James V. Price

Correction: The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye

Lauren M. Del Bel, Nigel W. Griffiths, Ronit Wilk, Ho-Chun Wei et autres

There was an error in Development (2018) 145, dev151571 (doi:10.1242/dev.151571).The amino acid sequence reported as corresponding to the temperature-sensitive mutation in Drosophila Sac1, and tested for protein stability via tissue culture, was incorrect.Rather than the amino acid substitution G382R, the point mutation …

Supporting the democratization of science during a pandemic: genomics Course-based Undergraduate Research Experiences (CUREs) as an effective remote learning strategy

David E. Lopatto, S. Catherine Silver Key, Melanie Van Stry, Jamie L. Siders et autres

ABSTRACT The initial phase of the COVID-19 pandemic changed the nature of course delivery from largely in-person to exclusively remote, thus disrupting the well-established pedagogy of the Genomics Education Partnership (GEP; https://www.thegep.org ). However, our web-based research adapted well to the remote …

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Student Attitudes Contribute to the Effectiveness of a Genomics CURE

David E. Lopatto, Anne Rosenwald, Rebecca C. Burgess, Catherine Silver Key et autres

The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work …

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Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience

David E. Lopatto, Anne Rosenwald, Justin R. DiAngelo, Amy T. Hark et autres

A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability is essential to being a successful scientist, but replicating such challenges in a teaching setting can be difficult. The Genomics Education Partnership (GEP) …

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The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye

Lauren M. Del Bel, Nigel W. Griffiths, Ronit Wilk, Ho-Chun Wei et autres

ABSTRACT Epithelial patterning in the developing Drosophila melanogaster eye requires the Neph1 homolog Roughest (Rst), an immunoglobulin family cell surface adhesion molecule expressed in interommatidial cells (IOCs). Here, using a novel temperature-sensitive (ts) allele, we show that the phosphoinositide phosphatase Sac1 is …

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A Tale of Two Protein Switches: Engineering, Characterizing, and Understanding a Novel and a Natural Switch

James V. Price

Genome-scale analysis of anti-metabolite directed strain engineering

Jeanne Bonomo, Michael Lynch, Tanya Warnecke, James V. Price et autres

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Diet Manipulation to Control Odor and Gas Emissions from Swine Production

Soenke Moehn, James V. Price, R. T. Zijlstra, William H. Sauer et autres

Functional genomic analysis of the 61D-61F region of the third chromosome ofDrosophila melanogaster

Ho-Chun Wei, Huidy Shu, James V. Price

Assigning functional significance to completed genome sequences is one of the next challenges in biological science. Conventional genetic tools such as deficiency chromosomes help assign essential complementation groups to their corresponding genes. We describe an F2 genetic screen to identify lethal mutations …

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The Sac1 Lipid Phosphatase Regulates Cell Shape Change and the JNK Cascade during Dorsal Closure in Drosophila

Ho-Chun Wei, Justina Sanny, Huidy Shu, David L. Baillie et autres

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Comparative modeling of the phosphatase and kinase domains of protein tyrosine phosphatase and insulin receptor kinase from Drosophila melanogaster (DPTP61fm), and a computational study of their mutual interactions

Sanchita Hati, Sudeep Bhattacharyya, James V. Price, Alan Tracey

The components and functions of the insulin receptor kinase signaling pathway have been conserved in a broad range of Metazoa ranging from mammals to insects and nematodes. There is a high degree of sequence homology and functional similarity between the human insulin …

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Dominant Enhancers of Egfr in Drosophila melanogaster: Genetic Links Between the Notch and Egfr Signaling Pathways

James V. Price, Edward Douglas Savenye, David Henry Lum, Ashton Breitkreutz

The Drosophila epidermal growth factor receptor (EGFR) is a key component of a complex signaling pathway that participates in multiple developmental processes. We have performed an F1 screen for mutations that cause dominant enhancement of wing vein phenotypes associated with mutations in …

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