Hayley B. Schultz

Clinical Presentation of Tethered Cord and Outcomes of Tethered Cord Untethering Surgery in ZC4H2-Associated Rare Disorders (ZARD) (P2-6.020)

Sue K. Park, Sydney Peters, Ryan Carrier, Kristin Falbo et autres

To characterize the prevalence and clinical presentation of tethered cord (TC) and outcomes of surgical untethering in pediatric patients with ZC4H2-Associated Rare Disorders (ZARD).

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Pharmacokinetics and Bioavailability of Cannabinoids Administered via a Novel Orobuccal Nanoparticle Formulation (NanoCelle™) in Patients with Advanced Cancer

Stephanie E. Reuter, Hayley B. Schultz, Andrew J. McLachlan, Jeremy David Henson et autres

Introduction: The administration of cannabinoids for disease and symptom management such as pain continues to elicit significant interest, albeit limited information that is available regarding their pharmacokinetics and pharmacodynamics to guide clinical practice. Cannabis-based medicines contain a wide variety of chemical compounds, …

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ALLG APML5: bioavailability and safety of oral arsenic trioxide assessed during consolidation therapy for APL

Harry J. Iland, John Reynolds, Alan V. Boddy, Hayley B. Schultz et autres

ABSTRACT: The prognosis for patients with acute promyelocytic leukemia (APL) has improved dramatically since the introduction of all-trans retinoic acid and IV arsenic trioxide (ATO). However, ATO administration requires daily infusions over several months, representing an onerous burden for hospitals and patients. …

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Enhanced oral absorption and biodistribution to submandibular salivary glands of D-limonene in Sprague Dawley rats via a liquid-lipid formulation approach

Leah Wright, Anthony D. Wignall, Santhni Subramaniam, Hayley B. Schultz et autres

Decreased saliva production due to salivary gland damage can result in difficulty speaking and swallowing, significantly reducing quality of life for head and neck cancer patients receiving radiotherapy. It is therefore imperative that treatment options are available to mitigate the effects of …

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Enhancing the pharmacokinetics of abiraterone acetate through lipid-based formulations: addressing solubility and food effect challenges

Ali Taheri, Ruba Almasri, Anthony D. Wignall, Hayley B. Schultz et autres

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Effect of combined tobacco use and type 2 diabetes mellitus on prevalent fibrosis in patients with MASLD

Oluwafemi O. Balogun, Jeffrey Y. Wang, Emad Salman Shaikh, Karine Liu et autres

BACKGROUND: Several studies have investigated the independent effect of cigarette smoking or type 2 diabetes mellitus (T2DM) on MASLD. However, the interaction effect between tobacco consumption and T2DM on MASLD severity remains underexplored. In this study, we assessed the combined effect of …

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Sa1579 TOBACCO USE SYNERGISTICALLY INCREASED THE RISK OF HEPATIC FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS WITH TYPE 2 DIABETES MELLITUS

Oluwafemi Samson Balogun, Emad Salman Shaikh, K. Liu, Jeff Wang et autres

Analytical and Non-Analytical Variation May Lead to Inappropriate Antimicrobial Dosing in Neonates: An In Silico Study

Thi Anh Nguyen, Ranita Kirubakaran, Hayley B. Schultz, Sherilyn Wong et autres

BACKGROUND: Therapeutic drug monitoring (TDM) of aminoglycosides and vancomycin is used to prevent oto- and nephrotoxicity in neonates. Analytical and nonanalytical factors potentially influence dosing recommendations. This study aimed to determine the impact of analytical variation (imprecision and bias) and nonanalytical factors …

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The Influence of Blonanserin Supersaturation in Liquid and Silica Stabilised Self-Nanoemulsifying Drug Delivery Systems on In Vitro Solubilisation

Amalie Møller, Hayley B. Schultz, Tahlia R. Meola, Paul Joyce et autres

Reformulating poorly water-soluble drugs as supersaturated lipid-based formulations achieves higher drug loading and potentially improves solubilisation and bioavailability. However, for the weak base blonanserin, silica solidified supersaturated lipid-based formulations have demonstrated reduced in vitro solubilisation compared to their liquid-state counterparts. Therefore, this …

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Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development

Hayley B. Schultz, Adele Hosseini, Andrew J. McLachlan, Stephanie E. Reuter

Background and Objectives: Cannabidiol (CBD) is increasingly being studied as a therapeutic option for a range of health conditions; however, the pharmacokinetics of CBD is not well understood. This study characterized CBD pharmacokinetics in healthy adults using a population pharmacokinetic approach, informing …

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Bio-enabling strategies to mitigate the pharmaceutical food effect: A mini review

Tahlia R. Meola, Kristen E. Bremmell, Desmond B Williams, Hayley B. Schultz et autres

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Role of Silica Intrawall Microporosity on Abiraterone Acetate Solubilization and In Vivo Oral Absorption

Ruba Almasri, Hayley B. Schultz, Amalie Møller, Kristen E. Bremmell et autres

SBA-15 mesoporous silica (MPS) has been widely used in oral drug delivery; however, it has not been utilized for solidifying lipid-based formulations, and the impact of their characteristic intrawall microporosity remains largely unexplored. Here, we derive the impact of the MPS microporosity …

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