supplementation …

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The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation

Dirk Reinhold, Vadim M. Farztdinov, Yan Yan, Christian Meisel et autres

Patients with COVID-19 can have a variety of neurological symptoms, but the active involvement of central nervous system (CNS) in COVID-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 generally show no or only mild …

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Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults

Matthias Raschick, Anni Richter, Larissa Fischer, Lea Knopf et autres

Abstract Human cognitive abilities, and particularly hippocampus-dependent memory performance typically decline with increasing age. Immunosenescence, the age-related disintegration of the immune system, is increasingly coming into the focus of research as a considerable factor contributing to cognitive decline. In the present study, …

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The Brain Reacting to COVID-19: Analysis of the Cerebrospinal Fluid and Serum Proteome,Transcriptome and Inflammatory Proteins

Dirk Reinhold, Vadim M. Farztdinov, Yan Yan, Christian Meisel et autres

Abstract Patients with COVID-19 can have a variety of neurological symptoms, but the pathomechanism of CNS involvement in COVD-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 generally show no or only mild inflammation, more …

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Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation

Linda D Voss, Karina Guttek, Annika Reddig, Annegret Reinhold et autres

Repositioning of approved drugs is an alternative time- and cost-saving strategy to classical drug development. Statins are 3-hydroxy-3-methylglutaryl-CoA (HMG CoA) reductase inhibitors that are usually used as cholesterol-lowering medication, and they also exhibit anti-inflammatory effects. In the present study, we observed that …

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Impact of Different JAK Inhibitors and Methotrexate on Lymphocyte Proliferation and DNA Damage

Annika Reddig, Linda D Voss, Karina Guttek, Dirk Roggenbuck et autres

Janus kinase inhibitors (JAKis) represent a new strategy in rheumatoid arthritis (RA) therapy. Still, data directly comparing different JAKis are rare. In the present in vitro study, we investigated the immunomodulatory potential of four JAKis (tofacitinib, baricitinib, upadacitinib, and filgotinib) currently approved …

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Zinc Aspartate Induces IL-16 Secretion and Apoptosis in Human T Cells

Dirk Reinhold, Karina Guttek, Annika Reddig, Linda D Voss et autres

T cell activation mediates immunity to pathogens. On the flipside, T cells are also involved in pathological immune responses during chronic autoimmune diseases. We recently reported that zinc aspartate, a registered drug with high bioavailability, dose-dependently inhibits T cell activation and Th1/Th2/Th17 …

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Screening of FDA-Approved Drug Library Identifies Adefovir Dipivoxil as Highly Potent Inhibitor of T Cell Proliferation

Linda D Voss, Karina Guttek, Annika Reddig, Annegret Reinhold et autres

Repositioning of approved drugs for identifying new therapeutic purposes is an alternative, time and cost saving strategy to classical drug development. Here, we screened a library of 786 FDA-approved drugs to find compounds, which can potentially be repurposed for treatment of T …

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Serum and CSF cytokine levels mirror different neuroimmunological mechanisms in patients with LGI1 and Caspr2 encephalitis

Péter Körtvelyessy, Alexander Goihl, Karina Guttek, Burkhart L. Schraven et autres

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Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE

Jochen M. Rudolph, Clara Antonia Meinke, Martin Voß, Karina Guttek et autres

The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is …

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Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP

Jochen M. Rudolph, Karina Guttek, G. Weitz, Clara Antonia Meinke et autres

The adhesion and degranulation-promoting adapter protein (ADAP) is expressed in T cells, NK cells, myeloid cells, and platelets. The involvement of ADAP in the regulation of receptor-mediated inside-out signaling leading to integrin activation is well characterized, especially in T cells and in …

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