Valerio Brucato

Thermally induced phase separation as a heat exchange-driven technique to produce poly-(L-lactic acid) scaffolds with controlled-gradient pore size morphology

Dario Davì, Camilla Carbone, Valerio Brucato, Giulio Ghersi et autres

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

G Caldara, Salvatrice Rigogliuso, Francesco Carfì Pavia, Valerio Brucato et autres

Poly-L-lactic acid (PLLA), a hemicrystalline material, has been extensively studied in applications of engineered tissues, because it is biodegradable, absorbable and it supports cell attachment and growth. The purpose of this study is to evaluate tissue/ material interactions, neovascularization and the biocompatibility …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Gaetano Felice, Salvatrice Rigogliuso, Francesco Carfì, Valerio Brucato et autres

Angiogenesis is essential in tissue integration and it is involved in the biological response to biomaterials. Poly-L-lactic acid (PLLA), a synthetic polymer, is utilized as scaffolding to regenerate new tissues. This study investigated the short and long term degradation and the induction …

Hybrid SES–MEW Scaffold Strategies: A Narrative Review of Multi-Scale Fiber Architectures for Soft and Hard Tissue Engineering

Elisa Capuana, Valerio Brucato, Vincenzo La Carrubba

Solution electrospinning (SES) and melt electrowriting (MEW) are complementary fiber-based fabrication platforms extensively investigated in tissue engineering. SES generates fibers typically ranging from the nanometer to the low-micrometer scale, producing fibrous networks that mimic the native extracellular matrix (ECM) and support key …

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Rheological Behavior, Filament Stability, and Microstructure of an Extrusion-Processable Kefiran–PG Formulation

Elisa Capuana, Emmanuel Fortunato Gulino, Roberto Scaffaro, Valerio Brucato et autres

Microbial polysaccharides are attracting increasing interest as water-processable polymers for extrusion-based additive manufacturing due to their ability to form physically stabilized networks without covalent cross-linking. In this study, a kefiran–propylene glycol (PG) formulation was developed to investigate whether time-dependent supramolecular reorganization can …

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Advanced Biomaterial-Based In Vitro Osteoarthritis Models: Integrating Sex as a Biological Variable in Hormonal, Subchondral Bone, and Mechanobiological Pathways

Elisa Capuana, Angela De Luca, Viviana Costa, Lavinia Raimondi et autres

Osteoarthritis (OA) is the most common form of arthritis and represents a major clinical and socioeconomic burden. Epidemiological data consistently show that OA affects women more frequently and, in several joints, more severely than men. Nevertheless, current in vitro models rarely consider …

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Data collection and correlation analysis of patient-specific dialytic variables for the development of an AI assistance therapeutic tool

Alessia Nicosia, Nunzio Cancilla, Eleonora Di Liberti, José D. Martín Guerrero et autres

The increasing prevalence of chronic kidney disease has led to a rise in the number of patients requiring dialytic therapies. These treatments, although essential for blood purification, are often associated with complications such as hypotension, fluid overload, and patient discomfort that traditional …

Performance Comparison of Machine Learning Models for the Prediction of Dialysis Treatment Variables

Alessia Nicosia, Nunzio Cancilla, E. Di Liberti, José D. Martín‐Guerrero et autres

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Continuous pore size gradient enhances zonal-specific differentiation of stem cells in an osteochondral scaffold

Gioacchino Conoscenti, Kyra W.Y. Smith, Alessandro Pirosa, Francesco Carfì Pavia et autres

environment. Our findings suggested that the PLLA continuous pore-gradient structure may offer a clinically translatable solution to osteochondral defect repair by supporting zone-specific differentiation.

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PLLA Porous Scaffold as a 3D Breast Cancer Model to Investigate Drug Resistance

Camilla Carbone, Salvatrice Rigogliuso, Valerio Brucato, Alessandra Cusimano et autres

ABSTRACT Multidrug resistance remains one of the major challenges in breast cancer research, often leading to treatment failure. To better understand this mechanism, sophisticated three‐dimensional (3D) tumor models are necessary, as they offer several advantages over traditional bidimensional (2D) cultures. In this …

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Poly-l-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess The Morphology, Thermal Behavior, and Hydrophilicity

Veronica Schiera, Francesco Carfì Pavia, Vincenzo La Carrubba, Valerio Brucato et autres

This study aims to demonstrate the possibility of incorporating a natural antioxidant biomolecule into polymeric porous scaffolds. To this end, Poly-l-Lactic Acid (PLLA) scaffolds were produced using the Thermally Induced Phase Separation (TIPS) technique and additivated with different amounts of rosmarinic acid …

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Poly-L-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess the Morphology, Thermal Behavior, and Hydrophilicity

Veronica Schiera, Francesco Carfì Pavia, Vincenzo La Carrubba, Valerio Brucato et autres

This study aims to demonstrate the possibility of incorporating a natural antioxidant biomolecule, into polymeric porous scaffolds. To this end, Poly-L-Lactic Acid (PLLA) scaffolds were produced using the Thermally Induced Phase Separation (TIPS) technique and additivated with different amounts of Rosmarinic Acid …

it (code pays fourni par la source)