Estimating overdiagnosis in giant cell arteritis diagnostic pathways using genetic data: genetic association study
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Le résumé fourni par la source
OBJECTIVES: GCA can be confirmed by temporal artery biopsy (TAB) but false negatives can occur. GCA may be overdiagnosed in TAB-negative cases, or if neither TAB nor imaging is done. We used HLA genetic association of TAB-positive GCA as an 'unbiased umpire' test to estimate historic overdiagnosis of GCA. METHODS: Patients diagnosed with GCA between 1990 and 2014 were genotyped. During this era, vascular imaging alone was rarely used to diagnose GCA. HLA region variants were jointly imputed from genome-wide genotypic data of cases and controls. Per-allele frequencies across all HLA variants with P < 1.0 × 10-5 were compared with population control data to estimate overdiagnosis rates in cases without a positive TAB. RESULTS: Genetic data from 663 GCA patients were compared with data from 2619 population controls. TAB-negative GCA (n = 147) and GCA without TAB result (n = 160) had variant frequencies intermediate between TAB-positive GCA (n = 356) and population controls. For example, the allele frequency of HLA-DRB1*04 was 32% for TAB-positive GCA, 29% for GCA without TAB result, 27% for TAB-negative GCA and 20% in population controls. Making several strong assumptions, we estimated that around two-thirds of TAB-negative cases and one-third of cases without TAB result may have been overdiagnosed. From these data, TAB sensitivity is estimated as 88%. CONCLUSIONS: Conservatively assuming 95% specificity, TAB has a negative likelihood ratio of around 0.12. Our method for utilizing standard genotyping data as an 'unbiased umpire' might be used as a way of comparing the accuracy of different diagnostic pathways.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Estimating overdiagnosis in giant cell arteritis diagnostic pathways using genetic data: genetic association study
- Date Crossref
- 04/12/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Leeds pays non établi dans la noticeUniversité ou école supérieure
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Instituto de Parasitología y Biomedicina "López - Neyra" pays non établi dans la noticeStructure de recherche
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Leeds Teaching Hospitals NHS Trust NIHR Leeds Medicines and In Vitro Diagnostics Co-operative pays non établi dans la noticeÉtablissement de santé
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NIHR Leeds In Vitro Diagnostics Co-operative pays non établi dans la noticeStructure de recherche
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School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Institute of Parasitology and Biomedicine Lopez-Neyra pays non établi dans la noticeStructure de recherche
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NIHR Leeds Biomedical Research Centre pays non établi dans la noticeStructure de recherche
University of Leeds, Instituto de Parasitología y Biomedicina "López - Neyra" et NIHR Leeds Medicines and In Vitro Diagnostics Co-operative — Leeds Teaching Hospitals NHS Trust, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.