Margherita Macera

Efficacy of fluoroquinolone prophylaxis in high-risk neutropenic patients with haematological malignancies: a systematic review with meta-analysis

Lorenzo Onorato, Margherita Macera, Mariagrazia Palamone, Francesca Ambrisi et autres

Abstract Objectives To compare the clinical and microbiological outcomes of high-risk neutropenic patients receiving or not fluoroquinolone prophylaxis. Study eligibility criteria Randomized controlled trials (RCTs) and observational studies investigating overall mortality and rate of febrile episodes, of bloodstream infections and of isolation …

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Predictors of mortality and therapeutic efficacy in carbapenem-resistant Acinetobacter baumannii bacteremia

Alessandro Russo, Sara Palma Gullì, Antonio Vena, Luigi Spadafora et autres

OBJECTIVES: Bacteremia caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is associated with high morbidity and mortality. The primary objective was to identify clinical and therapeutic factors associated with 14- and 30-day mortality following infection onset. METHODS: This was a prospective, observational, multicenter study …

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Osteomyelitis of the Hip due to Granulicatella adiacens : A Case Report of an Extremely Rare Cause of Bone Infection

Niccolò Garofalo, Lorenzo Onorato, Margherita Macera, Ilaria De Luca et autres

Background Granulicatella adiacens (G. adiacens) is a nutritionally variant Streptococcus generally observed in the human mouth microbiota. Although G . adiacens is involved in bacterial endocarditis and bacteremia, bone and joint infections are extremely rare. In the present study, we reported the …

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Impact of a persuasive antimicrobial stewardship program on antibiotic use in patients admitted to emergency department for urinary tract infections: a multicentre prospective study

Margherita Macera, Annabella Salvati, Enrico Allegorico, Caterina Monari et autres

BACKGROUND: The spread of antibiotic resistance makes it necessary to implement Antimicrobial Stewardship (AMS) Programs; the aim of this study is to evaluate the impact of an AMS program in the management of urinary tract infection (UTI) in emergency setting. METHODS: A …

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Correction: Bacteremic nosocomial pneumonia caused by Gram-negative bacilli: results from the nationwide ALARICO study in Italy

Giusy Tiseo, Valentina Galfo, Sergio Carbonara, Andrea Marıno et autres

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Prevalence and outcomes of Urinary tract infections caused by Enterobacterales resistant to third-generation cephalosporins in the Emergency Department: results from UTILY cohort, a prospective multicentre study

Caterina Monari, Lorenzo Onorato, Alessandro Cornelli, Margherita Macera et autres

INTRODUCTION: In accordance with the spread of drug-resistant bacteria worldwide, an increase in the prevalence of Antimicrobial Resistance (AMR) among pathogens causing urinary tract infections (UTIs) has been described globally. The aim of this study was to describe the prevalence and outcome …

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Building on the UTILY Study: Exploring uncharted aspects of multidrug-resistant pathogens in urinary tract infections. Author's reply

Lorenzo Onorato, Margherita Macera, Caterina Monari, Nicola Coppola

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Prevalence and impact of multidrug resistance in a cohort of patients admitted to emergency department for urinary tract-infections: The UTILY study, a prospective multicentre study

Lorenzo Onorato, Enrico Allegorico, Margherita Macera, Caterina Monari et autres

BACKGROUND AND AIM: The aim of the present study was to evaluate the prevalence and to identify the independent predictors of multi-drug resistance among a cohort of patients admitted to emergency department for urinary tract infections (UTI), and to assess the impact …

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Bacteremic nosocomial pneumonia caused by Gram-negative bacilli: results from the nationwide ALARICO study in Italy

Giusy Tiseo, Valentina Galfo, Sergio Carbonara, Andrea Marıno et autres

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Effects of lenvatinib on glucose, cholesterol, triglycerides and estimated cardiovascular risk in patients with advanced thyroid cancer

Elisa Acitelli, Antonella Verrienti, Marialuisa Sponziello, Valeria Pecce et autres

PURPOSE: Multitarget kinase inhibitors (MKIs) are effective options in the treatment of cancer, significantly increasing the progression-free survival (PFS) of many tumors. Data about severity and prevalence of metabolic adverse events is scarce and may be significant in patients with a better …

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Impact of a persuasive antimicrobial stewardship programme on the appropriateness of surgical antimicrobial prophylaxis in a tertiary care hospital in southern Italy

Lorenzo Onorato, Margherita Macera, Caterina Curatolo, Viraj Pattapola et autres

• One of the most common indications for antibiotic use in the hospital setting is surgical perioperative prophylaxis. • However, limited data are available in the literature on the adherence to international and local guidelines in daily practice. • The rate of …

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Effectiveness of test-and-treat model with direct-acting antiviral for hepatitis C virus infection in migrants: a prospective interventional study in Italy

Nicola Coppola, Loredana Alessio, Stefania De Pascalis, Margherita Macera et autres

BACKGROUND: Migrants, mainly undocumented and low-income refugees, are at high risk of hepatitis C virus (HCV) infection, but are a difficult-to-reach and to-treat population. The aim of the study was to evaluate the effectiveness of a test and treat model with direct-acting …

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