Lesley Hordon

P077 The Yorkshire Bone Network- why every region needs a Bone Network!

Claire Vandevelde, Shabina Sultan, Lesley Hordon

Abstract Background/Aims The Yorkshire Bone Network (YBN) was formalised in 2019, from a founding group of Yorkshire clinicians with a special interest in osteoporosis, meeting every four months since 1994 to discuss new drugs as they were licensed, the research underpinning them, …

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Estimating overdiagnosis in giant cell arteritis diagnostic pathways using genetic data: genetic association study

Charikleia Chatzigeorgiou, Jennifer H. Barrett, Javier Martı́n, Ann W Morgan et autres

OBJECTIVES: GCA can be confirmed by temporal artery biopsy (TAB) but false negatives can occur. GCA may be overdiagnosed in TAB-negative cases, or if neither TAB nor imaging is done. We used HLA genetic association of TAB-positive GCA as an 'unbiased umpire' …

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A High-Throughput Amplicon Screen for Somatic UBA1 Variants in Cytopenic and Giant Cell Arteritis Cohorts

James A. Poulter, Andrew Gough, John D. Isaacs, Michael Green et autres

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Predictors, demographics and frequency of sustained remission and low disease activity in anti-tumour necrosis factor–treated rheumatoid arthritis patients

Philip Hamann, John D Pauling, Neil McHugh, Gavin Shaddick et autres

OBJECTIVES: To investigate the frequency and predictors of sustained 28-joint DAS (DAS28) remission and low disease activity (LDA) in patients receiving anti-TNF therapy and changes in responses over a 12 year period. METHODS: Data from the British Society for Rheumatology Biologics Registry …

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A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

F. David Carmona, Augusto Vaglio, Sarah Mackie, José Hernández‐Rodríguez et autres

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Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

Sarah Mackie, John Taylor, Lubna Haroon‐Rashid, Stephen G. Martin et autres

INTRODUCTION: Giant cell arteritis (GCA) is an autoimmune disease commonest in Northern Europe and Scandinavia. Previous studies report various associations with HLA-DRB1*04 and HLA-DRB1*01; HLA-DRB1 alleles show a gradient in population prevalence within Europe. Our aims were (1) to determine which amino …

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Mapping trabecular disconnection “hotspots” in aged human spine and hip

Jean E. Aaron, Patricia A. Shore, Mizuo Itoda, Rory Morrison et autres

Trabecular bone disconnection is an independent factor in age-related skeletal failure where real termini (ReTm; rare in youth) may cause weakness disproportionate to tissue loss, yet their structural contribution at vulnerable locations remains uncertain. ReTm (previously recorded at the iliac crest) were …

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A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

F. David Carmona, Sarah Mackie, Jose‐Ezequiel Martín, John Taylor et autres

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control subjects from six different countries of European ancestry, was genotyped by the Immunochip array. …

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Bone Mineral “Quality”: Differing Characteristics of Calcified Microsphere Populations at the Osteoporotic and Osteoarthritic Femoral Articulation Front

Kathryn M. Linton, Lesley Hordon, Jean E. Aaron

The mineral front consists of large populations of organically enshrouded calcified microspheres (filamentous clusters) about 1 micron in diameter and associated smaller numbers of variably dense nanospheres, 30 - 40 nm in diameter. The discrete objects persist and modulate in maturity, and …

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Basic Science * 208. Stem Cell Factor Expression is Increased in the Skin of Patients with Systemic Sclerosis and Promotes Proliferation and Migration of Fibroblasts in vitro

Sarah Karrar, Shiwen Xu, Joanne Nikotorowicz-Buniak, David Abraham et autres

Background: Previous research has suggested that the severity of RA has decreased over time. This study examines the pattern of disease severity in patients with inflammatory polyarthritis (IP) at time of registration into the Norfolk Arthritis Register (NOAR). Methods: NOAR is a …

Are admissions for gout preventable? An audit

Anetha Sabanathan, John Dillon, Lesley Hordon

The number of ward referrals due to gout has increased. Gout can result in a prolonged admission. Guidelines already exist for gout treatment [ 1 ].

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Diffuse pigmented villonodular synovitis in a child – what is the best management?

Sharmin Nizam, Lesley Hordon

A 5 year old boy presented to orthopaedics in 2004 with a 3-4 month history of intermittent left knee pain.As examination was normal he required no specific treatment.In 2007, he attended A&E with a spontaneous left knee effusion with a CRP of …

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